ID A0A0L0BLG1_LUCCU Unreviewed; 922 AA.
AC A0A0L0BLG1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Calcium-binding mitochondrial carrier protein Aralar1 {ECO:0000313|EMBL:KNC20798.1};
GN ORFNames=FF38_00106 {ECO:0000313|EMBL:KNC20798.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC20798.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC20798.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC20798.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC20798.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SUBUNIT: Homodimer (via N-terminus). {ECO:0000256|ARBA:ARBA00038674}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC20798.1}.
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DR EMBL; JRES01001702; KNC20798.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0BLG1; -.
DR STRING; 7375.A0A0L0BLG1; -.
DR EnsemblMetazoa; KNC20798; KNC20798; FF38_00106.
DR OMA; HYIWIST; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0043490; P:malate-aspartate shuttle; IEA:UniProt.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd22249; UDM1_RNF168_RNF169-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45678:SF9; CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1; 1.
DR PANTHER; PTHR45678; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 21..128
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 335..370
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 406..441
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 570..661
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 669..753
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 761..849
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT COILED 140..214
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 922 AA; 103985 MW; 0E24AE2CD910AEC0 CRC64;
MFNNFQPIVW IIKPVQCQDY TWFDALTKCA SMNMSLATID TKEKSDEITD LLSKTFGNVN
GMWIGAIANG KDHHYIWIST GNEITFSNWS PGEPNFQNAQ EYCVLTGWTD KIKWNDGGCY
SLQGVICDFN DYNYNLNELK EFYEAKLQEE MLKEQELQNQ LQNELAKEQE LKDQLQKELE
NKNQNQLENE QELQKQLKQE LEKEQKLQSQ LQKNQLLLQM LLDYRFYNDD RNNINVTNYL
KTKKDYQLQI IAGHSFLKRA STDKLREVFQ KYATYEKNGE HFMTSEDFVR KFLGLFTDAA
FNDESVRLLA GIADTSKDGL ISFSEFQAFE GLLCTPDALY KTAFQLFDRQ GNGTVSYSDF
ADVVQKTELH SKIPFSLDSP FIKRYFGEKK QRLINYAEFT QLLHDFHEEY AMEAFRSKDP
AGSGYISPLD FQDIMVKVKK HLLTADVKDN LVAVTEGHKV SFPYFMAFTS LLNNMELIKR
IYLHSTQGNR TEPVTKDELL YAAQTMSQIT PLEIDILFQL TGALHQTGRI VYSDLSNIAP
EHYTKHITTR LAEIKAVESP ADRSAFIQIL ESTYRFTLGS LAGAVGATVV YPIDLVKTRM
QNQRTGSYIG EVAYRNSWDC FKKVIRHEGV MGLYRGLLPQ LMGVAPEKAI KLTVNDLVRD
KCTDKQGQIP LWSEILAGGC AGASQVVFTN PLEIVKIRLQ VAGEIAGGSK VRALSVVRDL
GLFGLYKGAR ACLLRDVPFS AIYFPTYAHT KALFADEDGY NHPLTLLAAG AIAGVPAASL
VTPADVIKTR LQVVARSGQT TYSGVWDATK KIMAEEGPRA FWKGTAARVF RSSPQFGVTL
VTYELLQRLF YVDFGGSHPT GSEVNKLKAI DTSNVRINAD HIGGYRAAVP LLNGIESKFG
LFLPRFGHAQ PQSSATTAKT TS
//
