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Database: UniProt
Entry: A0A0L0CZX8_PLAFA
LinkDB: A0A0L0CZX8_PLAFA
Original site: A0A0L0CZX8_PLAFA 
ID   A0A0L0CZX8_PLAFA        Unreviewed;      1128 AA.
AC   A0A0L0CZX8;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Translation initiation factor if-2 {ECO:0000313|EMBL:KNC36944.1};
GN   ORFNames=PFLG_02268 {ECO:0000313|EMBL:KNC36944.1};
OS   Plasmodium falciparum RAJ116.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=580058 {ECO:0000313|EMBL:KNC36944.1, ECO:0000313|Proteomes:UP000054566};
RN   [1] {ECO:0000313|Proteomes:UP000054566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA   Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA   Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA   Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "Annotation of Plasmodium falciparum RAJ116.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000054566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA   Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA   Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA   White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT   "The genome sequence of Plasmodium falciparum RAJ116.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC       and promotes its binding to the 30S ribosomal subunits. Also involved
CC       in the hydrolysis of GTP during the formation of the 70S ribosomal
CC       complex. {ECO:0000256|ARBA:ARBA00025162}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007733}.
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DR   EMBL; GG664323; KNC36944.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L0CZX8; -.
DR   EnsemblProtists; KNC36944; KNC36944; PFLG_02268.
DR   OrthoDB; 276865at2759; -.
DR   Proteomes; UP000054566; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 1.
DR   Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43381:SF5; TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW   ECO:0000313|EMBL:KNC36944.1};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054566}.
FT   DOMAIN          210..388
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
FT   REGION          863..889
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          972..994
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          644..673
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1128 AA;  132291 MW;  AC6191D8ABE876D4 CRC64;
     MFNFCSRLLY KGKYIPVGRR IFREKLIKGR KQKSPIILLP PYITVHELRI MLNINYETCF
     KAANVYKCGN VYRWKDSEDR VFQTVNKRNV IIPYSTAAYV SKIFKYKPKL VQVELYCEQE
     NYDLEHMNLL DIYKNTYIEE KKYYDEFYLL SQNNEKKNTN ELKNINIRGF KNETKNCNIN
     NDISLLINNK YISSNIYTNN KKINDEKKKN YYTVISVIGH INHGKTTLLD KITNNNLALN
     EAGCITQNIK PIHFEYAPFK FTFLDTPGHK VFQIFRGRAA FLSDILIILI SLEVGAEIQT
     EEAIKYADKF DIPVIFVLNK ADIYGSNESI VKAELKNQCR KMYDEQILKH NFSNEIDKAI
     TISSLTGYNL HKLINRIYFL SQHMNLPYNN INNDNINSNN IDNNLAYESM KKNFLIPQNK
     DDININHLDN NDNNNNNNNI HLSKNNPTHD NSNLLKKYIR KSDFLLALDT YPFGMGIVVD
     ISKNSSKGTI LNVIIRNGFF IEGNYFICGS AYGRIQKMYK FNTNFKENCT YASVGMAIQI
     AGIRKYGNAT TDDLIFTLPQ NNAFRLCQYR LMVEKLSTLQ VSGKEISVSW ENDMKKNEYH
     AEDIYENRLE MSDKRKAIEE FGVQNEPIFN DITYEEFHKS NTQLKKEQDN YIEIQLEEEN
     ENQKSNIEKI NKIQNVLSND EYDDCIVIPH DNTYSFLKTS KNEEMHVSKH AQISSLNNTN
     EAILNDTQMC QQNEQMKEEM DSIYTDKINA NMEKEGDIIY DQEINDNKKG YKIDSQNNSE
     LSQINKKKNQ IIKDDHNSEY DNETNEAQVN TNNIYNINNE ENSTNSNSYK EYLETYNVET
     TIPRRGRKNK YSKNIYKINT KSPFKDNVTN RSNYNNDNNY NSNNNQNNDL RAPWYYEESE
     ETWAKKVLQR NDELMETWRN KTKQRELEKQ RQIFYEKQMI LKNEMIKRNL LGEEKLTEEQ
     INAYLYDEPN KNKKYDTDIN QNDQNDNDTH TDDKFNLPKK NCPVIPIIIR TNYVGIFDIF
     LDEFENLQKK YNVKISVVHG GIGPITPNDV VHAEVESHFG YCCIYAFQVK VLPDSVKQAV
     LSNIVIKQFD VFTDLIDDIV KRITNIKALI AHNMYVRSLK KEKTQEGM
//
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