ID A0A0L0C1T7_LUCCU Unreviewed; 897 AA.
AC A0A0L0C1T7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Peptidoglycan-recognition protein LE {ECO:0000313|EMBL:KNC26217.1};
GN ORFNames=FF38_05391 {ECO:0000313|EMBL:KNC26217.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC26217.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC26217.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC26217.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC26217.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
CC {ECO:0000256|ARBA:ARBA00007553}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC26217.1}.
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DR EMBL; JRES01001003; KNC26217.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0C1T7; -.
DR STRING; 7375.A0A0L0C1T7; -.
DR EnsemblMetazoa; KNC26217; KNC26217; FF38_05391.
DR OMA; IACAKEQ; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd06583; PGRP; 3.
DR Gene3D; 3.40.80.10; Peptidoglycan recognition protein-like; 3.
DR InterPro; IPR036505; Amidase/PGRP_sf.
DR InterPro; IPR002502; Amidase_domain.
DR InterPro; IPR015510; PGRP.
DR InterPro; IPR006619; PGRP_domain_met/bac.
DR PANTHER; PTHR11022; PEPTIDOGLYCAN RECOGNITION PROTEIN; 1.
DR PANTHER; PTHR11022:SF78; PEPTIDOGLYCAN-RECOGNITION PROTEIN LE; 1.
DR Pfam; PF01510; Amidase_2; 3.
DR SMART; SM00644; Ami_2; 3.
DR SMART; SM00701; PGRP; 3.
DR SUPFAM; SSF55846; N-acetylmuramoyl-L-alanine amidase-like; 3.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 127..270
FT /note="Peptidoglycan recognition protein family"
FT /evidence="ECO:0000259|SMART:SM00701"
FT DOMAIN 139..276
FT /note="N-acetylmuramoyl-L-alanine amidase"
FT /evidence="ECO:0000259|SMART:SM00644"
FT DOMAIN 418..561
FT /note="Peptidoglycan recognition protein family"
FT /evidence="ECO:0000259|SMART:SM00701"
FT DOMAIN 430..567
FT /note="N-acetylmuramoyl-L-alanine amidase"
FT /evidence="ECO:0000259|SMART:SM00644"
FT DOMAIN 731..874
FT /note="Peptidoglycan recognition protein family"
FT /evidence="ECO:0000259|SMART:SM00701"
FT DOMAIN 743..881
FT /note="N-acetylmuramoyl-L-alanine amidase"
FT /evidence="ECO:0000259|SMART:SM00644"
FT REGION 22..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 100412 MW; 68EEC260174BFB66 CRC64;
MKEIVKKMLS LKVSNTSNVE TSDKEKQISK RISTTTGNTS PATKGQLVPD MNAIQDTLLE
LSTSVVKSNI TITDSSNVHL GNKINYDGNL YLNLLKQNNE TGISLIQHDN NNGVLIKTTS
NVHISDYPII PRSFWSIRKP REEYDKIKEP VGLVVISHTA TTSSTNQSKN IQLIRDIQAF
HVDTHNWNDI GYNFLIGCDG TIYEGRGWGI EGAHTFGYNN RSMGITFIGC FINKKPTEDA
LYACKNLLER GISEGHLDKN YKLLGHRQCS ETESPACETL DDAESLASSI VESSIVDSAS
EADGENSQDD DDDSRSYTNI SELPIYNQLL NTNSLRKQLE QIAPLATYNN VNVANSSNVV
FGNVIKVKGV LNINVYNKDK NNKNYNENQE ENIDPLHKRR ESSPQANKES LNDNSSLCRI
IPRNYWSTLE PSEEFEYVDG PVDIVIISHT ATDSSLSSQE NTQLLRNIQT FHVDVQGWDD
IGYNFLIGCD GNIYEGRGWN VVGVHTYGYN RRSLGIGFIG SFSRSLPSEK AIEACKNLLK
RGIEEGHLKK DYKLLGHRQC IATVSPGRLL YEEITKWENF YPKDIHDDLK QVLCKNMSKL
PANKCDEIRS WLNSIDINED AELSDVEESC SVSVVESSII ESSSSSSDSG DEVALGQSSH
NHIKEYNNNL LPQIPALSFN NVNICNSSNV YLGNIYSVNG TLNINVINGE EKPQEDQEPT
AKKSPVIRPA CLIFPRYRWL AMDPLSESNK LPEPVEFISI GYTATTSSTV QARNIGIIRD
YQTLNVEAQG FNDIIYNFLI GCDGTIYEGR GWGVEGEHTA GYNHKSIGIA IVGNFKQELP
PERTFKACQK LITRGIEEGH LSKDYKIFAP PTANYNLLNE ELKKWDHFWD IKNCNES
//
