ID A0A0L0D736_THETB Unreviewed; 800 AA.
AC A0A0L0D736;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Cell division control protein {ECO:0000313|EMBL:KNC48159.1};
GN ORFNames=AMSG_04388 {ECO:0000313|EMBL:KNC48159.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC48159.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC48159.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC48159.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349450; KNC48159.1; -; Genomic_DNA.
DR RefSeq; XP_013758729.1; XM_013903275.1.
DR AlphaFoldDB; A0A0L0D736; -.
DR STRING; 461836.A0A0L0D736; -.
DR EnsemblProtists; KNC48159; KNC48159; AMSG_04388.
DR GeneID; 25563933; -.
DR eggNOG; KOG3417; Eukaryota.
DR OMA; NGAMEVM; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000313|EMBL:KNC48159.1};
KW Cell division {ECO:0000313|EMBL:KNC48159.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT DOMAIN 366..497
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 551..789
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 216..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 10..68
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 172..199
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 227..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 85467 MW; AE1A34AA8B4DFD94 CRC64;
MKRDALAVTA AELTADAGVL RAKLDALREA RAQLCSARTE NVLLRQSRDK LARQVQLAKA
QLRDAAADAG TPDAAAESLE LRRQHRVHLA TSFQLTEAIA AVKTDAAAAD DTAAALQAEL
AEAIASHTKH TMTVRRLKRA TSGLQARKYA LQSEVIAGVG EKNELILTLE ELAAAAADLH
NAEEDHDALR AECVAELARN RELDAAVGAK LAARNAAAAD SPSPLSPLAS APETSQPVPP
QQAKRRSFVG PEIEAKLREL IAPEPVPLAD GPAPRPHPDV TKVSAQSLFD AAAAVAASET
SEAPLHRMLW DGGVEELTGA SSMSSESPET SHAAVTANSL SAGSAHGVCS ASSGSGSSSN
ALSASLEQRI KHATVPQLVE MMTHPRHAYL DLVQAFLLTF REFCSPLEFL ELLIMRFCVT
PPLRSDAARF TTRVLTPIRL RVFNLLKMWL TRFPADFGHV AAPELTAMLN DFVTRVMPAT
GMEVASRKLA DLLDAAVATE ASASITSIRV AEDSCPAVRG ALAALAAPDA GVRTEADGSD
VIDLGAAPKK RIRELAYALS MMEEVLFRSI PETEFVNLAW SSADKERRAP HLLRMIRFSG
RVTRGVQFLV LRAAGVRARA KALRKAILLL DALMGVNNFN GAMEVMAALN SAALRSRSLK
RVWAKLPSSA TSLFDDHAAT LSHQGSYKEL RSALAAADPP LIPFVGMFLT DLTFIAGSRS
PLPPPAAGID AHVNMAKWYK YAKSIGLITR LQAMGYSSDR SAKLPSERAV WEWAAAISHT
DRTLSTDTEL FALADARADA
//
