ID A0A0L0CZX8_PLAFA Unreviewed; 1128 AA.
AC A0A0L0CZX8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Translation initiation factor if-2 {ECO:0000313|EMBL:KNC36944.1};
GN ORFNames=PFLG_02268 {ECO:0000313|EMBL:KNC36944.1};
OS Plasmodium falciparum RAJ116.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580058 {ECO:0000313|EMBL:KNC36944.1, ECO:0000313|Proteomes:UP000054566};
RN [1] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RAJ116 {ECO:0000313|Proteomes:UP000054566};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum RAJ116.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|ARBA:ARBA00025162}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR EMBL; GG664323; KNC36944.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0CZX8; -.
DR EnsemblProtists; KNC36944; KNC36944; PFLG_02268.
DR OrthoDB; 276865at2759; -.
DR Proteomes; UP000054566; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF5; TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:KNC36944.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000054566}.
FT DOMAIN 210..388
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 863..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 644..673
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1128 AA; 132291 MW; AC6191D8ABE876D4 CRC64;
MFNFCSRLLY KGKYIPVGRR IFREKLIKGR KQKSPIILLP PYITVHELRI MLNINYETCF
KAANVYKCGN VYRWKDSEDR VFQTVNKRNV IIPYSTAAYV SKIFKYKPKL VQVELYCEQE
NYDLEHMNLL DIYKNTYIEE KKYYDEFYLL SQNNEKKNTN ELKNINIRGF KNETKNCNIN
NDISLLINNK YISSNIYTNN KKINDEKKKN YYTVISVIGH INHGKTTLLD KITNNNLALN
EAGCITQNIK PIHFEYAPFK FTFLDTPGHK VFQIFRGRAA FLSDILIILI SLEVGAEIQT
EEAIKYADKF DIPVIFVLNK ADIYGSNESI VKAELKNQCR KMYDEQILKH NFSNEIDKAI
TISSLTGYNL HKLINRIYFL SQHMNLPYNN INNDNINSNN IDNNLAYESM KKNFLIPQNK
DDININHLDN NDNNNNNNNI HLSKNNPTHD NSNLLKKYIR KSDFLLALDT YPFGMGIVVD
ISKNSSKGTI LNVIIRNGFF IEGNYFICGS AYGRIQKMYK FNTNFKENCT YASVGMAIQI
AGIRKYGNAT TDDLIFTLPQ NNAFRLCQYR LMVEKLSTLQ VSGKEISVSW ENDMKKNEYH
AEDIYENRLE MSDKRKAIEE FGVQNEPIFN DITYEEFHKS NTQLKKEQDN YIEIQLEEEN
ENQKSNIEKI NKIQNVLSND EYDDCIVIPH DNTYSFLKTS KNEEMHVSKH AQISSLNNTN
EAILNDTQMC QQNEQMKEEM DSIYTDKINA NMEKEGDIIY DQEINDNKKG YKIDSQNNSE
LSQINKKKNQ IIKDDHNSEY DNETNEAQVN TNNIYNINNE ENSTNSNSYK EYLETYNVET
TIPRRGRKNK YSKNIYKINT KSPFKDNVTN RSNYNNDNNY NSNNNQNNDL RAPWYYEESE
ETWAKKVLQR NDELMETWRN KTKQRELEKQ RQIFYEKQMI LKNEMIKRNL LGEEKLTEEQ
INAYLYDEPN KNKKYDTDIN QNDQNDNDTH TDDKFNLPKK NCPVIPIIIR TNYVGIFDIF
LDEFENLQKK YNVKISVVHG GIGPITPNDV VHAEVESHFG YCCIYAFQVK VLPDSVKQAV
LSNIVIKQFD VFTDLIDDIV KRITNIKALI AHNMYVRSLK KEKTQEGM
//