ID A0A0L0AII3_9ENTR Unreviewed; 380 AA.
AC A0A0L0AII3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Multidrug transporter {ECO:0000313|EMBL:KNC07518.1};
GN ORFNames=AC791_17385 {ECO:0000313|EMBL:KNC07518.1};
OS Klebsiella sp. RIT-PI-d.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=1681196 {ECO:0000313|EMBL:KNC07518.1, ECO:0000313|Proteomes:UP000053401};
RN [1] {ECO:0000313|Proteomes:UP000053401}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIT-PI-d {ECO:0000313|Proteomes:UP000053401};
RA Tan N.E.H., Lee Y.P., Gan H.M., Savka M.A.;
RT "Whole genome sequencing of endophytes isolated from poison ivy
RT (Toxicodendron radicans).";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC07518.1}.
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DR EMBL; LGIT01000012; KNC07518.1; -; Genomic_DNA.
DR RefSeq; WP_049841741.1; NZ_LGIT01000012.1.
DR AlphaFoldDB; A0A0L0AII3; -.
DR STRING; 1681196.AC791_17385; -.
DR PATRIC; fig|1681196.3.peg.3788; -.
DR OrthoDB; 9800613at2; -.
DR Proteomes; UP000053401; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009636; P:response to toxic substance; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF21; MULTIDRUG EXPORT PROTEIN ACRE; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000053401};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..380
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005533935"
FT DOMAIN 62..287
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT DOMAIN 288..354
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
SQ SEQUENCE 380 AA; 40369 MW; D96B35DEF1463929 CRC64;
MTIHARTTLL SSLFISAALM AGCDDKGNQQ PTLPAPQVTV HVVKSAPLTV TTELPGRTSA
FRIAEVRPQV NGIILSRNFT EGSDVNAGQS LYQIDPATYQ AAWDSAKSDL AKSEAAASIA
HLTVKRYVPL LGTKYISQQD YDQAVANARQ ADATVLAAKA AVETARINLA YTKVTSPISG
RIGKSFVTEG ALVTNGQANA MATVQQLDPI YVDVTQSSND FMRLKQASLQ KGSAASSVQL
LMENGQPYAM KGSLQFSDVT VDENTGSIIL RAIFPNPRHQ LLPGMFVRAR IDEGIQPNAI
LVPQQGITRT PRGDATALVV NNESKVELRN VMASQAIGDK WLITDGLKNG DKVIISGLQK
AAPGATVKAV TDVTAATLAQ
//
