ID A0A0L0BZS3_LUCCU Unreviewed; 906 AA.
AC A0A0L0BZS3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Hemicentin-2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=FF38_05170 {ECO:0000313|EMBL:KNC25486.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC25486.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC25486.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC25486.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC25486.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC25486.1}.
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DR EMBL; JRES01001109; KNC25486.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0BZS3; -.
DR STRING; 7375.A0A0L0BZS3; -.
DR EnsemblMetazoa; KNC25486; KNC25486; FF38_05170.
DR OMA; QEFDCQV; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF162; LIMBIC SYSTEM-ASSOCIATED MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 750..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..84
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 90..159
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 185..272
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 279..389
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 392..489
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 496..610
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 782..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 100001 MW; 1B8859FFE74616E4 CRC64;
MVSDYPRVEV GPQNPLRVER DHVAKLDCRV DAKPMVSNVR WTRNGQYVST TPTYTIYRVN
HNHAGKYTCT ADNGLGKTGE KDLVLEVLYP PIVIIETKTH EAEEGETVLV RCNVTANPPP
ITIEWLKEGA SDFRFMGELL TLVSVRAEHA GNYICRAVNL MQPFGTKRVE GVGNSTVALL
VRHRPGQAYI TPNKPVVHVG NGVTLSCSAS PPGWPVPQYR WFRDMDGEFS NTQKILAQGP
QYSIPKAHLG SEGKYHCHAV NELGIGKMAT ITLEVHQPPQ FLAKLQQHMT RRVGDVDYAV
TCSAKAKPAP IIRWIKDGTE ILPGRKMFDI RTTPTETANG VVTVQSILKF RGKGRPNGNQ
LVPADRGLYT CLYENEVNSA NSSMHLRIEH EPIVLHQYNK VAYDVRESAE VICKVQAYPK
PEFQWQLGNN PSPLTMSSDG HYEISTRVDN NDIYTSILRI NHLSHSDYGD YACRAVNPLD
AIRTQIRLQP KGPPERPTNL KVLETAHNFV ILSWIPGFNG GMLSTKFLVT YRRVPTPREQ
LLSDCGAVHT FASSSGMSSP EWLEFDCFRD NPCKVAPLDQ HQSYMFKIYA LNAKGSSGYS
NEVLATTKVS KIPPPLHVTY DPNSHIVGIN VAATCLSLIA IVESLVNRAS PMATWEIVDT
VTLLPSGNEA TFKETTINHI TQRTHYSMTG GRSMSHAEDI TLALAENKQG PSVRVKLCLR
SNHDHCGEYT NAEIGKSYLP ETSSLTTSTI VAIVIATVAF LLFAAFSIML CRCRRSTTSA
KKSATNTAKE YDLDSGRPSI VAQTSGQQPP PPPYYPTGSL DSKTLDAHAM ELTHTAIQDS
DDQLLHQQQQ LQQQQTQCSN QKSSANSLYG TQNGYGYHMT SAIGVEGDSY QVIPSSGLHT
LAGGTE
//
