ID A0A0L0D426_THETB Unreviewed; 1509 AA.
AC A0A0L0D426;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Egg laying defective protein 19 {ECO:0000313|EMBL:KNC46856.1};
GN ORFNames=AMSG_03287 {ECO:0000313|EMBL:KNC46856.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC46856.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC46856.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC46856.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; GL349444; KNC46856.1; -; Genomic_DNA.
DR RefSeq; XP_013760129.1; XM_013904675.1.
DR STRING; 461836.A0A0L0D426; -.
DR EnsemblProtists; KNC46856; KNC46856; AMSG_03287.
DR GeneID; 25562899; -.
DR eggNOG; KOG2301; Eukaryota.
DR OMA; DPNKECA; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF62; SODIUM CHANNEL PROTEIN 60E; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 77..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1067..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1104..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1138..1157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1202..1221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1279..1306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..341
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 416..639
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 801..1028
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1070..1315
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1327..1379
FT /note="Voltage-dependent L-type calcium channel IQ-
FT associated"
FT /evidence="ECO:0000259|Pfam:PF16905"
FT REGION 1462..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 595
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1015
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1509 AA; 166956 MW; D582A43CBA10059A CRC64;
MAEVGVPLMR FGPSSSCGSS GSASLSSSAA WTEDDVELEA RVQGVTTNKV YTSRSLLLFE
LESPIRRMAI ALVDSPWFDR FILLAIVVNC VFLALWNPFD PPNSQRNVVL DIAEYVFTAI
FTAELMLKAL AMGFFMHKHA YLRDPWNWLD FGVVCLGYLT LIPGIGNYSA IRTFRVLRAL
RTLSGIPGLR VVINALLASM PPLLNVFFLL TFFMVVFAII GVQLFAGSLR QHCVDLATRS
FDPSDVNLCS LSNFGGRDCP SGFQCLATGP NPGFGLISFD NFGVALLTVL QVVTMDEWEI
VLTAVLRTTT PLAAFYFVLV ILFGALFIVN LVVAVVYSSY ATSLDILVEA DDFSSDAFDD
SHFVPLSVAG PSLAALRAPS LARLHSAESL RSGGSAGADR RLPQWRHLIN EFVQSSIFQS
IIIAAIVLNT VALSLEYPNA PRKLKDVLFW VNIVFTVLFA LEMVLKIAGM GLRRYIADRF
NVFDAFIVVV SLIELVAARG EGSGLSVLRA FRLLRVFKLA RSWSSLRTLL DVIMSSIGSI
GSITLVMVIM IFIFALTGLQ LYGGRYEDLP PDRSRTDFDD FWSAIISVFR ILIGEWTVPL
YDAIRATNES AIIYFVVVLL VGNYLILNLF LAILLSNFEW AEVNRLEEEA RAAAEERNGG
AASRTATGWR SWPRRVHRLI CGRCAEPPHD DHKVVNGTHV DAAGKPVFVV KDSSDDDAPL
ARPRSVAEHA LGSARNEPRS FSLDSIVSAV VESSQAAESE CSDDAAATDD APKYKRLYGN
ALFAFPPASK LRVVLQKVVE HPSFEWVVLV FIFLSSVALA VEEPGLDPNG STTRVLYILD
VIFAVVFTAE LVMKVLVYGF WFHYGAYMTD AWNRLDAAIV AISIVSLAGP SSLSFIRAIR
TLRAFRPLRA ITRNEGMRVV VNALFASIPA IFNVLLVCGL FWLVFAILGV QAFGSKFAYC
TNPDVEFRHQ CVGPFNATSP DGETSVELAR WTNPNINFDH VPNAFLALFQ VATFEGWYDV
FWAAIDATDI NRQPRTNNQP LMMTQYRPSI RIERPASRLR GVLYDIVMAP AFELAIMVAI
LANMAAMCLQ YYGQPSDYTL GLEIVNYIFA FIFALEAGIK IAVYKWLYFV NRWNQFDFSV
VLLSLVGIVI TLFGTVLPIN PTLLRILRVF RVARIFRIIK SAAGIRKLMI TLLYSLPSLV
NIGSLLFLIF FIYAILGMNI FGKVILQDQL NNETNFRTFP KSMLLLFRVS TASGWDVLLG
ECSVQPPDCS REAGNCGDFT LAVLFFVSFL LVTFYVMLNL FVAIILESFD IATREEGATV
TDDDLSNFAE KWSHYDPNTT YFIAFTELRA LVLELDPPLG VGAELSDADL DAEIHRLDVN
IYLADDGSWQ VNFLDVLLAL SRRVNDDVDL PESIKAKTES RLRKAFPQCR TREPMATTLQ
IGAALRIVEW YSAFKNRSRA RAAAADTAPG PDAAAGTTPA QVSSDSSSSY ESYSYSSPAA
DLASHPVVL
//
