ID A0A0L0C063_LUCCU Unreviewed; 1143 AA.
AC A0A0L0C063;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA damage-binding protein 1 {ECO:0000256|ARBA:ARBA00014577, ECO:0000256|RuleBase:RU368023};
DE AltName: Full=Damage-specific DNA-binding protein 1 {ECO:0000256|ARBA:ARBA00031668, ECO:0000256|RuleBase:RU368023};
GN ORFNames=FF38_07869 {ECO:0000313|EMBL:KNC24849.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC24849.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC24849.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC24849.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC24849.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- FUNCTION: Plays a role in DNA repair. May be a component of an E3
CC ubiquitin-protein ligase which promotes histone ubiquitination in
CC response to UV irradiation. Histone ubiquitination may be important for
CC subsequent DNA repair. {ECO:0000256|RuleBase:RU368023}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|RuleBase:RU368023}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368023}.
CC Nucleus {ECO:0000256|RuleBase:RU368023}.
CC -!- SIMILARITY: Belongs to the DDB1 family. {ECO:0000256|ARBA:ARBA00007453,
CC ECO:0000256|RuleBase:RU368023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC24849.1}.
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DR EMBL; JRES01001168; KNC24849.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0C063; -.
DR STRING; 7375.A0A0L0C063; -.
DR EnsemblMetazoa; KNC24849; KNC24849; FF38_07869.
DR OMA; HQDFLMR; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.910; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR10644:SF3; DNA DAMAGE-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR10644; DNA REPAIR/RNA PROCESSING CPSF FAMILY; 1.
DR Pfam; PF03178; CPSF_A; 1.
DR Pfam; PF10433; MMS1_N; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU368023};
KW Nucleus {ECO:0000256|RuleBase:RU368023};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 76..545
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10433"
FT DOMAIN 793..1103
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03178"
SQ SEQUENCE 1143 AA; 127163 MW; 74DCC7BE1784AECF CRC64;
MSQYHYVVTA QKPTAVVACV TGNFTSPTDL NLIIARNSQL EIDLVTPEGL RPLKEVNIYG
QITVMKHFRP QDSKKDLLFI LTHRYNVMIL ECCMIGDQIK VITKAHGNVS HQYSPPTDGG
VMAVIDPKAR VIGMCLYMGL FTIIPLDKET SELRATNLRM DELNVYDVEF LYGCINPTII
VIHKDNDGRH VKTHEINLRD KEFMKIAWKQ DNVETEATML IPVPTPLGGA IVIGRESIVY
HDGNSYHAVA PSTFKQSTIN CYARVDSKGQ RYLLGNMYGQ LFMLFLETAD NGKGCASVRE
IKVELLGEIS TPECITYLDN GFLFIGSKHG DSQLVRLSTT PNESGSYVIP MENFTNLAPI
LDLAVVDLDR QGQGQIITCS GTFQDGSLRI IRIGIGIQEH ACIDLPGIKG MWSLKVGIDD
SSYENTLVLA FVGHTRILTL TGEEVEETDI PGFLSDQQTF HCANVDYDQI IQVTPLTVRL
IKSTTKNLVY EWQPSAGKRI GVVSCNAQQI VIASARDVFY LEIENEKLVQ VSQKTLEYEV
ACLDITPLGD GKNRSDLVAV GLWTDISAVV LTLPNLDVCH TEKLGGEIIP RSILMTTFEG
INYLLCALGD GSMFYFILNK DNGNLTDKKR VTLGTQPTTL RTFKSFATTN VFACSDRPTV
IYSSNHKLVF SNVNLKEVNH MCSLNAQAYP DSLALATKNS VIIGTIDEIQ KLHIRTVPLG
EGPRRIAYQE SSQTFAVATM RIDVQGRGGP KPTRASASTQ AQNITYASNI VPKPGACNTA
TTNAEIGQEL DISNLLIIDQ NTFEVLHAHQ FMPSESIMSI MSAQLGDDPN SYYVVSTALL
YADEPEPTVG RIIIFHYHDG KLTQVAETKI DGGCYSMVEF NGKVLAGINS FVRLYEWTNE
KELRMECNIQ KNITVLCLKA KGDFILIGDL MRSMTLLQHK QMEGIFIDIA RDSDPKFMRA
IEILDDDTFL GSEDNGNLFV CQKDSAATTD ELRSELPEVA RFHLGDYVNV FRHDSLVMQN
VGERTTPNQG CVLYGTVMGA IGIVTQIPQD FYDFLHSLEE RLTNVIKSVG KVDHSYYRSY
QTSQKTEPCE GFIDGDLIES FLDLTREKMK ECVTGLEITM NGEKKDADVD DVIKIVEDLT
RMH
//
