ID A0A0L0CEV9_LUCCU Unreviewed; 4647 AA.
AC A0A0L0CEV9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=FF38_11774 {ECO:0000313|EMBL:KNC30752.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC30752.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC30752.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC30752.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC30752.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC30752.1}.
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DR EMBL; JRES01000501; KNC30752.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0CEV9; -.
DR EnsemblMetazoa; KNC30752; KNC30752; FF38_11774.
DR OMA; LHCHFGE; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 2.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 2282..2418
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2561..2692
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2824..2977
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 64..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3402..3450
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3618..3669
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 64..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4647 AA; 534717 MW; 8F2BDBA4F2D28AE1 CRC64;
MLGVYEPEYV NAAIYENLYD FKSFLNDKYT KNEDINKIIL YVWRTFYDKL VEEEITVLEE
VPPELPPETE KKDKKSKKGK GKVMTKEKDV KSNVKSAIEK EPKGGRPSSM GKIKSSDAER
NSTKEATDTG IESATEDVGA ESVKSSALSA SDEDDDEIGS KKSGKGKGKR KKRKTLVAPS
PVYVEVKKII PTFVKTPILH CHFGELKCSH FNNNIKYVYV IRKEVSGIPF YTDINKCFAE
MSQYFIFGTV RGSLLDSMRI DIDKIFKHAI KFQFREPKLI ESEQFENCET HPLSKSRNAA
DSTEVKEMAP GLLELSKPSE FRMKALKQKK KMEKLAARRR SEAHKKALGK SMKKGQSGIN
TSHRNGSGNG SENGDIVDED EKEEINVDDA AKDSVSMGSI DEDLDKRPEV TLTIGERWEK
LLRETHEKVK RHHIEAENVM EKRPPHKEAF FNQLKDFEQE IEWTTNHIVW AFNLPTSYAA
PGQDHIEFEE SKVRIPIDVK KINSIPTYSP EQLEDVVDGW IRYMKKTIKT LDEKPLDEFT
PMAEYHLWHF REIELNTLLE QLKSGFVVAV LDTLTSNQSK ILQRWSETLT KINDKFRLAK
ENADYVGTIT DYLEKIRSYE SFKMTTLLIP NVMVGLRHIW TMSSYYCLDD KMQVLLCQIS
NVFTEKVKNI VCFEKIFRYS SKFTYETATN CANLLKCWKT AYLLSRKHIE ESGAGSRWEF
DRNALFNEVD HICRISRDIA SIGRVFVQYE NLFGKRLKGL ITHPPLIDDL MRKVYRLLDD
MLISVDYDIF QPGNWENWEH TLSTFNKRLD TVESEAKLVI ERSITMLRSS ELGLSLIRDV
KHLDTRQALT EFISTKHENI LRFFVTEINA VEYEYMNNKK APPIGKHQPA KIGAIQWTRL
LSAKLKISVL AFKRMENEPN LKNSYLKRSA FKSYFELVNK MYTYENSLFE KYCSQATYMV
NVVMRKNILT IQICNKDTLS YISNALDTIK LKRIKSVDLN VNATTNEQYA HAAPTGFIRK
ITKFTVIATM IQWFVGRKTS ADAHILKAIQ FLKLMKSGKV RPSEKDKFCI KQCELLVKAS
TQEGLPTWRT LVGERILIEF EMQFTVNLTR DIFEVMFEGQ QFEHFGFQLP SVLRTAIMKK
EMLFNDFEAV STVINNYNAL LSKLSLSEVN FLRDHLYEIE VAVQVGVGRY AWQSFNIRKY
CSGVNTLMRK LQSIVSQINY IRDDIRHRIE QIKTFNIFLI DDIDSSTEAT IQFKDTGSSG
VICEEADQSG KESRVEIIRI KESTESLLSS KRECGIATYH CQGYMERLEQ SRTEKCSRMK
KIYDSLGPVL IKLESLVLGT FTGRSEKMRN YYVFWEEETY KCILDFTYKN LECFLDRLTG
KEPMFEINAV LVLSEIMLEP TSNEIKNMIV QAAKDFLERL KMFTRWMDGT CLACAPVEHI
GGQKYTFTFY EDVIKIKNIG GLLVKVQELA NRVVEDAKKC VKKFRKYYNL WAFDKETICE
KYVNRGVPLV QLDEKFTFYA NIMDELQHLP KHYDVQCIRI NLKPLLDTIC QHAQQWRTKL
GEKLAERTIA NMDKMRFEIK VLSENLNKAT KELCDFKLVM QTIATIQSTT LTREITIREI
QETYTVLSEH NINFNFEDML MAHHLEKRWM RLYRSSLYRL DKLQPIKQKF ADMTSVEISG
FWKELQEFIM DFEKNGPGSV AGDLDRGSKL MEFYGQKINE FDARRQELAN AEKLFDMPMQ
DYNEFSRIKD DYEGMQIVYK LYKSQKAARE GWSKTLWADL DPSVLTEGVE SFLKEFRKLS
KQVRQLTVGQ MLELQMKQFK GTVPLMVSLK NEALRERHWL QLMDKTGQYF DMTPERFTLE
NMFAMQLHKY QEIAEQILNN AIKELAIEKG VKAVEDTWAI MNFKVHKHYK GIEERGYTLG
AVDDIIQVLD DNSMNLQSMG ASQFIGPFLE TVNRWERNLA LISEIIDEWL VVQRKWLYLE
GIFIGGDIRS QLPDEAKKFD DIDKAYRRIM LDCAKNPLVV IFCTIPGRLP EIQGLSIGLE
NCQKSLNEYL ESKRRIFPRF YFISTDELLS ILGSSEPTAV QNHIIKMYDN VKSLRIIKES
VNIYTVNAMI SSEGEVLDFR RNSKPDWLMK YQSMVGLVAS QVWWTAEVEE VFNQAKNFGN
LRAMKDFLNK QNYQMDELVL KVRSDLSSND RKKFKTIATI DVHARDIIEA FVRDNVLDVG
EFSWESQLRF YWLKLYDNLF VIQCSGRFDY GYEYLGLNSR LVITPLTDRI YLTITQALLM
NLGGAPAGPA GTGKTETTKD LAKALALLCV VTNCGEGMDF HAVGTILSGL AQCGAWGCFD
EFNRIDISVL SVISTQLQTI RNALIRKLQR FVFEGCEIKI DRKVGIFVTM NPGYAGRTEL
PESVKALFRP VTCIKPDLEL ICLISLFSDG FLTAKILAKK MTVLYALAQE QLSKQCHYDW
GLRSLNSVLR MAGVMKRQSN DLPEAVVLMR VLRDMNFPKF VFEDVPLFLG LIKDLFPGID
CPRVGYPDFN AAVRHCLVND GFILLADQED KVVQMYETMM TRHSTMIVGP TGGGKTVVIN
TLIKAQTFMG LPTKCITLNP KERRYVCFDG DVDALWIENM NSVMDDNKLL TLANGERIRL
ENYCALLFEA IAFIHEGLDG TSQGNPLKTV IMQTELNMIV QFCNMYDALL PSFEKLDDLS
FGAPPPVQYD TDTLECCFIQ CIYSSLGACL VEHDQIIFDE FIKRISGFPC VQDAKDKPAS
GGQLPTCKPT LYEYFYNRET SCWMAWEWVV PRYVHDPNTK FSEILVPTVD STRTISILNL
NSYIKRPVLL VGEAGTSKTA IISQYLRNLN KDVNIILNIN FSSRTSSMDI QRTLEAAVEK
RTKDTFGPPM GKKIACFIDD MNMPQVDDYG TQQPIALLKL LFECGGMYDR DKDLNWKKFK
DLTFYGAMGC AGGGRNDVDP RFISMFSVYN IVFPNDESLL QIYVSIFKGH LQHGGTFNPK
LIPIADIIVQ MTLRLFKDLE LMRRQVENEI RETFSPDFEV ENGFVDPKAQ AEEAANLEQY
GAVDFEQDEK TIVTLTDHVM RDPCLFGDFR NAANESEPRF YEDLLDYEAV YHLFNEILEE
YQERKGKMAL VLFEDCLEHL TRVHRTLRMH RGHVLLLGVG GSGKKCITRL SAFTAECEVY
EITVTKGYNE QSFRDDLKVL YIMAGVERKK TVFLFTAAQV VEEGFLELIN NVLTVGLIPA
LFNDEEKDAI VSGCRIAAEE SGYLASKESV WSYFLATCAQ NMHVVMCMSP AGDALRSRCR
NFPGLIGSTY IDWVFPWPAQ ALSAVAKLFL TEHALIPSIH RGSIIKHVVY VHSTMHHYSK
DYLQKLRRNN YVTPKHYLDY INTYLKLLEE KNTFISSQRD RLKEGIQKID EASKQIDELR
IIVTEQKHNV ARASEECEQM LVEIEDATTK ANIKKTEASE KSVEVEIKGK QIAVEKEEAE
IVLADALPAL EEARRALSEL DKAQITEIRS FATPPPQVQV VCECVVILKG IKEINWKSAK
GMMSDVSFLK SLMEMDCEAL TGKQINQCRN HMKSQNLDEM EKISVAGAGL LKFVRAVIGF
YEVYKEVKPK KERVDFLVQE QEQQIKLLNH LNNEITKLEA QLDSLNHRYA ESMKQMKVLT
EMMQQAERRL IASDKLISGL SSERVRWSLD FDNYGHQLVV IVGQCLLCAS FLAYTGAFSW
EYRKTMMFDD WLEDIKYNKI PIQIPFRIDE NLTTDIEVST WSSEGLPPDD LSVQNGVLTV
RSSRFPLCID PQLQAWTWIK RKEQKNNLKI LSFNDSDFLK QLEMSIMYGI PVLFEDVDDY
IDPVIDNVLQ KNIQIASGRK FLILGDKDVD YDPNFRLYLT TKFSNPKFDP AVYAKAMVIN
YTVTQTGLED QLLSVVVRAE RPDLEAQRET LIAQTSENKQ LLQQLEDSLL RELATSTGNM
LDNIELIDTL ENTKSKAAIV LEQLKLSAET QRDIEKLRDG YRPVAKRGAV LFFALSDMST
VNSMYQYALA AYLDVFTFSL RKSVPDTVLA KRLNNIIKTL TENIYCYGCT GIFEKHKLLF
SFQIATKLAL RDSILSQAEL DFFIKGSVLL TKSDRTCPAK WLSEKNWEDI LRLAADFPDP
FETLPEHVLK FTKEWKEKLM FLRCFRIDRI FRSINQYIVD TMDEFFITPP VVSFAAIYEQ
TTCFIPVCFI LSTGSDPTND LMKLAEQSGG GLGNFCHISL GQGQEKERRK YDKLGWNICY
DFNESDFNVC LEILQTYLNR INDDSVPWNS LKYLIGEVMY GGRVIDDFDR RITRTYMNEY
MGDFLFDSFQ PFYFYRDEHT EYCLPNEDVI LKEDFIAHID KLPLVNKPDV FGLHPNAEIG
YYTQATRSIW NSLIELQPQT GDISGGISRD EFIDNVASDI LDKLPTAFET WRVKKQIQMS
LTPTGVVLLQ ELDRFNLLVL RIKKTLELLR KASEIGMDNI LDNIANSLFN GLLPADWRKL
APDTCKQLGS WLEHLQVACR KNGWPLDKSQ MYTCVTNFID PDDIEERPTT GCYITGLYIE
GARWDLEQMQ LDRSHPKILV EELPILSVVP IEAHRLKLQN TFRAPVYMTS QRRNAMGVGL
VFEADLVTSK DLSHWILQGV CLTLNKD
//
