ID A0A0L0CL65_LUCCU Unreviewed; 710 AA.
AC A0A0L0CL65;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=FHA domain-containing protein {ECO:0000259|PROSITE:PS50006};
GN ORFNames=FF38_05141 {ECO:0000313|EMBL:KNC25429.1}, FF38_07148
GN {ECO:0000313|EMBL:KNC33040.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC33040.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC33040.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC33040.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC33040.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC33040.1}.
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DR EMBL; JRES01001117; KNC25429.1; -; Genomic_DNA.
DR EMBL; JRES01000240; KNC33040.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CL65; -.
DR STRING; 7375.A0A0L0CL65; -.
DR EnsemblMetazoa; KNC25429; KNC25429; FF38_05141.
DR EnsemblMetazoa; KNC33040; KNC33040; FF38_07148.
DR OMA; CKDLNSG; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:InterPro.
DR CDD; cd17741; BRCT_nibrin; 1.
DR CDD; cd22667; FHA_NBN; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.10980; Nibrin, BRCT2 domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR040227; Nibrin-rel.
DR InterPro; IPR032429; Nibrin_BRCT2.
DR InterPro; IPR043014; Nibrin_BRCT2_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR12162:SF0; NIBRIN; 1.
DR PANTHER; PTHR12162; NIBRIN-RELATED; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF16508; NIBRIN_BRCT_II; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 22..72
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 325..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 595..622
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 364..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 80487 MW; 182A63B62DEFA1E5 CRC64;
MWYITHATSD QSVCFLPEKL KYSVGRLGAD VELQDDICVS RAHAAFHLVE TAVDQYKLEL
EDLGSKYGTF LNKDIETNTA VAKGRKIPVK NNDLVRFGRL QNIWKVQFMI IKTATSSLNR
DDSLQLHRYI SALGGTILDE WSTECTHLTM TDTCITMKLL HALVEQKPVV TLAYWKDLLN
AANGVKVHLP KPELYKPDFE DDEINLNCNI KRKSLFKGYT FVFLNRKHYD TYSPIVRAAG
GACKDLNSGV QKAFLIKDKV VVVEYTPSTQ TQSSQTISTI ADFLESNSKR IIPEYEIGFA
ILRCSLKTYC NPSYKMPNTA ASLAASETTK DSNQIDLTEE HSTPSLNTES MDLVISETNE
NIVTSTPYVN PDNINPSPNK EGSGVASESE KPQENQRKRK VMSVDLNESD DDDLFQFQSK
KTCTKKVDDE TIKARATDTE PVQENLNKSS TINVFLQKTQ NKNKTQSTLD QTVDQPSTSK
ETRKRPLIQV LNDDDEGNDD DLFSFGDTQK KKARKENNEE GEDDDLFSFK EKEAPTVAKP
IRTIEVDEDS NDMEPTQQFI VVTKKPSIQM PKPKVLPRKI SAIEWISSSL GKINIKKENN
ALIKSENDNE NEKDNIIKTE SEIKTEMGAE ITITEDHRKW LESLKDAIEI QQVSLNNSMK
NSDKSHYKFK NRSNDTTENL NDTVPNFKRF VKKYHIPSQN NSTGIKLHLR
//
