ID A0A0L0CH98_LUCCU Unreviewed; 776 AA.
AC A0A0L0CH98;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Ras-specific guanine nucleotide-releasing factor RalGPS1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=FF38_01616 {ECO:0000313|EMBL:KNC30859.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC30859.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC30859.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC30859.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC30859.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC30859.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JRES01000487; KNC30859.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CH98; -.
DR STRING; 7375.A0A0L0CH98; -.
DR EnsemblMetazoa; KNC30859; KNC30859; FF38_01616.
DR EnsemblMetazoa; XM_046954891.1; XP_046810847.1; LOC111688719.
DR OMA; MVLCFSD; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13310; PH_RalGPS1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF368; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 220..456
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 647..759
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 21..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 87211 MW; 3BD2B41B40C92A19 CRC64;
MMRYSEISRE LSNDNLRYVE FGSGSGGSQQ DDCPLNVTRE TSPMSDISTG SGPLVNQSPA
SSCRRHHHQR LRSIQRYYDD HYDNISLGNK NNFSGFYAGL RSSKRFSSGG SNGSVNGTAN
GAATIAYVRQ RKDSVQSTQS FQFEAESPHK QNISKSLNIK GTRRKNSIGC LNAFSSSPDS
PSNYYGVGSG PPSLKSNSLP GHASSKTSLD STILSALRIP ADELANQLTL LDFPIFAAIQ
PDELTSCAWT KKDKHVITPN IVAFTKRFNH TSFWIVQEIL SGEQPKQRAE ILAHFIKVAK
KLHELNNLHS LFAIISAMQS ASIYRLKKTW TCLAKKDKQS YERLSDIFSD QNNWENLRAY
LESLRLPCIP YLGLFLTDLI YIDLAYPQKD GIEPESRRIR MNNILRVIAN YQESNYKQIQ
PVEATQKYLT SIRYIEELQN IFEEEQYKKS LKLEPISPLV PSSSSCSSKE SFNVDAVTPA
LACLNLSPAK TSASVRLPNS SAVKFIPGHR KCRSLGTKFR STSLPRNFSQ KCHCSLIMLT
KSGIVVNATA THKRCPCHCR IFGKTNIAND AVVGQNGACY DAHYHDHSAL SQQLQQRHLL
DDSVLEQPQC GSGTPNGSIH INLSDNNEVI ACHLHDVNNL NIPTDETNSL QGCVRRKTVQ
KEGRKPAVAS WQRYWLQIWA NSLVYFPPKS FKGSERNDFK REPCKVCPLE GWFAQVIDNP
KHKNTFELYH RTLGTIYKFR TDSPQTTQLW CSTICKLALQ QNRTPKTLPI NLMSFE
//
