ID A0A0L0CXM3_PLAFA Unreviewed; 2253 AA.
AC A0A0L0CXM3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Histone deacetylase {ECO:0000313|EMBL:KNC36951.1};
GN ORFNames=PFLG_02275 {ECO:0000313|EMBL:KNC36951.1};
OS Plasmodium falciparum RAJ116.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580058 {ECO:0000313|EMBL:KNC36951.1, ECO:0000313|Proteomes:UP000054566};
RN [1] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG664326; KNC36951.1; -; Genomic_DNA.
DR EnsemblProtists; KNC36951; KNC36951; PFLG_02275.
DR OrthoDB; 69755at2759; -.
DR Proteomes; UP000054566; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054566};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1559..1898
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 388..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 467..494
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1923..2002
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 664..704
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2253 AA; 269013 MW; D13CCC9D7E40A886 CRC64;
MDIVKDERNI RYEYELDKIK KKKKDNLLIM NILYNKINYI CYILKSNHRD ILNDINFENR
TAIEICLYYC KSYILFLLLF YPYLHNYIRI LKNNDLRLYK NFYKYILKRR NNLHILLLKY
RILECMKLKD KDVNDSNTIS YIDVYSMNRY MNDEDDIDKY YYKPKFSYKN NNMNNLLLLN
VYFKDIMSKN NFICILFSRI YIKKYHKKIF RILLLILFYF SLPTFPFSKK FFITYHNWRD
TEKDKIKEEN EENHTNTKGI NNSTYDNIYR SVLEDKVEGK LIEHNKNISK NNVGVQAVQE
GVVYGTEEIL KNENKGTGGM QGNNIKKKKD RGKKKDMDED FSFYCKRKYF TTPFFEHINI
PTIHINDYFC SGNKIFEREE FKVINEKKNK KKKDNTNKYE SNYDSKYDNN NSRDHYNNFR
TYEENNIYNS DSSSSVSSSL SDDILSDIED ENMLKELFKN ENKIYSKEES KKNDNEKERN
IKNLMKEKQN ILNEKLKDID TNYSKSTLND MKNDFFQMNI KEYDWYDDNN IIRRVYRKED
DIIDNFTLKK EPFVSELWIN VINFNVEDDN KNTLIHKACL VGNLNIIYIL LYLNVDLFIY
NYKSELPVHC TIYNCDKYIF LLLLHNTIEC IFYVLLEEYK RWNKTHNMLN TKTESEKMKI
QNRKNKLKEK KKNKKKNKNK KNKNKKNKNK KKINKSRINY NNKKKNNKKN NQNVQNVQNV
QNVQNVQNAQ NVQNVQNAQN NIDSFNSSEK HDEDIEEVNE MYKKYIKDGK FFYYKNINDK
FLYNVIQLYL SVIVKIIELG NFEFLKILFN YNSSIFSYIF LNKNMFSFLC SIACMYNCLN
VFIFYCGNII KWSVFETYVE EQKLNFLERT KKRKNVSTYG TNNNDENQYN FYDMNNEKKR
NEFQNNNLFQ TGPCSSIKKN KTNLDTSKDT SCFINSYEKI EDVHQQDFFN ILKCVPYIIN
NGRMSGIGNN MDDNNISGEN NMSRENNMSR ENNMSRENNM SSENNMSSEN NMSSENNMSS
ENNMSSENNM SSENNMSSEN NISGENNISG ENNISGENNI SGENNISGEN NISGENNMSR
ENNMSRENNM SRENNICYPN NMYNQNNMYN QNNMYNQNNM YNQNNMYYPN NMYNQNNMYN
QNNMYNPNNM YYQNNMYNQN NMYNQNNMYY PNNMCNPNYL YNDNNNNLCN NMLYHYFKIN
NMVNHRFLNI SNISFYDPHV NAILTCRAKD PIGTFLRNVI IKKIINNNSI KIFFSKECFK
HIFVPEPCDH PYERNKLKNN IPENSTRLDV LISNKHGILN INTFAKFKVK CVDRKATVND
ILRVHDVSYL KFIINKIKNF KMSDDDLMYF DDFLTKAKKN FKNYLLTNNG NENTGNQNNP
IQKNEILQTF YLINKKSELE NIMLIRMNNK FMGNRDLYIQ NYLSNIHTPM HANLKDKPLV
SLELKKILSD SDSEDNNNND IENYEPEKYV YMENGIRMNI LTDEGLTEAA NVLYINNSIL
YNNNIFFNNN LLYNNNILMS EKNTDYPFFH NEDIVGTNKS ATNLLIQEKL SSYNINVREK
KKKKNKWNKD KIEKLLLVDN DTFVNKYSFN CALSASGVVL KAVDYVHKQK KIVNCGYEKL
KKCKKCKYCK KCENCKKCKN SETCKNCKNC KKCEYCKKCK KYRIQNNSII PNNRKKIFCV
VRPPGHHLGT FGAAQFNLTD EDVAAGSQGF CILNNVAVGL AYAKYTYKKF ERIAIIDFDV
HHGNGTEQII RNLGLKKLTV NEYIDIYSWK GWKDNNDKKN IFFSSVHAYD GYFYPGTGYD
TVELEPYIIN VTLKKNMTSL EFLNIFHSKI LIHLYYFKPN LLFLSAGFDG HQLDYVNNGF
VKKNTSTYFY LTKLVLSLQN KLNFPIISVL EGGYNTSKDM ASVFSLSVLE HVLSFYYNDI
SFFRKKEIKL KDLKKNIERM ERYKNDLKKY KNDLKKYKDD LKVFEDYLKE NKNLFENYKN
DLKKHRNDFK KHKNDLKIFK DDFKKYKDDF KIYCDFNNYY DLKKSCNYFS IYYDDFNKYY
DNLNVHEHTN NNQTTLQSNT DKNNTSIETC NTNIIDKMKN KIKKSEKENK KIKETPTLYY
PFICIGKKKI INMFERYFSV FKEKTEETQN LNLFYKLVEY NNFLKIYDLR NIDMKNKMNK
FMQTHEAVLK NILLECNYDY SKIDPIILPS NCYFYELLNY LKIKGISMKP KTPTKLEKKF
FSAINNPYDF NKIDLENCKR HPKKNFEFIN FWN
//
