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Database: UniProt
Entry: A0A0L0D678_THETB
LinkDB: A0A0L0D678_THETB
Original site: A0A0L0D678_THETB 
ID   A0A0L0D678_THETB        Unreviewed;       552 AA.
AC   A0A0L0D678;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   03-JUL-2019, entry version 18.
DE   SubName: Full=Peptidase S8 and S53 domain-containing protein {ECO:0000313|EMBL:KNC47700.1};
GN   ORFNames=AMSG_03931 {ECO:0000313|EMBL:KNC47700.1};
OS   Thecamonas trahens ATCC 50062.
OC   Eukaryota; Apusozoa; Apusomonadidae; Thecamonas.
OX   NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC47700.1, ECO:0000313|Proteomes:UP000054408};
RN   [1] {ECO:0000313|EMBL:KNC47700.1, ECO:0000313|Proteomes:UP000054408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC47700.1,
RC   ECO:0000313|Proteomes:UP000054408};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA   Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA   Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T.,
RA   Howarth C., Jen D., Larson L., Mehta T., Park D., Pearson M.,
RA   Roberts A., Saif S., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   Thomson T., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA   Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA   Lander E., Nusbaum C.;
RT   "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
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DR   EMBL; GL349448; KNC47700.1; -; Genomic_DNA.
DR   RefSeq; XP_013759182.1; XM_013903728.1.
DR   EnsemblProtists; KNC47700; KNC47700; AMSG_03931.
DR   GeneID; 25563498; -.
DR   OrthoDB; 1294880at2759; -.
DR   Proteomes; UP000054408; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054408};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    552       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5005537203.
FT   DOMAIN      196    547       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    265    265       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    269    269       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    464    464       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       505    505       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       506    506       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       525    525       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       527    527       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   552 AA;  59673 MW;  7544C2C263CA1818 CRC64;
     MNKQLLCIVL VALVGAALAT RAHVERSAPV PLADGWQALA QRATADDLLE VRRVHVALWG
     NYEELDELFW RVSNPKHEDY GKYVTTDEIT AMVAPAIEVQ QAAMAFASSD GVQATLTRNR
     DMVEIKTSLA KLEELFEVEF YKFEHKTGKV VTAALGPYTV PSELAESVAF VSGLVGLPDV
     HEAKPREASA VDDGQDITPA VIRARYNVTG TASGAHNNSR AVAEFQAQWY SPRDLETFIS
     RFSPGSSDKV AKVVGSNTPN NPGVEASLDI QYIMGVVPDI PTWFYGMANF DFWSDLTAWQ
     AQLQGEDDAP WVHSISYGSQ GNYPSESYRQ RADVEYQKLG ARGISIIFAS GDSGSGNQGS
     TLYPSYPATS PHLTCIGATR FLEGNTGAEG AVQAFKSGGG FSHLFQQPSY QTSAVDAYLK
     SGVKFPSSHK FNSGNRATPD AAALGAEHYQ VIDAGRQVPV GGTSCSSPTF ASIISLINEE
     RLKAGKPTLG FLNPWIYQNP HMLWDVTVGD NDTGFDNEGY KCAEGYDAVT GLGTPNYPAM
     LQASMAVFDN LE
//
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