ID A0A0L0D2Q0_THETB Unreviewed; 2382 AA.
AC A0A0L0D2Q0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=TKL protein kinase {ECO:0000313|EMBL:KNC46574.1};
GN ORFNames=AMSG_03009 {ECO:0000313|EMBL:KNC46574.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC46574.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC46574.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC46574.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. ROCO subfamily. {ECO:0000256|ARBA:ARBA00008171}.
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DR EMBL; GL349443; KNC46574.1; -; Genomic_DNA.
DR RefSeq; XP_013760351.1; XM_013904897.1.
DR STRING; 461836.A0A0L0D2Q0; -.
DR EnsemblProtists; KNC46574; KNC46574; AMSG_03009.
DR GeneID; 25562650; -.
DR eggNOG; KOG0200; Eukaryota.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR23257:SF703; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:KNC46574.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000313|EMBL:KNC46574.1};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 312..658
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 1918..1941
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 99..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1365..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1988..2012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 339
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2382 AA; 251599 MW; 7BABCDC9814BEB93 CRC64;
MDSSRPPPAQ AMANPSCSDE PLFVDVEQDA ASGAYTEFAD TPAPDAPVTP AADRFVLNRS
AETSCVAGST SSNSMGLSVS VDLDGLANLG ASDYHKALSD NDASATSTSS DSSLSLSAES
SSSSSSHLDP ASRQASGCST DSVTCGDADS VDYEYESVPQ LMVSASLISS VASGVASKPS
SSVSRSGTES QDSDDDDASI SISFSQRLTE IDDVSAENSL KAVTAPVAPD LSIASTDSSI
THALNIGISV SGRVPTSSYQ SRAQSMLGAS AWSNISSTAI SPSTKSTTSS FAETIRSAGG
KTPLEAVAWA DLTISYQLGS GGFGEVWGGT WGATSVAIKR LTLKGDGILS QLNDLVAEAS
VLASLSHPNI VQMLAICTDT ANPAIVTELM ESGDLFEALF PLKKADLRKA RKEARGKNPT
SSSSSSSSNT PSSGAPSAST HSSTKSSSCG TSQSSGTNNS SHGSSSNNSW SNSEGSTGIV
PGHLSDRSKL HILHGVCCGM EYLHRCGILH CDLKPRNILL SRAGSVVKVA DFGLALTLAS
GSVRGFAGTP RYSAPEVIMG DAPCQASDVF SFGILLYETV TQLRAFPKIS RIKNCYASLL
PPAVLAAAEA DEIDDSLPEV YDSRLFRLTL PIIIKCIQHQ PDSRPSFAEL ASSFDSLITH
LATTGEVFPS VPPLLPNADV VERPRLVRSV VRSLTARGSA PSSACDSPNI MSKAPSKTTK
KKRLLRNSAD RDVVVATNKS TSRDRLLVSS DSSHARYSSH GVVAIGGPGS GKTWLASTIA
HEPEVGAKFR DGIHWLSLSS LSSLSDLVNS LALELNIKLR AEQLQSLRAA RDAISSRLAD
KALLLVLDGL VSASQLALCH VLVDAPDSRY LATTTPDVVD KLVGSSLPEL TSIVIPELGT
SEARALFAIH SGLSASTLPD VTTTIMTKVA LNADALCRIG DVVARQCDAV WTFASDFVTE
AVREGMTPQR AAVALAVRSL HAIRYRFREL AVFPAGKLLP VAPLVVLWRS ADEPLYPVDV
ELILRMLADK GIFHLAYPSA IDPNTVAWML TPPAADLLAW REATSQQAEV AGHTRILRAY
TATLADPFSA NVLSFAEWRT GPVATDAYYR QNLVRHLLAA GQITAAVNLV VSYYWYRDVT
RAERDDDPWF CAGSDPIAQY LDDLSQVIKA LSDPAIAAIH MSSSSGSESG TPVDASLLPW
LAEADRGAAT QELSKRLAAT SDLADLTKLR ELLNLSRGSL KSLPSMVYFQ LLGRMWPVPS
PDDVSPVVMK FINDALEHKS RAEMMYVPRS GLLVAHGGGL RAAIRSHPHR IVAMVAVGNS
YAVSLCESCM CVWDVVAGTW AEHAVDRFVP TSFLDDNGCG SSASSPLVSP FPSSTSNPFA
PIDSDGSSHS HETDNGGGLK SAASAATSWS TRVLIASAGE YFAVVTPLAA RIYTLCQTPS
VDEPFDDHAS FMRAEQTEAV GAAIIMIGSV PHLVVLTNEP APAVVPQSLV DGADVGASPV
LLDNAIEYDR LVTAAAAPLA AISTSTGVIT VVDFSSNLIL FHAAVPLSDE DNGRQTAVTA
VAVSHLVLVV ATDFGIYIWS ESELHRAHGA SMLAKHATSV EVDRQGTARL DACAPTASVP
ITDVSSLYAI PESMNVVVGR ANGELVVVSA ISGRMLGALD LHSPSSVTSM TAVTYQNAEL
LVSGDADGLV CVWNVANVLT QLGASGRAAS ASSRGLAHRS EITALTAHGE MNLVITGSGD
RTINVCDTQS GAVLDILLGH DAAVVALMWS KEKVADGAML MSVDRGGSVC SWHVSRSGSQ
RLSRGKVPFA AEISTAALSN RGIMYLGYES PDAVVGYSVQ PGATRSNLSI KAVSHLRDVS
GAVLVCKHGY VAARGTAPYN ATVSMFSAKR HVLVSELSDV HFGMVTSIDI FQVVKRVLVA
TGGADQSVAV WDAVTGTSLV RVAIKLGSIT SLRLFALEHS SSLQLVLNSS GRRPSVVVLA
LRSATPSAAK GKDKGKGKGK IKGKGKGKGK GKVNGDTLED IAEATSLRLY AKRMHRLDEP
ADRLYVATEG TSIVFTISNK TSYHRMVSLA SIRAKTAAFN AEHSDSDGLS ILEWFWNDVR
KTDSARLSVA AAKVDATQLL AESRAFRIVE HAELGLYLSR EPVALRILAA NAVSLVVVSG
VVFVWVGPEV SRTLYAQAAA LARELCLDED FSGVRSRPYF LAPPQLKFVT SDAVEPFCTQ
PPYDRLWQIL AAADASDDWR SSLATHIADV LAPVDADALA RDMRGVLSIK ELVLFGNNGD
LVLEDVSQGK FHLSMLASDK AYMVSTATAL WLWLGDAAPT EIRARVVVVS RRIADAMEHS
VDAAQEAGSL LESFGCNRRL AWRDVRFAFE GREPLMMRLA LT
//
