ID A0A0L0CRR8_LUCCU Unreviewed; 777 AA.
AC A0A0L0CRR8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Testican-2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=FF38_11074 {ECO:0000313|EMBL:KNC34907.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC34907.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC34907.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC34907.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC34907.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC34907.1}.
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DR EMBL; JRES01000007; KNC34907.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CRR8; -.
DR STRING; 7375.A0A0L0CRR8; -.
DR EnsemblMetazoa; KNC34907; KNC34907; FF38_11074.
DR EnsemblMetazoa; XM_046947765.1; XP_046803721.1; LOC111688959.
DR EnsemblMetazoa; XM_046947766.1; XP_046803722.1; LOC111688959.
DR OMA; RKMRNYN; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd16232; EFh_SPARC_TICN; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR13866:SF27; KAZAL-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13866; SPARC OSTEONECTIN; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Heparan sulfate {ECO:0000256|ARBA:ARBA00023207};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..777
FT /note="Testican-2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005536896"
FT DOMAIN 379..430
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 678..742
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 132..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..193
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..304
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..769
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 714..721
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 777 AA; 87700 MW; 188D2E3A8F8E5053 CRC64;
MNTLMCLMTT MGLILLMSSS QGVEAKKPKK YIGENGGDFE FIDEVNKNAQ LSSSGKNNGG
GGGSILNSMG LNGERKRWIH DPTSDLCRPL SCKKREICLL ENEYSAVCVS KKELHKNRDE
IITKSKYLEE QAKRRAANQH DNLHLNDNLN SNNVNNNNNN INMNNNNNNN NVDNDDEDED
DDEDEDDMDV SNGDDNNVDI LTTNDDLNFN MNNKNNNNIN GNNNNFNMNL NNNNNNNNEE
IESKEDDVFY ESNAGLDNNK NNEDDEEEDP IPSPIPSPIP SPIPSPIPSP IPSPIPSSIP
SHISSPIPSP IPSSIPILSP IPSFIPSPIP SLSPIPSPIP SPIPSPIPIP NSIPIPIPSP
IPIASPTLFS VLSSYLTSKN KTNNCKPCPV AKPTFLCGND NRTYSSLCRL DYHNCIHSTS
IRIACKGFCP CKDNISEKRL QRINERQNAF NAKYKKTMEQ QQEKQQQQYK ENSNNNIISS
SNNNEFNTIM DDKDDNNRHY NHINSQFTFT PEEIKYDNKH YKYLKYTAYK KDNQQYQEDK
HKIRGYNEVI EKPQKYLKNN NINNGYPSKS PECKPQQLTA IGNRLLDWFS VIMADSKKRR
QHSQKSKAHF PPACKTEAKW MFGHLDLNND GFLSLQEMYD LEHDQNERCI KPFIDTCDLD
QDNSINTREW CRCFEKTDRP CAAVRRRIAG DFAGEIGAYA PDCDVQGFYK PTQCHNSVGV
CWCVDKHGVE FANTRTRGKP NCESVVNNAS SLTSDDEDEE TDDEDSAEGS GDQIMVF
//
