ID A0A0L0CSI1_LUCCU Unreviewed; 153 AA.
AC A0A0L0CSI1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Protein wntless {ECO:0000256|ARBA:ARBA00015887};
GN ORFNames=FF38_05931 {ECO:0000313|EMBL:KNC34359.1};
OS Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC Calliphoridae; Luciliinae; Lucilia.
OX NCBI_TaxID=7375 {ECO:0000313|EMBL:KNC34359.1, ECO:0000313|Proteomes:UP000037069};
RN [1] {ECO:0000313|EMBL:KNC34359.1, ECO:0000313|Proteomes:UP000037069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LS {ECO:0000313|EMBL:KNC34359.1,
RC ECO:0000313|Proteomes:UP000037069};
RC TISSUE=Full body {ECO:0000313|EMBL:KNC34359.1};
RX PubMed=26108605; DOI=10.1038/ncomms8344;
RA Anstead C.A., Korhonen P.K., Young N.D., Hall R.S., Jex A.R., Murali S.C.,
RA Hughes D.S., Lee S.F., Perry T., Stroehlein A.J., Ansell B.R.,
RA Breugelmans B., Hofmann A., Qu J., Dugan S., Lee S.L., Chao H., Dinh H.,
RA Han Y., Doddapaneni H.V., Worley K.C., Muzny D.M., Ioannidis P.,
RA Waterhouse R.M., Zdobnov E.M., James P.J., Bagnall N.H., Kotze A.C.,
RA Gibbs R.A., Richards S., Batterham P., Gasser R.B.;
RT "Lucilia cuprina genome unlocks parasitic fly biology to underpin future
RT interventions.";
RL Nat. Commun. 6:7344-7344(2015).
CC -!- FUNCTION: A segment polarity gene required for wingless (wg)-dependent
CC patterning processes, acting in both wg-sending cells and wg-target
CC cells. In non-neuronal cells wls directs wg secretion. The wls traffic
CC loop encompasses the Golgi, the cell surface, an endocytic compartment
CC and a retrograde route leading back to the Golgi, and involves
CC clathrin-mediated endocytosis and the retromer complex (a conserved
CC protein complex consisting of Vps35 and Vps26). In neuronal cells (the
CC larval motorneuron NMJ), the wg signal moves across the synapse via the
CC release of wls-containing exosome-like vesicles. Postsynaptic wls is
CC required for the trafficking of fz2 through the fz2-interacting protein
CC Grip. {ECO:0000256|ARBA:ARBA00025339}.
CC -!- SUBUNIT: Interacts with wg; in the Golgi. Interacts with Vps35, a
CC component of the retromer complex; wls stability is regulated by Vps35.
CC {ECO:0000256|ARBA:ARBA00025880}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Presynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034107}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034107}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the wntless family.
CC {ECO:0000256|ARBA:ARBA00008148}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNC34359.1}.
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DR EMBL; JRES01000080; KNC34359.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CSI1; -.
DR STRING; 7375.A0A0L0CSI1; -.
DR EnsemblMetazoa; KNC34359; KNC34359; FF38_05931.
DR EnsemblMetazoa; XM_023435834.2; XP_023291602.1; LOC111675102.
DR OMA; KWDEDIE; -.
DR Proteomes; UP000037069; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR047843; WLS-like_TM.
DR InterPro; IPR009551; Wntless.
DR PANTHER; PTHR13449; INTEGRAL MEMBRANE PROTEIN GPR177; 1.
DR PANTHER; PTHR13449:SF2; PROTEIN WNTLESS HOMOLOG; 1.
DR Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Reference proteome {ECO:0000313|Proteomes:UP000037069};
KW Synapse {ECO:0000256|ARBA:ARBA00023257};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..99
FT /note="Wntless-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF06664"
SQ SEQUENCE 153 AA; 17292 MW; C62453DE9B1DD4F5 CRC64;
MVFKVFRNIG AKRTSLPSMS QARRLHYEGL IYRFKFLMLA TLLCAALTVV GFIMGQVAEG
HWKWDEDIEI QLTSAFLTGV YGMWNIYIFA LLILYAPSHK QWPCANSNET SQSNENIVAA
AANEEIEFNN LPSDSNPSEI SSLTSFTRKV AFE
//
