ID A0A0L0D524_THETB Unreviewed; 1018 AA.
AC A0A0L0D524;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Potassium channel protein {ECO:0000313|EMBL:KNC47350.1};
GN ORFNames=AMSG_03784 {ECO:0000313|EMBL:KNC47350.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC47350.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC47350.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC47350.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|RuleBase:RU003857}.
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DR EMBL; GL349446; KNC47350.1; -; Genomic_DNA.
DR RefSeq; XP_013759688.1; XM_013904234.1.
DR AlphaFoldDB; A0A0L0D524; -.
DR STRING; 461836.A0A0L0D524; -.
DR EnsemblProtists; KNC47350; KNC47350; AMSG_03784.
DR GeneID; 25563357; -.
DR eggNOG; KOG1418; Eukaryota.
DR OrthoDB; 600333at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR CDD; cd00030; C2; 1.
DR Gene3D; 1.10.287.70; -; 5.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF291; POTASSIUM CHANNEL SUBFAMILY K MEMBER 18; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 5.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 5.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:KNC47350.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..74
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 325..393
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 529..597
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 664..731
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 838..883
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 241..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..975
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1018 AA; 107707 MW; 926819ED2BD3ECED CRC64;
MTLAVAIVLL SGTVTFVYVE ELTAVDAAYL TTVTVTTIGF GDIVPTTDNG KGAVGVFVLI
GVGLVGYALS TISQISGNRV KDLVAKLHSK GLSDPYVVLG PADRASSSFC ASRCRCFVYF
PCCAPGGAWF YTPVANGLST RAGLTRLSVY DWDANTVDDL IGSVLVPIPP HILHASPPDA
ERPHDAQSPY SDAYTGIGPS SAFSSAQDVP IEPLSQTPPD AWYPINVPLT LSDDAADMYL
RAPPPSASTT SSSVSSASSA LDSDTTALVP NPRLKIAIRR HGDAIEVKVL SASGLPVMDM
SMIGNALRRA LNKDLLEVIL AFAVLGVLVV GGTLAFAHIE DWRLLDAFYW AVITLFTIGY
GDITPSTKTG RIVFIPYAFL LLGFGAYALS LLMDKSLGLL TKYALVAAAS SHARCCNNSA
TPPDAWYPIN VPLTLSDDAA DMYLRAPPPS ASTTSSSVSS ASSALDSDTT ALVPNPRLKI
AIRRHGDAIE VKVLSASGLP VMDMSMIGNA LRRALNKDLL EVILAFAVLG VLVVGGTLAF
AHIEDWRLLD AFYWAVITLF TIGYGDIAPA TKTGRIVFIP YAFLLLGFGA YALSLLMDKS
LGLLTKYALV AAASKPMPDA ANNSASPADT HCWASLRHKL RACVTTRQGK FQVQLVIALA
LTVALILVGG LISLQEGWTY LAGVAFALET ASTLGLGTRV PKTDVGKILT MAFALFAVGV
LFSVISVVAQ LSVERSLVFK RELLRRKAEA HELEAQLVAQ ASGHVLAIDA PHSQPSIAAL
APGLSAESLA RPSKSRYAAT RDWVKTSFAA QVFLGLVGFF AINCAAAGGL RYTERGIITR
YRDAMYASLI VSSSTGYGDI VPKTEEGFVI IYALLLIAYT LLVWIIDVAD RATNEAVGND
VDNTLLDSSQ VIVGSALTKR ARNHLSTSSS SSSSSSSSLA SDAAGTRSRG RTPASHPNSR
GRGRGRGRGR GRGARAPRNV PRASHPAQRN AARDRPRRAP GRAPPSTRGR RPRPTGPH
//
