ID A0A0L0CWP0_PLAFA Unreviewed; 932 AA.
AC A0A0L0CWP0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Cysteine protease {ECO:0000313|EMBL:KNC36641.1};
GN ORFNames=PFLG_01995 {ECO:0000313|EMBL:KNC36641.1};
OS Plasmodium falciparum RAJ116.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580058 {ECO:0000313|EMBL:KNC36641.1, ECO:0000313|Proteomes:UP000054566};
RN [1] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; GG664207; KNC36641.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CWP0; -.
DR SMR; A0A0L0CWP0; -.
DR EnsemblProtists; KNC36641; KNC36641; PFLG_01995.
DR OrthoDB; 240131at2759; -.
DR Proteomes; UP000054566; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF642; PRO-CATHEPSIN H; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000313|EMBL:KNC36641.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054566};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..932
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005537038"
FT DOMAIN 491..742
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 63..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 105544 MW; B7D01F39C726A87C CRC64;
MKVSFTLFFI IYIILNCDVL KCEVESSDST SFLNLISGQS SSNSDDTVSS SDSRGVVASV
SGTVDSDVSR TDSTGNVNSK NSELSETRQN SVEQNNNSNS SDNSIKIKSA FLKENVGVKI
TGPCDEGFGL VMVPHIIINV DTRNTDIQLG KKSSEINYGI KLRKKGKDEY EEKVGIDLLK
NVCETGKNFK FVAYIKGDEL IIKWKVIEEG NIPIDIKKFK IKRMSPPITS IQVFSSMSDE
KSFVLENKNY VVTNNMPEKC EALATNCFLS GNIDIEKCYQ CSLLVENDSK SDVCYNFISR
ENKEKLNEER FKVKGSTEYE ESVESELKGA IDLLISSFYK SDGENGENVL ISFEDLNSTL
EDDIINFCSL LKLVDLSGTF MNHQIGTTAD AFNNIVKLLK EHKEEDEFVL RTKLRNPALC
MKNVDDWVKS RCGLLTSDDS YVVIKKNSDT NGKNENNESN DEEYDGVIDL STNENGNVKS
IQFNDDIYCN DDYCNRWKNE NNCISKIGVE DQGNCASSWA FASKLHFETL RCMKGYDHLG
ISALYLTNCS KGKISKRCTE GGNPSEFLEI VSNSGFLPTE FDYPYFYALV ENSCPSGLNK
WINLWEDVKL FDYKYEPNSI GSKGYSVYKS EMFKDNMDEY VKMIKSEIKN KGSVIAYINA
QSVLTYDFNG KNILNMCGSK TTDHSINVIG YGHYKNKEGE EKSYWLVRNS WGYYWGDEGN
FKVDMYGPSN CNYHFINTVL VFNIDIPMMN NNENNKKGLY NYFPKYTHEF YHNFYDQNFG
SDNKISLINS NGSNKNDVNN AYTVHGQSGE TEVQPSQLRS TANQDSNRGA VTSDPLRTQP
ETTSTSVKKM DVFQVLKHVK NSKIKVGLIK YDNDDEIGAH HSCTRAYSFD PEKYDECVEF
CRKNWEQCKD KPSPGFCLTK LDESKGCFFC YV
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