ID A0A0L0D3L4_THETB Unreviewed; 819 AA.
AC A0A0L0D3L4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=AMSG_03320 {ECO:0000313|EMBL:KNC46889.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC46889.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC46889.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC46889.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; GL349444; KNC46889.1; -; Genomic_DNA.
DR RefSeq; XP_013760162.1; XM_013904708.1.
DR AlphaFoldDB; A0A0L0D3L4; -.
DR STRING; 461836.A0A0L0D3L4; -.
DR EnsemblProtists; KNC46889; KNC46889; AMSG_03320.
DR GeneID; 25562932; -.
DR eggNOG; KOG0474; Eukaryota.
DR OrthoDB; 1089019at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF136; H(+)/CL(-) EXCHANGE TRANSPORTER 7; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 115..139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 160..183
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 227..250
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 262..281
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 355..377
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 427..448
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 455..474
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 486..512
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 681..738
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 769..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 90250 MW; 719079638E6CEA21 CRC64;
MPARVRHKAR RAMSGTEWEH LLQRSHVHHS EQDDVQSLDY EVNENMVWRA HVASKSNWAY
SRERGLKWVV ALLVGMATAL VAYTIDMFIR GVAGAKFTLI SRLIVDCDNC FWSPFLSYIA
VNVLLVSVAA FAVAFIEPVA AGSGIPEIKC YLNGYKIPHV VRLSTLLCKA GGVMFSVAGG
LAVGREGPMI HSGAVLAAGI SQGKATSLPL DSGLFKTFRN DHMKRDFVAS GAAAGVSAAF
GSPIGGVLFS LEEGASHWNQ ALTWRTFFCT MISSFTLNLL LSGTSPGVKW GYLNQPGLVD
FGEFVAQSYT VVEIPFFVII GVVGGLSGAA FNAINTKLTL FRMRFIPVSK PWARFAEALF
IAALSATVSF LFAFFIFECR PEPTTVYEGI TLRRFTCPEG EYNDMATIFF TTQEEAIRQL
FHNRDAFSYP TLAFFMFAYF GLAVVTYGAS VPSGLFVPCI LTGCAFGRLA GHALEHLFPS
IVHDPGTYAL VGAAAFLGGV VRMTISLTVI ILESTNDISY GLPVMLTIMV SKIVGDLFNE
GLYDIHIDIK HIPFLGWEPE RLMENLTAAD IMSTPVNVLP YFVRVRDVVV LLESNTHGAF
PLCGIDENGL PSDQFVGIIL RHEIITLLKR RAFVDYANAV RSHVDWLDFV DDYPRYPDIV
DIRADIFDED MDKFMNLSPY MNPAPITTQP VAAATAVFRL FRGLGLRHMV VVDRMRRIMG
IVTRHDLVHL EDKFHRDGSP RDVPWHNPHY QFGRDTPRSH EASIAHLYGS TDSKDTSSIT
SLPRSSATPV QSVAELLASI PGSNVDPQAS PTLQRSGIQ
//