ID A0A0L0C379_LUCCU Unreviewed; 2628 AA.
AC A0A0L0C379;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Protein telomere ends associated {ECO:0008006|Google:ProtNLM};
GN ORFNames=FF38_11392 {ECO:0000313|EMBL:KNC26702.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC26702.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC26702.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC26702.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC26702.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC26702.1}.
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DR EMBL; JRES01000960; KNC26702.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0C379; -.
DR EnsemblMetazoa; KNC26702; KNC26702; FF38_11392.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.140.100; Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain; 1.
DR Gene3D; 3.40.140.70; Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain; 1.
DR InterPro; IPR032197; Atg7_N.
DR InterPro; IPR042522; Atg7_N_1.
DR InterPro; IPR042523; Atg7_N_2.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF3; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7; 1.
DR Pfam; PF16420; ATG7_N; 1.
DR Pfam; PF00899; ThiF; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 2104..2399
FT /note="Ubiquitin-like modifier-activating enzyme Atg7 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16420"
FT DOMAIN 2416..2584
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT REGION 150..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1827..1846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1860..1940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1874..1940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2628 AA; 300820 MW; 1C2C784D131232EA CRC64;
MTTKNIPVSF EFFKKYTYHE EWVERMLKVK ANGHQETYEA LLNSEESKEK ALRSYYEAFY
LKPQIREKSH IRLKAVPKKI KDKLLAIPVQ DASMENYEKV CDNNSNELVQ DAIGEIAVAE
QLKIGECSIS KNEEQKQRIL MTAKDVRDVD DGQVVEDDSE PLGSPDVSST PKLANANVNS
PVKIQCKELP LTLPTKALTS SDGNIKTNSK PVIGKIIEQQ TADTTKVLTD KQAELMETNN
NNNKPEMANT ETNKSPPMFN ADNAKHFNYK DLVPYIHCCP LTLKEFRKYS NIRQLTKELC
KTKHMDDKHQ RVIEQRSYIL FYLAPEHRKI TPLNKIQMLD NCPEYIKSKF FVIPTNLYLK
KQDTDKIQEN IESKYVYETE SVGNKEEHLR ATVTKAVTSK ETTEDVVEHN INEIASTEDV
PPMVVAENQQ LMPKDINKTN EQTIISCSTS HPTNEIKNLP VSLEEFKKLT HFEEVVEKLF
KIKAQDNEEL FNKYKNSQEA FNTTAFNYYQ AFYLIPIIRE TFPIRFKPMP SSLKNRLLQI
PKGIDKTTLN NFRIEELVSV ECNAAVEVEK ETVTASREEV AKASNNSNTS QTSPTNTSTI
TIKTEKDTES SDSDNKTNSL SAGSLKRNTT EDMKCPLRKR QKTQQTQDYE ENTQKTKKSY
KELLPYAHCC PVTFSDFRKY TNVSELFAGY CQKRYNSLKK LPYMLQRAYV LYYLAPENRQ
FKPFSKLITL DECPADLREK MHQIPEKLYL KGQNATEQMD IDEMQTETFK ENQSENLNPQ
QTASTNAKNK RNSIEILENR LLPPTHIPFT GQVNVVSQCL NNNCVFHYIT HVDFIQLSNI
LYILPEPSEI AIIQSFKKFV YRLLKEKSCE IEYNISASLL CKLFKYNKMC EICEKDVMAL
FKQDSLTACN ESANENSLTH AANNVTVNER MDSSNERMQT NQEATTVETD SRQSQAVHKS
SNTCSTESDT KSGQSPIQDT PQIQEKSQNL WKNLKSEKIF QKFCHKLLTK LKQSFDNAID
FSSDTYEIFL QCNEIPMEKL LNDFCLNNKD IVERILNNKE LYEALQCYFY YKYLTNTNFA
LKYPVTIKEN AKETQGDKSN TTITEPNKEK TPLKTNGFKN TTPKATEKQN NIVNQETKSP
EKPTNNNNII EKAKRIFFRN VEKTNTLSYI LCTSFGLKQL ILRTILSLTF QEFLQLTSIY
EGKQLYNDKH LTECMYRYVF DTPVVWPTNL FITLKDLCEF LHMKNIRFTD YSTMLKYISP
KLLHWSVLLS CTNILDCVKI DYEKRSGKLL DTDDIKTLKQ ECIEYYNRCW KYEKWLGGVP
LVNEEFYKDY LISNDQGDAT MLDESALQEI CVEPDEVSDD VALINNDTEE LEPDDSYQNK
SLDPNSAAEI RDEIPTVINP SQNQSIKEFN CVLLPNTQQQ IEMLPAEARV SNDPLNNSNN
GNTLNVTSST NSENYEVVCL GELIANDIKS EPNNSKLLTD LIFYEDENSN MQCEPFLQEI
VNLDDSTTEV GENLPPSQIE FSDAVPELML STDLANSESS NSIMNLAQRL PSSAESYNEI
PVTQQQFVQE QQNAPVIQMI NVSLRSSGEN GSQEKQQQEM NLKDSARELE IIKVNSQEFE
LLQTSLQSFA VYAEAQRFPS TFEETPTCSG SLRAEPTTSI VLQPELIEST SNMEHLNVPL
PSNEIPQEAA TLNASQPSTQ PNTSLPKRRG FEKTYARVKN GKSVATVRPI KNSNFVPQIQ
HNTRPLQTKP AYAPTTASET TTISEQPPCS SLTPIEEDNA VTNEQSVDNL PPVGTTIQIS
QEFQKNCSVF NNTSLLRLVD HNYQKQSQTS LSSSLPSTQT QNEGNHQQLQ TFSLTLTQTE
HKEATESQKQ QPARRSTRRS SMLGSQPTNP PQNTVSTTTT TSNQINPPAS PTRATRSRSS
LCKDANDKVN NPLLTSHTNN PIATIAPTPH LQQLHKMVTK LCLYRQINKF HYFKELTAQH
ICKYLLPSLE YGKSYTEATI VCENFKTRIS NRSISALFPF WSQSLQKDFL LVLSDLKEFH
YITFESERMQ KHDDLRVRIL YWLLSTAPSF ALCQFVCEAN NTEFSYCETI KNANNPSYKR
KPFNPTFWHK LVEIKLDLDR LSDKPKPIYG YYTNRHSKSC LMEVDYTAFN SEFTPPKYCF
KSHGTIYNKN TIEEFKNCDK NALLKEEGIK LLKHFQNEAT VEDPSLLARF FILSFADLKN
HNYYYWFAFP CPLTATLTLE KPASKLVDSR EKFDNVQEAI KLCPNGILQN LFVLQASATN
KKFYTLKEFI DNYKTLEKLP LEETYFCFPD NSEFVQPSWL MRIYAAFIYY KCSFLVGNTI
KFLGLRYGNH MNIGFSLIWH IKQSEILDLK EMDQIKFVGW ELNKNQKPQP RMVSMRDSMD
PQVLTDNSID LNLKLMKWRL LPDLNMEVIK STKCLLFGAG TLGCAVARML LGWGFKYITF
VDNGKVSLAN PVRQYLYTFE DAVKGNVFKA DAAADCLKKI NPSTVSAGHV MHIPMPGHTV
GDSLKQQTEK DLNKLQELVK EHDVIFLLTD SRESRWLPTL LGTAHEKIVI NSALGFDSYL
IQRHGSARKP GNDTSIAQME IDNLKCIPGH QLGCYFCNDV TAPGNAHS
//
