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Database: UniProt
Entry: A0A0L0CQ54_LUCCU
LinkDB: A0A0L0CQ54_LUCCU
Original site: A0A0L0CQ54_LUCCU 
ID   A0A0L0CQ54_LUCCU        Unreviewed;      1404 AA.
AC   A0A0L0CQ54;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   16-JAN-2019, entry version 16.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   ORFNames=FF38_06849 {ECO:0000313|EMBL:KNC33574.1};
OS   Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Oestroidea; Calliphoridae; Luciliinae; Lucilia.
OX   NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC33574.1, ECO:0000313|Proteomes:UP000037069};
RN   [1] {ECO:0000313|EMBL:KNC33574.1, ECO:0000313|Proteomes:UP000037069}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LS {ECO:0000313|EMBL:KNC33574.1,
RC   ECO:0000313|Proteomes:UP000037069};
RC   TISSUE=Full body {ECO:0000313|EMBL:KNC33574.1};
RX   PubMed=26108605; DOI=10.1038/ncomms8344;
RA   Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R.,
RA   Murali S.C., Hughes D.S., Lee S.F., Perry T., Stroehlein A.J.,
RA   Ansell B.R., Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L.,
RA   Chao H., Dinh H., Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M.,
RA   Ioannidis P., Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H.,
RA   Kotze A.C., Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT   "Lucilia cuprina genome unlocks parasitic fly biology to underpin
RT   future interventions.";
RL   Nat. Commun. 6:7344-7344(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675,
CC         ECO:0000256|SAAS:SAAS01116863};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KNC33574.1}.
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DR   EMBL; JRES01000175; KNC33574.1; -; Genomic_DNA.
DR   EnsemblMetazoa; KNC33574; KNC33574; FF38_06849.
DR   OMA; YWRVKDS; -.
DR   Proteomes; UP000037069; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 4.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 2.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 2.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51445; SSF51445; 2.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000037069};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     33     55       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    708    733       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       76    397       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      760   1081       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN     1310   1348       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
SQ   SEQUENCE   1404 AA;  160296 MW;  E068EA01ED93F930 CRC64;
     MVEPESEVAT ITPTNATKES EVPKNKKIET NDIVSIVISI ICVILIVIII YCLFVHFTEV
     ANQERTFTVD HVGNTFLMNG KPFRYVSGSI HYFRAVPEAW HKRLRSMKVA GLNAIDIYVE
     WSLHNPHDGV YDWSGIANVE RFIRLAQKEG FYVILRPGPY ICAERDNGGL PYWLLGKYPG
     IKVRTSDANY THEVSLWYSQ LMPRMQPFFY GNGGPIIMVQ VENEYGSFPA CDREYMKWLR
     DETLKYVSDK ALLFTIDYPA EELECGRVDD VFTTIDFGVE ETQDLDKVWN TLRTVQPTGP
     LVNSEFYVGW LTHWHEKNQR VEPQAVAEAL RSILASNASV NMYMFFGGTN FGFTAGANDF
     GHSKYVPDIT SYDYDAVLDE RGNVTRKYEL IRDVLRQYFR VSKMKPVREQ TYAYGKVDLK
     PIMNLLSPLG RSSLGKSELE KSLKPKSFEE LDQFSGLVLY ETSLEGMAIE NSTLTVNDLR
     DRALVYVDQE FAGILSRQSG NYSLTLKKSF GSTLQILVEN QGRINYHIAN DTKGIMGTVT
     LKNNKGVIRN LENWLHTAYS LEEVLVQKLL SASLKPFTEN HYLLYQGPVV YYGEFYVKKP
     HHTFLNPTGW GKGVAYVNGF NLGRYWPLAG PQLTLYVPQE ILLRGRNTLI IIEYEQTNRA
     ESNILNRDSV RYAASMNQCR SALLDVEVQQ PVEVEPSKKK NKIMRSDIIA MVVSGVCAVL
     IVIILYSLIM HFVGASEHIT LNPNVTMNRT FTIDHEANTF LMDGKPFRYV SGSFHYFRAL
     PDAWHKRLRT MRSTGLNVLD TYVEWSLHNP HDGVYDWTDI ADVERFIELA QKEGFYVILR
     PGPYICAERD NGGLPHWLFG KYPGIQLRTN DANYTHEVSV WYSKLMPKMQ RFLYGNGGPI
     IMVQVENEYG AFHACDRDYL NWLRDETLKY VEDKALLFTT DIPDERIQCG KIEGVFATTD
     FGIDRIHEID NIWSILRSVQ PTGPLVNSEF YPGWLTHWQE QNQRRDGQLV ADALKKILSY
     NASVNFYMFF GGTNFGFTAG ANDFGDHKYV PDITSYDYDA VMDEPGNITK KFELVRDVIA
     QYFEIPKVEV IKEQAFAYGK VNMRQVMHLL SNEGRATLGK AVDNELAVKS VKPKTFEELD
     QYSGLVLYET DIGDLNMISP ILTVNDFRDR ALVFVDQKPM GILSRQNGNN SLILNISTGG
     SKLQILVENQ GRINFNVAND TKGIMGKVTL QKTKDGEEVN LENWFNTRFP LEEPQTSNLL
     NSIYKKYTSL EFTPEDESVL KHGPTVHYGE FMVNEVHHTF LNPSGWGKGV AFVNGFHLGR
     YWPKAGPQLT LYVPQEILYT GTNSLLLIEY EQTNRVSKDI DPYVTLDDKP QLDLLLEDSE
     ETTVSAPAYK ENTKVTSVFF IHGE
//
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