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Database: UniProt
Entry: A0A0K9YZ27_9BACL
LinkDB: A0A0K9YZ27_9BACL
Original site: A0A0K9YZ27_9BACL 
ID   A0A0K9YZ27_9BACL        Unreviewed;       426 AA.
AC   A0A0K9YZ27;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE            Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
DE            EC=1.1.1.88 {ECO:0000256|RuleBase:RU361219};
GN   ORFNames=ADS79_06040 {ECO:0000313|EMBL:KNB73505.1};
OS   Brevibacillus reuszeri.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX   NCBI_TaxID=54915 {ECO:0000313|EMBL:KNB73505.1, ECO:0000313|Proteomes:UP000036834};
RN   [1] {ECO:0000313|Proteomes:UP000036834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9887 {ECO:0000313|Proteomes:UP000036834};
RA   Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA   Shi H., Pan Z., Liu X.;
RT   "Genome sequencing project for genomic taxonomy and phylogenomics of
RT   Bacillus-like bacteria.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-
CC         methylglutaryl-CoA + 2 H(+) + 2 NADH; Xref=Rhea:RHEA:14833,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.88;
CC         Evidence={ECO:0000256|RuleBase:RU361219};
CC   -!- PATHWAY: Metabolic intermediate metabolism; (R)-mevalonate degradation;
CC       (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361219}.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC       {ECO:0000256|ARBA:ARBA00007661, ECO:0000256|RuleBase:RU361219}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KNB73505.1}.
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DR   EMBL; LGIQ01000005; KNB73505.1; -; Genomic_DNA.
DR   RefSeq; WP_049737507.1; NZ_LGIQ01000005.1.
DR   AlphaFoldDB; A0A0K9YZ27; -.
DR   STRING; 54915.ADS79_06040; -.
DR   PATRIC; fig|54915.3.peg.6627; -.
DR   OrthoDB; 9764892at2; -.
DR   UniPathway; UPA00257; UER00367.
DR   Proteomes; UP000036834; Unassembled WGS sequence.
DR   GO; GO:0140643; F:hydroxymethylglutaryl-CoA reductase (NADH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR   Gene3D; 1.10.8.660; -; 1.
DR   InterPro; IPR002202; HMG_CoA_Rdtase.
DR   InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR   InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR   InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR   InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR   InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR   NCBIfam; TIGR00532; HMG_CoA_R_NAD; 1.
DR   PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR   SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR   PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR   PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR   PROSITE; PS01192; HMG_COA_REDUCTASE_3; 1.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|RuleBase:RU361219};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU361219}.
SQ   SEQUENCE   426 AA;  45371 MW;  1D03EEACE2A8BC53 CRC64;
     MSTSRVSGFY KISPEERLNL IASSKQLSEE EKQILSGATP FPLKSANAMI ENAVGVMSIP
     LGIATNFKIN GVDRFVTMAT EEASVVAAAS NAARTAYELG GFFTSLSGSI MRGQIQVVGL
     PDPYGAMARI YENKQGILDR CNAKDPTLVS LGGGAIDVEV HVIERAKEPM LVVHLLVDTR
     DAMGANAVNT MAEAVAPYIE EVTSGQVVLR IISNLADRRL VRARAVFAAE ELGGAEVVRN
     IIRAYEFAEC DPYRATTHNK GIMNGISAVV LATGNDTRAV ESGAHAYASV SGRYRSLTRW
     EINQDGNLVG TIELPMAVGI VGGATKSHPT ARTALKVMDI QNAEELAGTI AAVGLAQNLA
     AMRALAAEGI QKGHMALHAR NLAVMAGAKD DQIDEVVKQA ILVKDVRYDR ILELTKQLQA
     GVANEN
//
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