ID A0A0L0D885_THETB Unreviewed; 1273 AA.
AC A0A0L0D885;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Multidrug resistance-associated protein Mrp2 {ECO:0000313|EMBL:KNC48450.1};
GN ORFNames=AMSG_04896 {ECO:0000313|EMBL:KNC48450.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC48450.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC48450.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC48450.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL349451; KNC48450.1; -; Genomic_DNA.
DR RefSeq; XP_013758563.1; XM_013903109.1.
DR AlphaFoldDB; A0A0L0D885; -.
DR STRING; 461836.A0A0L0D885; -.
DR EnsemblProtists; KNC48450; KNC48450; AMSG_04896.
DR GeneID; 25564413; -.
DR eggNOG; KOG0054; Eukaryota.
DR OMA; WTHAASE; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 142..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 732..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 778..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 849..870
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..895
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 961..983
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 989..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 146..415
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 457..686
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 741..1011
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1020..1270
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 34..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1273 AA; 133989 MW; AE342E097C11E660 CRC64;
MIDIPGIYIG AKPLPCRGWS GRRGRGDGYA AVPLGDSSDV EASEDGGPGV ASASSASPDA
SLAGYAPNPE MGAGIVSRMF FTYVNAMLAT GYLRPLGLAD MYQLMPVDDP TVAFRKLRRG
WLARGSESVI WALARGWGWL HLVNWIFLAI ATAAELAGPL FIHAILRCLA SSATCGSSVW
IYVVALSATQ ILRVLANARF SYFMKRYCTA AKSALQVDVF DSLLGLTAAG CDELGKGKII
NLVGVDAGTI RESLSSVHLA VITPVQLALG FYLLFSFLGV SVLAGLASLV ALLPLNLMLA
RGLKQVEKRV MVAKDARNKA IADMLGGIRV VKLLGWETFF SRKIGALRAT EQAAIQRRGV
LLGLGRLLNA IIPSLVSGVT FAVYVARGNV MTPAATFASL SLFSILQGPL DSVARELLAA
YATGKVAASR LSNFAGAPQR HLPPLAADPL APREQPLALC GTYAWASDDP SPVLYDLDLV
FPPNSLTLLM GPVGCGKSAI LLALLGELEV LSPGSPQFPA GSPRPAIAYA PQRPWLLSAS
LRANIVLDAE FDAPRYAAAL TAAGLEHDLT LLPAGDATEI GEKGVNISGG QKQRVALARV
LYSRAPIVLL DDPLSAVDPE QAATIFEAAI RPLAERAVVV VATHSLAFEQ IPGLRIYHVA
AGRAELASPR TLAAQESSNE PAALPAGTLP DDNRERAPHD AAAVAAGAKL KVKEDRASGS
VVAKDYLQYA RALGWTAVGT IALGLVAMEA LDVGRNMWLS KWTHAASERG GADNSKYLGG
YFGLIVASGV ATALTATLVF TASAVAGTKY HAAALVGVTA SPLTFFDATP LGRILNRFSK
DVADMDSGVL PVLVRVIMTL LKAGAVVCVI GAATPWFLLA VPFIALTYYP VSVVYQRSKR
ELQRTGSIVT SPLIAHVAGV IEGLASVRAY GLEESFADKH TRNVEATARV WNGKVNTNRW
LLLRLSLLGG GVVSLSGCLA VSAASQGTIT AATAGLALLY ASQLTGALIQ LCAAVTRVEV
RMNAVERLGH YFDLPSEARA VGGPQNGTAA ARWRVVDARA KVGICGASGA GKSSLLAALF
QTVPLAGGSI RIDGDDIREV GLVALRRSLA IIPQDAQLFL GTLAFNMDPT GTTRPEAMWQ
ALEAVGMAEV LRDKAYELDA DADPLDLELK NNLSCGEAQL VCMARALVRD ARIIVIDEGT
ASVDAESDAR IQHVIRTAFA DRTVLTIAHR LATLADYDRL LVMVDGEVAE YDTPAALLAA
EDSIYGRLVA AQT
//
