ID A0A0L0D728_THETB Unreviewed; 1914 AA.
AC A0A0L0D728;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
GN ORFNames=AMSG_04138 {ECO:0000313|EMBL:KNC47906.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC47906.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC47906.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC47906.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349449; KNC47906.1; -; Genomic_DNA.
DR RefSeq; XP_013758928.1; XM_013903474.1.
DR EnsemblProtists; KNC47906; KNC47906; AMSG_04138.
DR GeneID; 25563699; -.
DR eggNOG; KOG0619; Eukaryota.
DR OrthoDB; 5369at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00030; C2; 1.
DR CDD; cd00519; Lipase_3; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR002921; Fungal_lipase-like.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01764; Lipase_3; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 426..546
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 873..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1914 AA; 202990 MW; 7A2D1C323F25C27D CRC64;
MDSDGATYLQ LVSANNAEAS VYATFATFEE AVYDALPTYT DTWEQLVVTS TKTKTLALSK
EDRKRASASP PQPWNRLPIA LSSMSDLKVL ILAHNAFSSL PPDLGLLSNL LYLDMAHNVI
DSVSASVLCS CSALQTLSLA GNKLTAFPDL SSVSSLTSLN LSGNAINAIS ASGPLIPHSL
RILDLAANGL KKISGTFLAH HGSLTSLSLA NNPKLKALPA LSFRFAVSSL RNLDLSTTAV
SWLPAPVCAR LRKLETLNLL DTAVAHLPPQ FDSLVRLHTI SALNFTLSAD SGLDVKGSLH
HFFRLCGQTA LPLFRSAFAD LLLTHEPNTY DVIRAGAAPR YLDLLRSDVS ALVESAINVL
SKLLSSEHNK AELLCAGLIE ALGPVLATAP TELVELATSG LVLFAEHGGT RLLASLSTSD
IPSVARFAAD ALSALAVQIP AAGMLQVRVL EAMQLVDPST GKSPSSAYAV LRVGTEKTTT
EARKAPDGAP AWSRNAQLNV GIADAMGRII TVKLYNRRTL RKDVFLGSAR LPVLTFLDGA
VVDNWFQLRP PDSRVSSEAA LTGYVHMQIQ FTSQASSYFE NMAQNARRLA SSEAAPSPSP
LPAPALPIIV VNGTPGSAPS PALDAPAIHP EPATYSSMLD ALDGDARLYE ILTLGLDASC
AVYFDSDTDA FLHREAFTKV QYTNRHSEQK YFYATRRRPE ATAVDLYVSF MGTYSLADAA
IDFNVLAHDA LNGRIHAGFA QRAYAIPLLP LLEFLRPPST TAAARRGALV LCGHSLGGAV
AVIVFLRLIV ECSITPDELR RIHVVTVGQP LVGDTALAAY VHALGVHTRI HAIVNHGDSV
ACFSSASPRI IAQNLIRHAK DATVAKLRQL AQERAASSPS ADEPPSPAAA SESDALNALM
TSPSSVAVDV LTHYIAARST DVFFDFTPFG ISYMIEHPAA HEGTARYDGA DFTVTVASDP
AVVKRWLDMP PEGLSTYNLD QHKLYYYFQN WEGLGPPPSA TPDLLSFPLH SLASYSERYG
GFGDDGLALS VETRDEPVSY AEVSDVVDVS NSADLAVDLA SELVSDLGTP SPSPGPRPTS
DTASGGGAGA GSGSEPSGSA PLIHLTTSWA PVISSSHAVF DSRTASIEVI LFGRSLLFVS
RLKFRGDDFD YEPVFLTDTE LRFRLRWLPA VYGKEETAAT SDGSGLSASE SGGRSAEVAA
SMGDKASTRP GSSSEAAAAA SLEAAVKLGS YESLTLRVIS HFGESRVKLN LAQHAKSMSR
VARVARKFWV EEQRRAARAS KLMAALPPAA RASLPSHWTN PGAVFAISWQ GLTNALASVA
STIEHTDLVE SLASAYLTSS AFQEYLAESG DVQLQFSHFA VRSISFPAPR VAMDALHNKV
GVALAGIAIE LEAAFSVVRL TQFLSYTNVG VTVSISDVGG SLELNVVETA DDVLSRAAEA
DDGSDDGELL TEDLVAVMAP PASFALRIGK LDVDFGLELT DDKGEVLASK DNWGFSGFVL
SQFSGYIKSS ISKALDSVPI EAALISELTR VFLEGKPGTH IPLAGSASVL TADYSLVRAP
PLKREAASSM LCTGHRGLVR TYGPNVPPEH YADIPPPRPM DAALSMSNLH DAVVALSPAM
VTSVLLAGWH AGFFALDVAA SDLPDSLADP ELFAHYASDA PPDTPFHLAV AVTSPPSVVF
DSDHGICLCL HADFTLLSGD GDGTAHEPVH TEPFVIDVSL DPTALALGDD GLAGASIEIR
PSDGVAEFDA GLGPVAAVVR QFRTEIHDFL VLAYSSRLLS LVVDWLRASP LLLLDSVKRV
VAQSQAEVAL FPDALVISFV VPEYVLDERE VAAVVATTRD LLGWGTSFPL LNATASRKGN
DSGDDAASPS PPRDDFAMDS FLNRFGAWLE RHVLVHRHGD GGGLPQGSLS QPVS
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