ID A0A0L0DFF1_THETB Unreviewed; 754 AA.
AC A0A0L0DFF1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=RNA 3'-terminal-phosphate cyclase (ATP) {ECO:0000256|ARBA:ARBA00012725};
DE EC=6.5.1.4 {ECO:0000256|ARBA:ARBA00012725};
GN ORFNames=AMSG_12041 {ECO:0000313|EMBL:KNC50876.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC50876.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC50876.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC50876.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-
CC cyclophospho-ribonucleotide-RNA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23976, Rhea:RHEA-COMP:10463, Rhea:RHEA-COMP:10464,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83062,
CC ChEBI:CHEBI:83064, ChEBI:CHEBI:456215; EC=6.5.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00024481};
CC -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00009206}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL349463; KNC50876.1; -; Genomic_DNA.
DR RefSeq; XP_013756669.1; XM_013901215.1.
DR AlphaFoldDB; A0A0L0DFF1; -.
DR STRING; 461836.A0A0L0DFF1; -.
DR EnsemblProtists; KNC50876; KNC50876; AMSG_12041.
DR GeneID; 25569956; -.
DR eggNOG; KOG3980; Eukaryota.
DR OrthoDB; 315241at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003963; F:RNA-3'-phosphate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 3.65.10.20; RNA 3'-terminal phosphate cyclase domain; 1.
DR Gene3D; 3.30.360.20; RNA 3'-terminal phosphate cyclase, insert domain; 1.
DR InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR InterPro; IPR000228; RNA3'_term_phos_cyc.
DR InterPro; IPR017770; RNA3'_term_phos_cyc_type_1.
DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR InterPro; IPR036553; RPTC_insert.
DR NCBIfam; TIGR03399; RNA_3prim_cycl; 1.
DR PANTHER; PTHR11096; RNA 3' TERMINAL PHOSPHATE CYCLASE; 1.
DR PANTHER; PTHR11096:SF0; RNA 3'-TERMINAL PHOSPHATE CYCLASE; 1.
DR Pfam; PF01137; RTC; 1.
DR Pfam; PF05189; RTC_insert; 1.
DR SUPFAM; SSF55205; EPT/RTPC-like; 1.
DR SUPFAM; SSF52913; RNA 3'-terminal phosphate cyclase, RPTC, insert domain; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT DOMAIN 384..726
FT /note="RNA 3'-terminal phosphate cyclase"
FT /evidence="ECO:0000259|Pfam:PF01137"
FT DOMAIN 561..673
FT /note="RNA 3'-terminal phosphate cyclase insert"
FT /evidence="ECO:0000259|Pfam:PF05189"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 78644 MW; 3AEAC805CC212211 CRC64;
MTAKGVRWTG RGDRPGSSRA IASPPPIYIG TLALNTTDEW SRVKVERIDN DHVMMIAGGN
VLAVREDDLL AHKIFALPPG VTSPVGYYFD TGYLILTPAP NKVVYYTCAL PFSYSGQMCS
LVPYRTLALT NVSITTDWVD MAYGESNETY VRYGYLLAAD GTVVEIKNID EPDNAGVTKT
FTLASLVPSV VAKYPHVLSV VGMADFDNIA REYVWFTLTG SDPTTHLHLR PPGVVLAFAI
STGSIVSTAF SLPTPMGIVH YAESLALTHY GGAITTELIA YGSSAASQSI TASWAASGRT
ASACAINAGT FTNDNMIFVV SEHGSGLELV HIDANTAGYR GGSRGGRRNG GGAPTAASFP
TASFIGALDA PADRPFVAID GSLMEGGGQI LRNSFACATL LGKPIHVSSI RAGRSVPGLR
AQHLVGINLV AKMCGAELAG NGLKSVEVKF LPPAAGVGRV ASGSYDGNIP SAGSTTLLAQ
VSLPVLLFAP GPTTLNMTGG TNASHAPQID YTLQVLFPTL ARMGIDDLDL TIARRGFYPK
GCGKVVLEVS PVEAIRPIVA LDRGIVTSVD VFAFTAGRVP ASVGPRMADA AGKMLAWWFG
SAGVGVAEGD ADVVLNVETP HIDEPLAFGN GTGILLVAHT STGERLAGSA LGAKGTPAED
VGRQAAQMLI TQLEAGGCTD EYLTDQLIIY MALADGESRI RCGPLSLHTQ TAIHFVSLLT
GATFDVTPDT DPSIAGHSTN VITCQGIGFR APPL
//
