ID A0A0L0D7F3_THETB Unreviewed; 1716 AA.
AC A0A0L0D7F3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=TKL protein kinase {ECO:0000313|EMBL:KNC47228.1};
DE Flags: Fragment;
GN ORFNames=AMSG_03656 {ECO:0000313|EMBL:KNC47228.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC47228.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC47228.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC47228.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349445; KNC47228.1; -; Genomic_DNA.
DR RefSeq; XP_013759997.1; XM_013904543.1.
DR STRING; 461836.A0A0L0D7F3; -.
DR EnsemblProtists; KNC47228; KNC47228; AMSG_03656.
DR GeneID; 25563241; -.
DR eggNOG; KOG0192; Eukaryota.
DR OrthoDB; 5482673at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 3.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:KNC47228.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transferase {ECO:0000313|EMBL:KNC47228.1}.
FT DOMAIN 817..1129
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1455..1708
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 30..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1303..1333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 844
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KNC47228.1"
SQ SEQUENCE 1716 AA; 181269 MW; EAD4120E898BD782 CRC64;
RLIRSTWQPH FQGAAIPDAL AELHATARGE PPLGLVRDNN ANRRQPFSPD EPRRVSIVVS
ASRRVLLDAC KGLADTHVAP PPPPPSSSTS GGGDGGGADT LATDAARRSE VLCAETGTHG
TDWTRISYMP IAVSYIVPMV NVPGFMPGLV LDAELVAALW HGSITRWDDP RIAAVNPGLA
LPDHHVVLIR AILPFVEDLV VRDMLSVMEE RGTYNASLFS NLPPNQVPFG TSTNVMYISN
SNEPTNAWLA LLAATRAIPR TPYSFTIVTS EAFVATGVSR DLFVATMIDG TGGHVQVSEQ
SVEVAASTLA SPNVNVLLAP LPRAWPLTHG EWLAIPTLAT KVPRETCELM RQTANGIRRA
LSSLIVSERA WLYGTRVVPS MARSALDREI YLANCNGEYI ADGSSELIVG SGSPLAASAL
EQSVEVYNAM FGSRVEFSRS SSLDGLDELV TRRAVFASTE LPPLENHLTA RPGLAAVPFA
AAAVVLPYVI PFRTGAPTTL TRLVLSRHVV ADIYLGRVTQ WADSQIVALN PELAPWLPNS
TICIHVLTPA AAEMSGETRI LLDALASFSS DAAALAQLAQ AGDWPVPCLV EHSTMGALVY
EFAFETSGLG YASGHMASAL SLRFASLINA AGDVVDATPL TVRAAAANAV NVPATNALLP
LVKTLVDQPV PLAWPLVGYT YWVFECSSTA VCAKRRAAFD YLRWALASSD TRALLRSLFF
APLTNATLTA VAANLATCTC GALPLSQVCI GPGCGASDEP VLSTGALAAA ITVPLVVICV
CALVAGIVLW SSRKHERVTV PASALPSHSI IIPSHELRIG NVIGTGSFGT VFEAQWRGSP
VVVKRVREGQ SGAGPRLSDL EFVAELMSLA MLRHPNIVMF MGADVEARGI VTEFLPRGSL
HAILHNAEFN LPQSLLGWWM HCIALGVDFL HQAGAIHSDL KSPNILLDAG WVPKLADVGI
PRIKAAAYGA HRPIAVLADG ANTSRSPLHS RLSEVSMSEQ GSIMPSPSDA SFLDANAAKM
PAVAGDNLSS LLWVAPEVVV DGEAGLSPAA DVYAFGITMW EMLTRTEPYK GTHPVVAAND
VAAAVRRPLL GLVPEWGEAY VPLMTAAWEH EPEERPSFSR LAAQLRGLYS RSSVVLPTTI
ARPEGHVVAA LISVTENAQA VTAALEETHA ALTTFHRTIG HLLQNAPEIQ GRVADWTLTH
VLVVFPLPCH FVAFTSKFLA ALSGTRVEAR VVAADGRIET LNRSLSRPFS GTYLAFRGPV
VDELVSTTAP SAASGVFVAP GLGDAVEATL CALTASAQQF PNFSSDSMGE GTDGGTGSTR
GSGSYTLSAS RRGSGVSRRP RANRELPVSN LKFRKLLDVA TPRVSRVSGE LPRANGGGAE
ALGYWGVVSL VSEASPRIAS GQRQDREAKI DSARGRGCAR AETTKHMFAN QTLSLPELGC
GSPILIALPE MIRVLAHATE VGMGSFARIC ISDIDGQAVL VKLLSEQDLG PQDVVELVAA
MASVFRMSHQ SEKDLVVHPL AICPFKPCLG IIYPLVEHGS LAAAVDAGRV GGAFARRVAV
ALAETLASLH ADNFVHGSVK PSNVMLYDSG GSRVTLTDAG LSALRGTLSV LSSTSSIIYS
SPEVLAGSSA DTSATDVFSY ASTVYEVVTG QRAFTGESPL DVAQKIMAGN VPYGGCGPRL
GAVLGRAWAP LAADRPTMAE VKDLIAALPE DEFCRV
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