ID A0A0L0BPE1_LUCCU Unreviewed; 1793 AA.
AC A0A0L0BPE1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Transient receptor potential cation channel protein painless {ECO:0000313|EMBL:KNC21853.1};
GN ORFNames=FF38_03246 {ECO:0000313|EMBL:KNC21853.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC21853.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC21853.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC21853.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC21853.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC21853.1}.
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DR EMBL; JRES01001578; KNC21853.1; -; Genomic_DNA.
DR EnsemblMetazoa; KNC21853; KNC21853; FF38_03246.
DR OMA; GANPREW; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR47143; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR PANTHER; PTHR47143:SF3; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF00520; Ion_trans; 2.
DR SMART; SM00248; ANK; 12.
DR SUPFAM; SSF48403; Ankyrin repeat; 4.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KNC21853.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 496..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1383..1406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1418..1439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1445..1465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1477..1499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1519..1537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1584..1605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 368..400
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 499..748
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REPEAT 1259..1291
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1387..1616
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1793 AA; 206093 MW; CE367E3AA20DB554 CRC64;
MSNKYSTIDI SGCLADPQTQ LSRALANRDI RDFRVALDMG AEPTVPDDKH ICVFEKALQT
HGCSEFVEEC LKRDCNVNYI NQHFNKAAIN YAADSKDPKI LNAILRYPGV AVDRKYANMT
PLNSLAKNLN SENANDVASC LQMLLHYGAS PNIPDQREMT PLHQVVKNRK LDDLKKREII
QMFLQQPDLD IDTYRDGELR TILKTDYAEF SLPAMRDGKT VDFDILMTHI RNGDMEKFQQ
QFPEYQLNIS DKDNLKNTTK EENLPLLIEA IKRGAHEAFD LLMKNEVDYN AVLNGNTPLE
VATVCGNWYA LQKLLQQNDL KIRREDQPLI TAIRKLNELP VNDFCDYRRC FYTLLDSEKI
DVNEMDKSKS TPLHYAVKYR NNEAIRELLK RGAYIGIKSE FNELPIDGMN PEILEEHFDN
CITSNGVKVG DNSYEILINY MNLMPQNSSV QKKSAHQLRE EMPPIAFLAK SRDHRHLLQH
PLITSFLFLK WHRLSVIFYI NFMLYLFFAV SIITHTMLKF RESEHEYVAA LFGIFSWIGI
CYMILRECLQ FIMSPVNYFR SLINYMEIVL IILSIMTCSE PSYDKETQRN IAVCTFLLIA
VELCFLVGSL PVSSISTHML MLDAVFRSFL KSFLLYSIFV ITFTLCFYIM FGKPEINAVK
EEATPSSTKD GNNDDDGDDG EFSQFKSPLG ALAKTIVMLT GEFDAGDLKF DTFCSYLLFL
LFVFTMTIVL FNLLNGLAVS DTQAIKGQAE LNGIIVRTNL LSRYEEVLTG RSERANFIVN
HEPFRTICRR IMNLYPNYIA GKQIAILPND NNKVLIPLTN TFEMKEMSVH KDSFMPLANH
DSEKLNKILD PPVKFLPCCC SFITSKCSEM DRRTVKMAMA VIDKKSLSIQ EQIRVQSTEK
RLHSIEQKLE KMFEIKLSKS LINRDLIEFR AALSIGANAL AKDEQNLSIF EKALQTPGCS
EFIKECLSSG CDPNYINSFY NKAAVNFATD SRDPDNLKEL LIAPGVKVDH KYSNLTPLNS
LAKNLNNENS QKVIECIKIL LHYGASPNIP DQREMTPLHN IIRNHKINDV QKYELIQMFI
SLADIDIDTY REGELREILE REYPLMELPV KKDQNVVTFR SLLSHIRNAN MDVFEQQYAD
NSRHTSQDEE VELLVAAIET GAHRAFDLIL ANGVDYNKSI RNNNNSNTPI EIAWVYGNWY
ALEKLLQLPD IKLRAQDNPL INIVCKLNET SSQAFCNYWK CFTVLLESDK IDINASDFSK
STALHYAVKY HNNKAIKELL KRGACISVEN KFQELPLNGM SPSVWEEHLD DCVFSNGDKL
GDKSYEIIIN FQNFMNTQQK KKKQLKEVLA PISFMAETKE YRYLLQHPVI TSILFLKWHK
LSLVFYINFL AYLFFALSIV THMILKLRNI DKENAEKITL YCSYLGISYL ITRECLQVIM
APWKYIRSIT NYLEILLIIL SLLTCKDLKS DDLQRNIAVA CILLLAYELF LLVGSLPISS
ISTHMLMLEA VCKSFVKSFL FYSIFVFTFT LCFYIKIGNE KIEDPEEKFH SFSEPLLAFS
KTIVMFTGEF DAGSLKLDTD YTRLLFLSFV FFMTIILFNL LNGLAVSDTQ AIKDQAEIND
IICRTHLLSR YEKAVYKKNL NFSFILKREP IRSICRIFSK LFPDYTTDVQ ISILPNDKNK
IYGLKLQNKV SNTMNVSETT TIIKRTAISI DGEEEDDNNS DIFTKNKYIS CCFSGFTDRC
SRIDERTVNQ AMAILEKKSN VTIENRLDTM EEQLKEIIKF LKMQNSEVGE ECI
//
