ID A0A0L0BQ40_LUCCU Unreviewed; 5043 AA.
AC A0A0L0BQ40;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RIIa domain-containing protein {ECO:0000259|SMART:SM00394};
GN ORFNames=FF38_01851 {ECO:0000313|EMBL:KNC22177.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC22177.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC22177.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC22177.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC22177.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC22177.1}.
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DR EMBL; JRES01001539; KNC22177.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0BQ40; -.
DR EnsemblMetazoa; KNC22177; KNC22177; FF38_01851.
DR OMA; KHTTSMD; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR CDD; cd12084; DD_RII_PKA-like; 2.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 2.
DR InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR Pfam; PF02197; RIIa; 2.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00394; RIIa; 2.
DR SUPFAM; SSF47391; Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit; 2.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 11..49
FT /note="RIIa"
FT /evidence="ECO:0000259|SMART:SM00394"
FT DOMAIN 86..123
FT /note="RIIa"
FT /evidence="ECO:0000259|SMART:SM00394"
FT REGION 284..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1894..1929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2253..2284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2381..2422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2438..2469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2569..2593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2606..2626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3014..3045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3122..3165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3188..3336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3362..3394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3464..3486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3666..3686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3841..3871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4918..4964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1897..1926
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2265..2284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2381..2402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2403..2422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2441..2468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3023..3045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3188..3249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3264..3295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3296..3329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3362..3384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3670..3686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3841..3867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4922..4940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4950..4964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5043 AA; 573002 MW; FF81119A19B897A7 CRC64;
MSTITKPRVP DGLRELMKDL TREILKEKPT DIYDFAENYF QSRLPEKENY AVKSFEECSG
KYDFSYIQNP QRYQIPVALV YSIIPEGLTN LIKDLIKAIL REQPSNLCDF AVEYFRHIKA
ATCKESLDGT KEINYSAYEK YFMNKERFLF TPYVKCTCGR TLGEAYSNNS QIENLIAIHK
IQNYNTTLLS KSLVADDSNN NNSVNKITEN DTISYEKYMN SIYIIQRCLR RYLKEKRGTT
NTNQVSPNHN TFDHHSVTAE PMITKQYKQT SLIPSVPQLQ LNQNESENIS EDASYTSAST
AVLSASESGR ETSEPSMYEN IVTKTIMEDV EMENDEKNIS SQSTRDHVKY DTSTNNNEEK
STNNVNDGEG TRDINAAKLL DTQNAEFDSM EIDTMKNRNE SGEINEQPVD DIDIKDFGKL
QKTSVDILDA NFESHNKDLK KEKSFSGHKI SAENKITEVG GKSKLTKDAN ESTEAGDKKF
RKKMDQTDLI DSTGNNNLET VEKYQILEKV KISKEEQSQN LDKPKDNINV KSKLLEEISQ
NEIDKVPIRN PSDVFNDYNS HATTESNTND EEKLKEIKNE TVSDKAEFLE NIKESNKADK
IEEKLSIDSD NNVKKDDADD SVTKNFADFK ESTNITDEIT TQLNTNDSAN LKHEIDIILG
GTKKGDLENN IKVTEIISDK DNSYSHIIED NEMDLKHDKQ FDDAIKLNEI DNKSVLIQQK
NNDEGKTTES TKNYDEIELK NEKVEKDGTT KTHKIDEITT DSEFDKTINN KDKSGDADSN
NHETSRATAE YELNKNSELS NQTSSQEKNN TDTNIAVREK SPNTSSHTNE TDKNLIEKFE
IISDIDNSYS NIILNNEMDL KLDKKFNEAM ELNELDNKSV LIQQKIDDEN EEGGTIITSK
IDEITIESKF DKSVNKNNKS GDSGLNNQET LRATAEYELN KKSELNDQTS PQETNNTDTN
ITLREKSPTK LSDLNEIDMN FVEKSVIISD KDNSSSHIML NLKHDNKSND TMEQNKKSVL
IQPQNNGDGK TFPSTKDDEI KLDNEELEID GKTIINKTDV NNENKSGDVA SYNQQTTRGS
AENEFNINLD LTDQNSLQKE NNSDTHIAVR EMSAMKFRDT NETDKNLIEK SNKNLSDMLE
KEIDLTHGNK FEIKYDINKN LNKSSEQMEK KLIDGNKFDV EPQENNIEES ERNELVNSTN
KNISVDTDEK VRSENDDMVI YRRENTQHKF KLQDSSTQNL MNYDKNFKTN SQKSIIDELK
ATTTKNELDT DVNEYKFDEE FIQTESKTKS VSNELNEKLE NYKSFKKAVT SDLDKSDKHK
VNNTIESSIQ ANNNGNVATN VQESTPVDLN EKTNESLKMN IEKESDNNVN KEIDNSEYDK
NLEGSIKMDL DNNATSIYEN ISLTSEQLSQ KQQSKFNTET NAAIEPTNQK EIKIIQTENI
QTVVEYSRKD NDIKTTDDQE PIHIDLNEKG NESLNSLPVL DTEHDHGGRY LKDNKNTTSV
DKNIKLSSEY LTQKRQSESN LKNNSIEPKK FQKENIQTEV GSHRNDNDFK GEECVTKTVQ
GPTRVDLNEN TNESLNNEGV KNLKGSIKIV LDNNTTSMDE KINLTSENVT QEQQSESNLI
NTVCKPTNQN EIMLIQTEEY LTTDDQIDIH TTSMDKSMNL TSKNLTQKRQ SESNLTNTAI
EPKIIRNENI PTDVESSRND KDIKTEEYVT RDDQEDKHTT SMDENINLTS ENLTPKHQSE
SNLANTATEL KIIPNENIQT DVEFSRNDKD IKTEEYVTRD DQGDKHTTPM DESIYLTSEN
LTRKHQSEST LANTATKLKI IPNENIQTDV EFSRNDKDIK TEEYVTRDGQ GDKHTTSMDE
NINLTSENLT PKHQSESNLT NTATEPKIIP NENIKTDVES SRNDKDIKTE EYVTRDDQED
KHTTSMDENI NLTSENLTPK HQSESKLTNT ATELKIIPNE NIQTDVEFSR NDKDIKTEEY
VTRDNPEDKH TTSMDENINL TSENLAQKHQ SESNLTNTAT EPKIIQNENI QKDVESSRND
KDIKTEEYVT RDDQEDKHTT SMDENINLTS ENLTPKHQSE YHLTNTATDR IIIQNENIQT
DVEYTRNYKD FKTEEYVTRD DQGDKHTTSM DESINLTSKN LTPKHQSESN LTNTATEPNI
IQNENIQMDV EYSKKNKDIK TEEYVTRDNP EDKHTTSMDE NINLTSENLT QKHQSESNLT
NIATELKIIP NENIQTNFES SRNDKDIKTE EYVTRDDQGD KHTTPMDESI NLTSGNLTPK
HQSESNLTNT ATELKIIPNE NIQTDVESSR NDKDIKTEEY VTRGDQGDKH TTSMDESINL
TSENLTQKHQ YESNLTDTAT EPNIIQNENI QMDVESIRND KDIKTEEYVT RDDQEDKHTT
SMDENINLTS ENLTPKHQSE SNLTNTATEL KLIRNENIQT DVESSRSDKD IKSEEYVTRD
DQEGKHTTSM DESINLTSET LSQKCQSNFT NTASEPKIIK KESIQIEVES RRNNTDVTTE
EAQAQNLHNI NQLKASQSET NYSENIDDLA IQNADYNLDE KLYETENEIA TSGTSNVPKE
ISPSKLENKK DNKFESDLQI TNTLNKTENS TPINNSNLLN EPSQPISDES CNETCVEIIN
KKSETGDFVS TTNANKQNNI SSEMTKIDSF DANSINISNN NDETTNNEDY PIHDSNMTDE
LIDKTFTLKS SRAINVEHVN KNIVETLQTD SENSKTNVNV DDTISDTNIT DEIITKNCVK
ESQVEKHTEG KEITYRDDIT SSKISSKQLE VSSEKSTNIL KKAIKDAMES SENENLIKGE
TVIRETNEQG DHITSENQVF LSTSKNSQNK YLYESHDHQT EDQTEHIMEK RDVKQLEIGP
DASTKEDYDT KAIPLSVENE RNQSSELQSG ISKHEKSAVN KIDSDNFDQK EKHVDERCNY
EELANKINSG EDQELSVKNK TKPLEKLLED LDVANSDSIK ANDDNIETTN SDTAGIITNV
GINDKIMELK NDFKKSSSHK IVKQETQIKQ IQESQENESE NESNYSSLVQ VDNQNLKDLN
DINEDNRDNQ KEVSKQNIVI NMDDSNSKLI VEKSINKEND VQKAISNNEN IHGDKEISKI
SLKSKEIETH DDKDFNSQSR NKREAENYPN SEHKHNNELG DTKKDITVHD DDVLGLRDKN
VIGDNVHLNE DNNSLGSNMN KLQSSVSDTQ VSSLDVQQQQ PTHEKNYTSK NETNAKNLAS
PSFPIQKKST ETNKLKDNQP NEIKKENFNS STVQNTEKTE TTINESSNIE QNISRTSKDE
TLDCTSKYDS KDKLLEIDDT QEHKNESNNK NVAKTSNINS SIDQTYHCNQ QVSNINQNES
VHHYKSDREG TQADADDKKP QMSSQDNIKQ ENTEQRLTDV TAETTNDEVY FETFIGNQNL
TIGRIRNFNE GLLGSISGQR FAETHLRSFW KEYVMNNSMP LSQYDYKENE PKKPPETGTS
QQQNVNQVNE TNLSAYKNEE KPIDIIEPEI IKETIKHSES SPVMNHNIST ANNDSTPSKD
IERIPRYFYG VPDTEPNYSS SCSKRKSYKE PTAFTIAIGD LNKKQNTKIA KSPKSNKDVE
CLKSDIKLNL NKLDLSEKEY AEPLLESETP PKVFQDLNEF EYEIHDIDLD ITYTIDEIIR
LKIENDSQNN SDDNDTNGTS EYSLTPEPML QTIVELSESE TPKPPDQLHS IDDDFLANLE
RISDTTSTSW TTGSKEDNSF ISDEFLDEKN QNEYIKQGHT TSDSEHKTQG GIYEFSKDNM
AGKELKSQDY EEIIAQAPTP PNDDPFYGDL KETAAKTIQE AYRQFKQKKL LKPVENISKL
KAETESSNKR SNREMLNNKK DEHLTSKGNS TKFNVEKSSN LIYPKENNVK ATNSEQEFKI
PVNLTSHDGI NNFEYKKLEK YVINETILNP TDSESYNKNN IKKIFKNTEN YEDFKTMSEI
DYSNTKSSGN NFNFESKQAS IGQEIKTEEE HNVTIKFSVE KLKEEICNEV ATSTVRESSN
NIKFTNFNKD DKNNANTSIE GLNSEVFASH LNTESSNNTK DTNIDITTTD LKFDEYDKSQ
NLGRNEISTE NLESPNSNNI RDSYKETAIN EYDINDVNSN ELANQAMKID QKSSVNEHIK
EFSSKNTNIE SSNNIKDTNI NVTNTDPTIS ENNESQNHGG NEYVEIINVT STENFKGTPY
IEMASSTKNI IVANQPIETN IESLADKLKE KFNTEMASSI VLKETSNIIK DGNIDISNKD
FKFGLNEKSD INSNDFTNQT NDKTIHDDLP SDHIYFKPTA PAEEDIHSIV SIDSLQSNEI
LHDQAARKIQ KAFKNFIERK FKLSSNLGTF KESLKSNWFV GNEPIIAKKS LPKTKSEISF
EETEAYVELT TNPPQYLVDS SNNLEAIDAN NFSRSPTAPV TNRSRNSVDL ANYHSTNISK
DTVSVIGIDA GAIENANTEH SQVNTNNSTN MIPSKDKIGE NQAIKYPTLI DQFLNSERHY
SEAVNHHNKE IIFTSPDFTE IIKILSNSAG SQKQQHDSVI QYERLEEPCI KKSTSITHII
GDDAKNAEII SDTAINTDNS SSSDIDDTED SLSTKTVKLH KPDEAITKMQ QRRDSTTKIL
NLDKPKDYNF DEPLVVPIDN LDTDEEGIVV NKLQREETRE SSAQSDFDVI IGGNKDENFT
FLDSIDIEES FPSKGSLKRV HTIAGDGDSK SLLKNVTIDE SIKYIEPPDY ELNSGSLCLD
NDTAENIRRK MMAYSFSEAD SDCFDKSPST NDGTNSESKS QKYDDFNVST ALVENIDSST
ETESTIVSAV TKIQAGARGY LTRKRLGKAS MASDGKSMPH DDMNKASFGN AAISESLEYL
VQEAAAKRIQ RVYRQHYRKK LAEVNQKEDH SFSPEFTTSL ESTLAQKRSI MLQRGDALRN
DSTPDEGNSS SNGSGSENAK IEDISKNKNL SGNDESNNFD MQHLKKNTSG NYSLKATSTV
KTAATIRAKK IEENKIRWLA MRQNSMPVQI DSEVLRVIPK YMRKKIKSAD GGKKKDRRQV
LMD
//
