ID A0A0L0DHL0_THETB Unreviewed; 823 AA.
AC A0A0L0DHL0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Calcium-activated outward-rectifying potassium ion channel {ECO:0000313|EMBL:KNC51802.1};
GN ORFNames=AMSG_07878 {ECO:0000313|EMBL:KNC51802.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC51802.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC51802.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC51802.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|RuleBase:RU003857}.
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DR EMBL; GL349470; KNC51802.1; -; Genomic_DNA.
DR RefSeq; XP_013755670.1; XM_013900216.1.
DR AlphaFoldDB; A0A0L0DHL0; -.
DR STRING; 461836.A0A0L0DHL0; -.
DR EnsemblProtists; KNC51802; KNC51802; AMSG_07878.
DR GeneID; 25566706; -.
DR eggNOG; KOG1418; Eukaryota.
DR eggNOG; KOG4404; Eukaryota.
DR OrthoDB; 600333at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF291; POTASSIUM CHANNEL SUBFAMILY K MEMBER 18; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF07885; Ion_trans_2; 4.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50004; C2; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 45..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..260
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 552..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 88557 MW; 558CCA40FCA07047 CRC64;
MAWYQNYGAA KALMQGGHKS RQQSRLGGVS SFSCSYSSAY DEYRIIFVVT LVAVVVIAAA
LVANFEDLST LDAIYFTWAT LTTVGYGDIF PTSAGGQATV VFVGMLGLAI LSLLITIIAD
ASARRVNNVV ARLAEAGTAD PYVQLRNEPV ACAGRNGCAM PGGPCCLPRF EWCSPCARHA
YKTPVVPRSL HPLWNQVWVV DTDALAVQQH EAAPAFDDAG LILEFEVLDY DVANADDRIG
FAFLAVADVA PEWRDFEARI VLDDDIEPLT TGPPTLHLSA RCLPGTSCIE VVVIGAVNLP
VMDDYAGRQL LSSLVSNALE PTMAVLFSAA SVLIGGAIFS FIEDWRYFDG IYWAFVTVNA
VGFGDFAPTK DNSRLLFIPF TVLGLAARGY AIGVVSNAIL TRTAASYVTS ADALHGKLTQ
DDIDAANNRA ASRPCCACWY GPSGIFFRHM MAAVAVLAVS VLLGSLIYLN EPEWTWGDGV
YFCFITLSQV GYGDFVPTND GTKGFVIVYS VLGTFIVSIT IAIISKSKVD EAQFELQEKR
DARIRDFERS LKVADSEAPP DSTYDEQHES YSDSGSRSPC LSSASGFTPT SESGEAGESG
SSAAAPRFKS SKAAAGAIAA IRAIQRAEDE EKAAVRAVWR RKVARLATKV LVMTLAFVIL
NLVGAAIFME LQDPPIQQSG EYGTAVYFSV VTLSTIGYGE IVPNSTPSKI FVCLYIMVGL
AFFATLLGVL DDTTAEIFQS PADKSSYSSF TSDSGADGVF RRQFRSHKGH QVLPLWRGPR
YGEHNETRLR RAGALVPAAA SDEDSGIEAY YTYDSVSDSS ISS
//
