ID A0A0L0CQ62_LUCCU Unreviewed; 1095 AA.
AC A0A0L0CQ62;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Integrator complex subunit 12 {ECO:0000256|ARBA:ARBA00016814};
GN ORFNames=FF38_02758 {ECO:0000313|EMBL:KNC34505.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC34505.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC34505.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC34505.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC34505.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SIMILARITY: Belongs to the Integrator subunit 12 family.
CC {ECO:0000256|ARBA:ARBA00006009}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC34505.1}.
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DR EMBL; JRES01000062; KNC34505.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CQ62; -.
DR STRING; 7375.A0A0L0CQ62; -.
DR EnsemblMetazoa; KNC34505; KNC34505; FF38_02758.
DR OMA; HATPMGK; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005537; F:mannose binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007041; P:lysosomal transport; IEA:InterPro.
DR CDD; cd15501; PHD_Int12; 1.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 4.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000479; CIMR_rpt.
DR InterPro; IPR039054; Int12_PHD.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15071:SF0; CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR15071; MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF00878; CIMR; 5.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM01404; CIMR; 5.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 4.
DR PROSITE; PS51914; MRH; 3.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 126..183
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 339..479
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 487..628
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 764..952
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT REGION 192..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 121318 MW; 9985155A9E44502F CRC64;
MSTTNEIEIL LKKAVTLLHS SHANSATELR LLLDEEIKKR YGSEKTITNS LSKKQLDDEA
NFPGRAATPP PQPVETEEVI NLIHSPAKTI SDSPDTIADS DDAVSGAGGI LSTTAEDETN
LKEFGDLNCC VCGEIRFTAT NRLIECSKCG ALYHQECHKP PITDEEASEE QGHNWQCDNC
IGKPTMTTAT ATTKLSGSST PGVVVIPDEP MPLITNSSVP SIKSKSSATS SRSSSSSNSS
SPYHKMEHVQ VVNSVVGGKT SSSSKSHRED RMSTGSSSSK VTAINTSSIS STSSTNKKHS
SSVIMFKDLT PIWCLLLIGC KVMHAASVGN ENPLILSTNE CSITEPVYGH KFDFSALHSD
FAHLTRSDLG DTFEFNICGN ITRKCNNRSD VAACLKRSDN KEYILGTQHQ LNYHNGKMYF
SFSNGEKCSS SNKKDETYQL HVFLGCDYTL DKNQSRVTSY APDACSFYIT FETPLACLPE
PDSVKGNICN VHDSSTGHTF DLMPLSDNNY RTIDRQGNVF VINICKPVLY GENAMCPADS
SVCFLKLNET DYKKKFINYG TVQPKPVLEN GHLIMRHISP SPCNTTTNYS STIYFYCDKE
VKNAHPELMG LHGCSYEFSF LTPLACNDFP PCTVITHDNE IINMSSLMDK PFKLQQDNQN
YIFSVCSSAG SPCMENDGAC LFNNQSNGLG MFNTNLRINQ TGAPYLLYEN GVICTDKENT
KWSTKIEFVC ANKTSNSMGP KIIENSHCQL LIHYETDLAC QEQIDCKAKV YVEHSEDVAD
MELIDLTPLI NTVDNYEAEI DSNTITAQQV TKSTKFFLNV CRPLVPKNGL GCKGGTAVCM
GKIDSNTGKL EEEQALKVTP AMLLEEEKKQ EKQEAEAKSL GFPLASLVAV NRTNAQLRYL
MGDICPEDKN LLLSSRIEFY CNMRAGRGTP KLRKYADCHY EFTWATNVIC PPHMCDFEEK
TCEIKNSELG VSYNLKKATF GHEGKIKISK DNKEFTLDFC DEKNVHKAVT DYSQGLVNLF
FMTNGSCNSN GLINVQMRLI CSSSTEEPLT SFSGIKVFWY EEYSAGRIRN KFLQIFTINV
KYTPILLLKD YNSSE
//
