ID A0A0L0C8B5_LUCCU Unreviewed; 834 AA.
AC A0A0L0C8B5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Echinoderm microtubule-associated protein-like protein {ECO:0000313|EMBL:KNC28511.1};
GN ORFNames=FF38_05771 {ECO:0000313|EMBL:KNC28511.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC28511.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC28511.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC28511.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC28511.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC28511.1}.
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DR EMBL; JRES01000760; KNC28511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0C8B5; -.
DR STRING; 7375.A0A0L0C8B5; -.
DR EnsemblMetazoa; KNC28511; KNC28511; FF38_05771.
DR OMA; LHPSREM; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd17070; DCX2_RP_like; 1.
DR Gene3D; 3.10.20.230; Doublecortin domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF55; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE CG42247; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF89837; Doublecortin (DC); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50309; DC; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 58..133
FT /note="Doublecortin"
FT /evidence="ECO:0000259|PROSITE:PS50309"
FT REPEAT 556..587
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 834 AA; 92441 MW; 22DD439B89950DF9 CRC64;
MLLLKDPASY GKKNGMWYAS PGNQGWGSKP ASRKPSIMEA DLGTLSTTSG SIKRSAGRVI
RIINNLDHSV QCRVLLNLRT SQPFEEVLED LGQVLKINGA KKMYTGTGQE VRSFSQLRNE
FADVDTFYLA TGTALIAGSP IRRSRSRPSV MAAAPILPTE DLPKVPLRGA RPRSKSRPRI
LYAPESEILR TNGEYTMLDM MKEDPTKVTI RGLRRTFYPP AHHAPADNTP PDKKLQLQWV
HGYRGIDARR NLWVLPSGEL LYYVAAVAVL LDRDEDAQRH YTGHTEDIIM DVHPSRELVA
SGQKAGRDRK SQAHVRIWST ESLQTLYVFG MGELDTGVTA VAFSQLNGGS YILAVDSGRE
SILSVWQWQW GHLLGKVATL QEGLSGAAFH PLDDNLIITH GRGHLAFWHR RKDGFFERTD
IVKQPSRSHV TSVQFEPDGD VITADSDGFI TIYSVDSDGA YFVRTEFEAH TKGIGCLIML
GEGTLLSGGE KDRKIAAWDS LQNYKKIADT KLPESAGGVR TIYPQRPGRN DGNIYVGTTR
NNILEGSLQR RFTQVVFGHG RQLWGLAAHP DDDLFATAGH DKHIALWRKS KLIWTIQTGY
ECVSLAFHPF GTALAAGSTE GHLLVINCEN GAVMLTLRVC GSPINCVAFN QVGDMIAMGS
QNGSIYLFRV SRDGFSYKKV NKIRGSQPLT HLDWSMDGNF VQTVTIDFDL LFWDAKSLSP
ERSPIAMKDV KWLTSNCTVG FLVAGQWSNR YYSNSNTIIA TCSRSAAQDM LVSGDADGYI
RLFRYPCISP RAEFHEAKVY SGMVACARFL FGDQTIVTVG GTDASLMVWD LVEE
//
