ID A0A0L0CNE9_LUCCU Unreviewed; 1789 AA.
AC A0A0L0CNE9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=FH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=FF38_07787 {ECO:0000313|EMBL:KNC32949.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC32949.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC32949.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC32949.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC32949.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC32949.1}.
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DR EMBL; JRES01000254; KNC32949.1; -; Genomic_DNA.
DR STRING; 7375.A0A0L0CNE9; -.
DR EnsemblMetazoa; KNC32949; KNC32949; FF38_07787.
DR OMA; PHDGHNS; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR027649; Inf2.
DR PANTHER; PTHR46345:SF8; FORMIN 3, ISOFORM B; 1.
DR PANTHER; PTHR46345; INVERTED FORMIN-2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000037069}.
FT DOMAIN 1..251
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 358..774
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 257..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1592..1789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..331
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1010
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1465..1569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1616..1789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1789 AA; 198868 MW; 648488BA0BA9BA53 CRC64;
MDSRIGLDYI VENRDYISKL GTALDTNNVV VKKQVFELLS ALCAYNADGY ARAIETLEYY
KNLKNERYRF KIVINELEKT TTIEYQVALL AFINCVIISA ATLQDRIRIR NEFIGLKILP
LLNSLSNNIN LLFVFVSFFF NYRKVAQSVG DIIVQLDVFD EQRECDEAQS LQGPNGINLN
SHLDVFYAIL RQVADTPQEI PFLSILQHLL RIDPKEPVSD VIWDTTEKLV HRATLLENHE
DSVRLLRTTN AQKFTCQNCR SDATSPTRKP NGPIAPPPPP PPAPAPPAPP TSCLNAGKGA
PPPPPPPMKM CNGPPAPPPI PGAPPAPPPG GKLLNVKNSM PVRSLTPEPR VNDVLLPQQD
TPAPKAKMKT LNWGKIPPHK VLGKQNLWTI VANNHQDNSM EDLDWNEMEG LFCLQSTSAQ
GSPKLGRADS GNGNSAVGGY DTLDRKSKKE STEINLLDGK RSLNVNIFLK QFKGYNSNED
IVQLIQDGNH EIIGAEKLRG LLKILPEVDE IDMLKTFNGD RQRLGRAEKF LLLLMEVPNY
KLRIESMLLK EEFAANITYL DPCINAMIEA GDDLINNKTL QEVLYIVVVA GNFLNSGGYA
GNAAGVKLSS LTKLTDIRAN KPGMNLIHFV AIQAEKRNPA LLNFTNELST LENASKTNVE
QISIDIKNLD TQLQKIKKQI ELPNTDEDIK DQMMEFLESA ESEISVLKSG MDAVESMRLK
LADFFCEDPA TFRLEECFKI LQTFCDKFKQ AVKENERRQQ LEEQATLRQK QREEQLARRA
KYANQNGTPI SDYDNQYSLD SSFDARASPA LSRKRFGSFN NGNLEINNSF IRMEATNGNC
DGMSPDITPN GSMRRRRSRV LAEEDDLMEF LRTSGHERNS RERKAAYGSL DRSWARRARS
GSSSRKRPEL LNIDFGADRE RAASPLPINV PEKASPLSPS NGEIVQPAQD ETKPRISREW
RQKIETWLQS NENDEKQDEE YKRKRRLVNI NRRSLENESE SERKLDTLPE EKFVPTTPNP
CTNDTNNTNS SNNSQTKDGY KRVYPDWKPS KTLDTDVVGT IQAIADVNNA RENSYKQREK
PSITEADDVS FTKSSTLVNN VNKSEDVVYR RQRSIENNAT QLESIAEEDR RKSLIQQLGE
RDATDRLKIY IRSPSTMEKD HSVANKQRLN GVDALKSPPS IYEAVAAETA STTKVNAENH
IKSPISKNRT ANNSQQKFNF DNVPSSSEVS KLESNTSNKI HNQTSHKAIT ASTNRKEIDA
DNIETPPVTR RIISSPTTTL VTVNRTEPKT QTESNNDVET TETPGHFDRY SMARRTRRYK
RPTDYSSGNE DLTSAKDSSE ENSLTQLAKN SSTEIQTKCE EKPLTTTNTA DKISENPKVK
RTNISAKTIT KLEKVGRHIS SINQEDVQEA LRNLKSPTDC PERLWSPPRE IIAQRTVNCN
NTTTTANGTT LIKISNHELN DEGFEETQSL VSDTPSHGKE STNSSCNEVN ELPKLSQKSL
SQKTTPIQKI SSRLADRLQI SRLRSSSTAS KSQPTTAASS PRRTASSVDR ARTSRMPNGQ
LVQGPASSTA AAHMSNFTNN AIRRATSMRK TIANSEPSSS SSGSTKRDVE RSSSRNSLRS
SRSSINSGAS TQTVKRMPIG SSHLNKSPLQ TVSVDSSPSK RPLSTQNLRN NPTRLSSTGG
VPASRSSSSG SSVGPNIVVV RRLNSTQSNV NQPRHTSSSN LGSTSFKENQ TNVGPSSRSQ
TARSALMAKA NVGNPQNSTR TATSRSSSST RGVSSFMRPT AASTTKRTK
//
