ID A0A0L0BVQ3_LUCCU Unreviewed; 1643 AA.
AC A0A0L0BVQ3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN ORFNames=FF38_02076 {ECO:0000313|EMBL:KNC23319.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC23319.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC23319.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC23319.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC23319.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC23319.1}.
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DR EMBL; JRES01001368; KNC23319.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0BVQ3; -.
DR EnsemblMetazoa; KNC23319; KNC23319; FF38_02076.
DR EnsemblMetazoa; XM_046945919.1; XP_046801875.1; LOC111685688.
DR OMA; TDEIFIA; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08368; LIM; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR15711:SF25; RADISH, ISOFORM I; 1.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 835..1053
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 63..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1555..1579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1602..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1643 AA; 185330 MW; E7C557E8F808DDF4 CRC64;
MPKLRQYMSM DQPSSTAIRK KTMTAVCFVC NLPIMSHQVG LVWSGGNGWD DLVREQLEES
TIRQRLGGRR DSAAQINTPP STSPPPGMQR RRRSSLAQLT DLLREWSGGV KHQSSQSQRA
TKAPLNRRET LADLARSLPW RTSVSDAATS AGPTYVAPRK RRESSADAGF RSTRTRRDSN
TAEFVKHWNR RESTVDEPTI VAVNVVVEPS KGGSRRDSGE SNHSSRRDSS IGRIITPSTT
PPPPPRIGVS PVKRDSLAAP EFPNFRYEQR PSTSSAGSDS MPLYSCSSHN QVDSSCQALP
PPTIIMSSVT PPATSPTAPK GRRDSTTQCG RVNRRDSKAG ISPERAPRLQ RLQRQATAFD
ESCLPGGSRR GSQPALSPDP PEEGQRRNSR RDSLSPDSAS RGGRRDSRTH LSPDRSHERE
GSPHRRHALR RQSSSAARSS RSPDSTSICS SRDASPCGRP PPLPVVEQGS SRPAIRRQST
TEEILIARGF RRQSTTEEMI RCRNFRRQSS QSDDVCRYRG RRDSSAQIID GTIGTMTVET
TSTFFDSSTQ TEPSPLYDNN HYHEECLRCN SCGLNLTGRN QKRARRFKNQ ILCDLHFADV
ALMECSDFMQ QLRSFKPQSL GCAVARRKSS TTLIFPLPPQ ACSDEFCEEY PHNLMPTPGY
WIECSRQKIT LPPTHTIWDE SDSEHEDIRG GNSSDAYLER ECSDLYEDDE DSEATPRKKT
TIEEQWEQNG AFELISVEQE TYEKYFFGCE HWNYFTSDED LGPVILSIKQ ETLNGRDQFR
ILVRAGSYTV HGLIPASCVF ADRYNREEVV RSLGKEVNLN PPLTLGQLPD TPEELLKLDQ
VFIKSELKVG VIYVKEDQYT EEQILDNNEN SLLFDEFLTL LGDRVRLKGF DKYKGGLDTV
HDLTGLYSVY TNWRNIEIMF HVSTLLPYER HDPQKLQRKR HIGNDIVCVV FLEADNTRFS
PACIKSHFLH TFILVRVSAR IKHKPTRYEV SVVTRDEVGA YKPYLWEQSV FEKGPMFREW
LLTKIVNGER ASYSAPKFAR MQERTRSQML EDLVMNLSNH AETGQIPKPY RRGSWRPIGE
EEYRKMLHAR VLANNAPITP LSSSMDVDVC CVLLCVKHSH MRPSSPLLDS VRDQFEDYDQ
LAKDFTRVFL NVEPSCLTNA HLFDVTFLVG QSKQKARFIG VRAILGVRSR VFQEMLYGIQ
TGFGSPQIPV AEIFARPAPS LVSPQNQKPK SNNYLTVPDS DSIRPKSVPS SPMVKRAFSR
LGTITAGWGR SIRNKNANQL NPEDKKKWIS STDCSNRDSK EKDKDKSGNN LAVPRLSVCA
DAQKVDRAKL AQTEFNIIEF DPDTFRVLLD YLHTGTCPLT CVSIPGLLCA AEHYDLPELL
QACFHHCKQF LRIEVVCPML ISLENYYWRY TSASELVNMI LSFVENKAHG LFKCPEFLNL
SESMVQMIMC RELQCPEIRK FEAMLAWARN KVSKMKIQPN RDTQFEFECI MDRLTRDLEL
CRISPTELLS IVLPSKALKN ERIMETLMMQ VNLGTYRMQE LDEYRQQLRS QESAEATNVS
FDIDRGGGSG ASGGDVSNAY DSTADDEVEF YNDFDATPTT SRVAAQMQAA KEARRRRWAG
DGSSAGSSEC GGGGVGSGAV KKH
//
