ID A0A0L0C995_LUCCU Unreviewed; 1750 AA.
AC A0A0L0C995;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=SEC7 domain-containing protein {ECO:0000259|PROSITE:PS50190};
DE Flags: Fragment;
GN ORFNames=FF38_12849 {ECO:0000313|EMBL:KNC28841.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC28841.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC28841.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC28841.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC28841.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC28841.1}.
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DR EMBL; JRES01000739; KNC28841.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0C995; -.
DR EnsemblMetazoa; KNC28841; KNC28841; FF38_12849.
DR OMA; MENQVYE; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF375; LD29171P; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 637..827
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 231..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1468..1530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1750
FT /evidence="ECO:0000313|EMBL:KNC28841.1"
SQ SEQUENCE 1750 AA; 197250 MW; 144EB7003D6065EB CRC64;
MQSFSTKTKE MFIVRALEKI LADKDIKRSQ NSQLKKSCDT ALEQIKAELI NAGQIAEGNE
LPCAALPLPK NDAASIINAE TYFLPFELAC KSRSPRIVVT ALDCLEKLIA YGHLTGAIQD
SSSPGHLLID RIVNTICGCF NGPQTDECVQ LQIIKALLTV VTSQHVEIHE GTVLQAVRTC
YDIYLSSKNL VNQTTACATL TQMLDVIFSR MENQVYEVAA QAAQAAAAAN NGNNDANTSQ
ASEASVSVKS VSGTEEETPE SVAAAVVEEI LNAAINEVLK ETSPEIIIND EEQTAANNSN
STNNTSTNNI STTGSEGNAN HASSENNLHL NSEESAEMHS ENDAVVTAKF THVLQKDAFL
VFRALCKLSM KPLPEGHPDP KSHELRSKVL SLRLLLSILQ NAGPVFRSNE MFIMAIKQYL
CVALSKNGVS LVPEVFELSL SIFVALLSNF KIHLKKQIEV FFKEIFLNIL EATSSSFEHK
WMVIQALTRI CADAQSVVDI YVNYDCDFQA ANLFERLVND LSKIAQGRQA LELGANPMEE
KSMRIRGLEC LVSILKCMVE WSQDLYVNPN MPSLNAHEGT AHNRSANSAD LQSPTDNTDA
ISQTNTIGVR STHGGSSHSL NSYGSVKNTE VLDLPEALEE RKMRKEVMEA GIEIFNRKPK
KGVQFLQEKQ LLGSSPKDIA KWLHEDERLD KTIIGNYIGE NDDHSKEVMC AYIDAFEFHN
LEVVSALRML LEEFRLPGEA QKIDRLMEKF ASRYCECNPN NPLFQSADTV YVLAFSIIML
TTDLHSPQVK NKMTKEQYIK LNQGVSDSRD DLPVEYLSSI YDEIAGHEIK MKNTVVNKPG
KQIIANEKRR KLLWNMEMEA ISTAAKNLME SVSHVKSPFT SAKHLEHVRP MFKMAWTPFL
AAFSVGLQDC DDPEIACLCL DGIRCAIRIA CIFHMTLERD AYVQALARFT LLTANSPINE
MKAKNIDTIK TLIMVAHTDG NYLGSSWLDI VKCISQLELA QLIGTGVRPK FLSGAQTTLK
DSLNPSVKEH IGQTSSQSVV VAVDRIFTGS IRLDGDAIVD FVKALCQVSI EELHNTQPRM
FSLQKIVEIS YYNMERIRLQ WSRIWQVLGE HFNTVGCNTN EEISFFALDS LRQLSMKFME
KGEFANFRFQ KDFLRPFEHI MKKNQSPAIR DMVVRCIAQM VNSQARNIKS GWKNIFSIFH
LAAGDHEEAI VELAFQTTGK IIGELYQKQF AVMVDSFQDA VKCLSEFACN ARFPDTSMEA
IRLVRTCALC VHESPQLFAE HAGMENDISV AEEDRVWVRG WFPMLFSLSC VVNRCKLDVR
TRGLTVLFEI VKTHGDSFKP NWWKDLFNVI FRIFDNMKLP EHVTEKSEWM TTTCNHALYA
IIDVFTQYFD VLGHLLLEDL FAQLHWCVQQ NNEQLARSGT NCLENLVISN GFKFNEATWD
KTCQCILDIF NATLPGELLT WRPNPQLQQQ MQLQQQPHHQ TQQGQVQYQT AAHNNPQTPH
LRKGSNPRAN DTLNRSYSQH SVYSNSGSFD DDHTHQTHHQ HHLHQQHPHA TPQHPIVPQN
PALFESLNIK CVVQLELIQT VDNIIFFPAT SRKEDAETLA QAAADLTGNI TTHPMLDCQR
EEQGMYSYLR TRQLLTLADC LMQSHRFAKR FNADQEQRNI LWRAGFKGSI KPNLLKQETA
SLACVLRIFF KMYGDENRRS DWPGIEQELV QVCKEALTYF LSLQSEAHRD AWTSLLLLIL
TRLLKMSDAR
//
