ID A0A0L0DDH9_THETB Unreviewed; 1109 AA.
AC A0A0L0DDH9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Ras guanine nucleotide exchange factor A {ECO:0000313|EMBL:KNC50275.1};
GN ORFNames=AMSG_06434 {ECO:0000313|EMBL:KNC50275.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC50275.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC50275.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC50275.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349460; KNC50275.1; -; Genomic_DNA.
DR RefSeq; XP_013757102.1; XM_013901648.1.
DR AlphaFoldDB; A0A0L0DDH9; -.
DR STRING; 461836.A0A0L0DDH9; -.
DR EnsemblProtists; KNC50275; KNC50275; AMSG_06434.
DR GeneID; 25565591; -.
DR eggNOG; KOG0509; Eukaryota.
DR eggNOG; KOG3417; Eukaryota.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd04371; DEP; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT DOMAIN 268..406
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 422..498
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 533..763
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REPEAT 1024..1056
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1057..1089
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 850..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1109 AA; 118732 MW; 4C29F982D3259B50 CRC64;
MDPKLSSWLA SLAPTQAPTP PPPVGLATHT AAAAVAPVPA TTAPAADTDA GDAEPALAQA
GILELPGASG GPGSSVTSTP RTLDALSSCD SITEDELSEY VGKRASFHRF PPLLDGIDPR
DTFCAKLHIG SPDGSFTPIV RSGAVLELQL ELLPARDHVW LRGSAADASG GDVLFVTDVS
APVPADEATP PRDSSWLLFK AAPALGDAAQ VAGGTGILAG PGPTVYGLEF ESAIDATSSQ
TVLAEERAKL QKAAYFDDHE CDDLIIDDAG APRLASLDKL LDRLTFSRAD RSALDDAEFS
KFFLLTYRSF TSPVDLLAAL FARFNLPLPA VLGGDSSALA EWQTTIRDNV RARVVKVLAR
WIGLGVRDFL DDPILECMLA YFLSVVSEAG FGDKVAEMQA QYQAGVADET LNMHLLDIVR
LLETNVEQRE AKWRMKSVGL CFQGQDAVDY LFHAGVCASR ENAVAVGAQI LSAGFITHVS
GDANIPFDDN FQLFRFNLEV VESAARGMGS GSGNRPTPEL PRDLNSFEVD DLPIVEFARQ
ETLLEYALYS KIQPKELLGL AWSKKGKEEL APNVLGLIRR FNAMSLWVVT EITRRFQLKD
RVKAVKYFVA LAAKFRDMGN LNALQAVMSG FSNNSVKRLK FTWAKLDRKS NETLTELREL
LDFKGSYRNL RNYLKHVVPP CIPFIGMYLT DLTFIHEGNP DVLDGLINFE KHSKVASIIH
EMLTYQAIPF ALETVPQIKL WLSHLDGADD DTTYDWSLDI EPREAHAAGS ISKDDTTRFK
SLGRRPRVFA STADSLARAS KSVSAVHKAS RARSAENLLE LTADDPGLAR LTARINHVRA
GIDLSVATTA GRSGDADAPA LSAPGSDVLD ARSRTGSLSM DISGSSRSKR RRSRMPSQLL
SASPTTPTTL TAASAPDSML PSAASPIERL RSQSASARVR SNSLGVRLTD AGTGASPPGP
PTAPPAAAAP TAPASAAAAP KSGKLPITQL IEAALDRDGR PGTPVRKVKD LLDAGVDIDD
VNARGNSALH YVVIDSRLDV AKYLIARGAS VDIPNLQGVT PLHIATLRNN LPMVKLLIMA
GADPDETNAA GQNARDMTTN PEILELLDL
//
