ID A0A0L0D6Z6_THETB Unreviewed; 1270 AA.
AC A0A0L0D6Z6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=TKL protein kinase {ECO:0000313|EMBL:KNC47985.1};
GN ORFNames=AMSG_04220 {ECO:0000313|EMBL:KNC47985.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC47985.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC47985.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC47985.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349449; KNC47985.1; -; Genomic_DNA.
DR RefSeq; XP_013759002.1; XM_013903548.1.
DR AlphaFoldDB; A0A0L0D6Z6; -.
DR STRING; 461836.A0A0L0D6Z6; -.
DR EnsemblProtists; KNC47985; KNC47985; AMSG_04220.
DR GeneID; 25563773; -.
DR eggNOG; KOG0192; Eukaryota.
DR OrthoDB; 2999496at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR PANTHER; PTHR23257:SF779; SERINE_THREONINE-PROTEIN KINASE WNK4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 2.
DR PROSITE; PS00889; CNMP_BINDING_2; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Kinase {ECO:0000313|EMBL:KNC47985.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transferase {ECO:0000313|EMBL:KNC47985.1}.
FT DOMAIN 63..349
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 416..554
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 644..870
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 897..996
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1068..1159
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 22..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1270 AA; 139314 MW; EB15E114B7F7E524 CRC64;
MSATVTYSGD AEATVTELAP PHKIMTGSDG RVGTAPSSRQ GGDGRIRFEV VCKDLAVIPF
SDLTIGPLLG QGGCGTVYKA TWQHAPVAVK FLSKAHSVSV IQQFLAEISI LSEKRHPNIV
YYIGMCPEEE HVALITEFMP GGDLATLIHS SGLYLDLSHR IQLLMDVARA LAYLHADEKP
HRDIKPANIL LSQDYSMAKL GDMGLTGAKT GKYAGFGTRL YMAPEVLLGA ESDETSDMYS
FGVVMYEVLT GRRPFHDTGY SKSKSKSKTR TRTASPTGTG TELRPRTRRR TGGPPRSRRA
NVYQMPGRIP ASLPPRLAEA LRACLDPERM RRPTANAVLE ALSAAQEMET SQLESQLEAR
LQAAAAIRLQ AAWRGRRERQ VLHARGIPVK NVQRAPGALA IPSSLPYVED HYLSGSTLRI
LDMRLDLLIS RMTQPFASDA DLVHTVLFTH PCFLPAPSLV DVLILRFSAP VAYPSPEREA
HYADAVLPKL RLQVLALLKV WILEYPSGLG EDMDAATKLF GFLTDIVAGE CGGERRRGGG
SVRPSTLDVL QRARQAALSP NASSSSLDNS GVFSGLDDDR GTGGPSEVGH AVQLAAIELL
DLLRAHQAGY LSQYTFSLHS FEVASRAPAV IGCIHKPRSL LDIHHLEVAR QLTLLQYHYY
FQIRPAELMD AAWKSRSASF RAPHVVSVLK CTEDIERLFQ SEVLSLDDAE SRAHAFCHAL
DVADACLDMA SFSVALCVVR ALTSPPIARL RQTLARVPGR YRERLARFEA LFLVKAAAEY
HSMLQHTKPP FLPALPIHLG ELSLLHDKME TVQRRRFVNV AKMEAYTATI SSILRFRTQR
FLFRPNMMVA QFLEGAPKWE PERCHAISQA LEADGASGGE VVCVEHAPRP MPFVQPLLEG
LDEPRFLARL FQVMTVEHFD DGDRIVAEGE VGESMMFINR GQVRVTFSSG AAEKVLQEGD
FFGEVALFLR VRRSASVFAV SSVELLVLSA ERANELRAEF PVMDTYFGKL SQQRMAARLG
ADVLASSSGG GGSTRETSWM SRLATKIMQE AHDVRVPPEF VRALQARLVS RRFPDGEHVI
VVGDTARSMY FVVEGAVEFE MGDGRMFLSD ERAFFGELAL FLDQPRSASV RAVGDVEALE
LTLEDTEAVM ALYPKMRRQF VQVSQLRVST GSRFRPPQWI RDVAAALRRN YLLTSAHPSS
AALAAATSAS AALVATTSAE AVSGAGPSSV AERRRQQLSR SSSGRGRSNS LSAPFLVDEQ
LSATDRMAPV
//
