ID   A0A0L0DC10_THETB        Unreviewed;       630 AA.
AC   A0A0L0DC10;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN   ORFNames=AMSG_06181 {ECO:0000313|EMBL:KNC49884.1};
OS   Thecamonas trahens ATCC 50062.
OC   Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX   NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC49884.1, ECO:0000313|Proteomes:UP000054408};
RN   [1] {ECO:0000313|EMBL:KNC49884.1, ECO:0000313|Proteomes:UP000054408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC49884.1,
RC   ECO:0000313|Proteomes:UP000054408};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA   Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA   Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA   Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA   Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA   Ruiz-Trillo I., Lander E., Nusbaum C.;
RT   "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000256|ARBA:ARBA00007878}.
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DR   EMBL; GL349458; KNC49884.1; -; Genomic_DNA.
DR   RefSeq; XP_013757366.1; XM_013901912.1.
DR   AlphaFoldDB; A0A0L0DC10; -.
DR   STRING; 461836.A0A0L0DC10; -.
DR   EnsemblProtists; KNC49884; KNC49884; AMSG_06181.
DR   GeneID; 25565407; -.
DR   eggNOG; KOG1461; Eukaryota.
DR   OMA; LAQSCKI; -.
DR   OrthoDB; 5474157at2759; -.
DR   Proteomes; UP000054408; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   CDD; cd11558; W2_eIF2B_epsilon; 1.
DR   Gene3D; 1.25.40.180; -; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   InterPro; IPR003307; W2_domain.
DR   InterPro; IPR044123; W2_eIF2B_epsilon.
DR   PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   Pfam; PF02020; W2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Initiation factor {ECO:0000313|EMBL:KNC49884.1};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT   DOMAIN          456..624
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          439..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   630 AA;  68557 MW;  055C2EB04B0B17F2 CRC64;
     MEPAGRQELI SAHLDGSKWT KASSKVTVTT IINTQCITIG DALRDMDSRD VISGDFVLVA
     GDVVSNLDLR PVIAEHKRRR EADKGAIMTS VYKKVAPSHR TRSLNDDVIV GLNTETSEVV
     YFSSEVESSK IDLDVRLFTE VPKLELRHDL LDTFIDICAP EVLMLFSDNF DYSDLRSDFV
     RGILGAEILG NKVFAHIVSS HYAARIQCLK TYAAVSLDVV HRWTFPLVPD SNFMNSSLYR
     HARHNVYREQ GVTLARSSVV GGDTVIGRGT CIAEGASVEG CIIGRNCVIG KGVKLVGCYI
     WDSVTIEADV TVESSIIASG AVLRAGAVVS PGSIVSYNVV IGAGHVVPPS TKITTAAPSS
     SFDDASSFAS DSGELASSPL ASSPHAAAFL ARSSPSRASA VPSSLHADVG AGGVGRVYDD
     PCQDSSLVLR RHIATVHDLD DESDSESTAS DDSLDDGNYD PHSHFMREMV ATMDRGATEN
     HEVENVAVEI ASLKLAFDRT VADVSTAILV WLLGAVDAKD PINSTKAMLG KWSPLLRKFQ
     GDLSRDDETD LCISFQDYAM AHPEFMAVSH IPLQLLYEDD ILSRNAILAW ADLVKEEGDD
     VAILDHADRF LTWLRENNDE YEYDSYEEYE
//