ID   A0A0L0DBI6_THETB        Unreviewed;       756 AA.
AC   A0A0L0DBI6;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=AMSG_05623 {ECO:0000313|EMBL:KNC49585.1};
OS   Thecamonas trahens ATCC 50062.
OC   Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX   NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC49585.1, ECO:0000313|Proteomes:UP000054408};
RN   [1] {ECO:0000313|EMBL:KNC49585.1, ECO:0000313|Proteomes:UP000054408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC49585.1,
RC   ECO:0000313|Proteomes:UP000054408};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA   Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA   Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA   Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA   Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA   Ruiz-Trillo I., Lander E., Nusbaum C.;
RT   "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GL349456; KNC49585.1; -; Genomic_DNA.
DR   RefSeq; XP_013757693.1; XM_013902239.1.
DR   AlphaFoldDB; A0A0L0DBI6; -.
DR   STRING; 461836.A0A0L0DBI6; -.
DR   EnsemblProtists; KNC49585; KNC49585; AMSG_05623.
DR   GeneID; 25564993; -.
DR   eggNOG; KOG0922; Eukaryota.
DR   OMA; KVKVWRH; -.
DR   OrthoDB; 3682876at2759; -.
DR   Proteomes; UP000054408; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT   DOMAIN          93..257
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          282..457
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..48
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   756 AA;  81314 MW;  6911C504F6534444 CRC64;
     MAGATAGRQG SGAKGGSDEK RQRQGKGSRK GKGGYKGKGG RKGKGRRKNP QAASAVYMDP
     ASEAEAAQLA ATAEELRTVR RSLPIFSGRK KLIKALRATQ VAVVVGETGS GKSTQLPQYL
     FEAGMVNARS RVAITQPRVV AATSVAARVA AEVGTRVGDV VGYRVRFEHR CSAGTVIKFL
     TDGMMLREAI ADDALSEYGV IVLDEAHERT VHTDVLLGLL KSLLQRRPEL KLVIMSATLD
     ASAFASFFDS APVLYVTGRT YPVQTFYAAE PLEDYIDGAL TTVLQVHEDL AEAPGDMLVF
     LTGQAEIEAL QTLLEERAPL LDASTTLKME VLPLYAALHP DEQAKVFLPP HDGVRKVVLS
     TNIAETSITI NGITTVIDCG LVKTRAFNPR IGVETLMIME TSQAQARQRA GRAGREQPGR
     AFRLYPESAF SDLPAQPVPE IRRANLASVI LLLKAVGVDD VLNFDYMEPP SIESLTAALE
     QLYLLGALES DGRLSALGVQ MSRFPLEPRF SKMLLASAEH ENTAEIITVL AMLSVESIFF
     YPKDKMGAVG AVLRRYSAGG GDHVMLLNVY KVYVMSGRSA KWCTENYVTA RSMRKVDAVR
     KQLVQLARGQ GLDPTASSDD SEALKKALLA GAFMDVALLQ PDGSYKTAKS SRAVLIHPSS
     VLFRAKKAQA LLYNELLLTS RQFMRTVTRI NPKWLPEIAP GMYAYDVASG SSAATGGSRG
     QASGSATKSL AQLKAETAAK KAALSTALAE MRTGEP
//