ID A0A0L0DK24_THETB Unreviewed; 1211 AA.
AC A0A0L0DK24;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Ras guanine nucleotide exchange factor A {ECO:0000313|EMBL:KNC51693.1};
GN ORFNames=AMSG_07757 {ECO:0000313|EMBL:KNC51693.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC51693.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC51693.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC51693.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349469; KNC51693.1; -; Genomic_DNA.
DR RefSeq; XP_013755822.1; XM_013900368.1.
DR AlphaFoldDB; A0A0L0DK24; -.
DR STRING; 461836.A0A0L0DK24; -.
DR EnsemblProtists; KNC51693; KNC51693; AMSG_07757.
DR GeneID; 25566606; -.
DR eggNOG; KOG3417; Eukaryota.
DR OrthoDB; 5473909at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 189..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 727..874
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 931..1183
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 32..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 578..640
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 33..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 132138 MW; DC56E3E67D9751B5 CRC64;
MAHLPTTPRS PDYSYATEEL LLPYHIPPLE DCRQLDSTSS TLASEPDSEP IDTRKLSDLA
RLARGSGESK PALDSAVDRP LPGPDGLARR DDNFAHPSSF DGFGSRVTAN STTTASQRSG
AIASGRRTVS FRDRNQDKLG TGTGSGANTR SDLVSSAAAG SDGRAPAQDE QIEPLTWTGQ
LERIIDSTWF AVVIGFITLF VLFVDDISVL AGVSDPEHGG LGYALLVIKV VTFVIFLTEL
AVSSVVKDAY FASFFFWLDV VTLVSFVPDL VLLFGPRRPC RASCGPDPVL FRVMKVLKLS
HKQTVSASID KLEDHATMYD AAESSRPGGI VLRAMTNKVT ALVLIVYIST AMFQTDPDWS
QHSLSALMTL EAGSAAVGSP AALLPAFLHP YTARVKVVRL FVNGVLQLDG HVPLRRDFRT
TISTPSQASS ILLNISEDRR MDALFSLMSL VVVIVGLGVG NLVICHSANK LVVISEHLMA
IMRLLTSHLK GATSTRRGSL VASDLAPTIL SDLPSVSVFG YNDTQTTLAK TATDGSGMSR
LRPPTATSGH GSGGGGAETI ISALAFWDEA TSHQVGYVEG IEEQLQRYLV DNMRVELEAK
QARRREAELR SLVRLAASRQ ERARAHVERL ITKIDALKHQ VWRYRQHLSR TTRRRLDEED
AEDGSNSALA ELSDVGSVLS VVTLRSGARM ARDAGLTHAS DPSLTEAPEE TQFVSEHDTV
FVERHDGAAV VVRGTVNGLI EQLTTLSGTP STEYLRTFLY TFRRYTHPQH VLERLLIRYC
IAPPQAMRHM PLNAGMQHYD LELGDASMNW ALEVEVPIRN RVQQVLYYWV TNCFVDFVDS
PPLLDLLRRA IDNVFNRTTA PFASRLAAVI ANQLDSGGLS RPPPRRIRLS IAAVPTPRIP
LSIGQSTAVA PSSSEPADSS PSVELSITDI DPLELARQLK LLDHEIYCQV QVWELFDAAW
ESPAREQRAQ NVLALGNVFS ARVFWFRSLI LSDGLSSREQ AHILEYLIEV GTASVEIYSF
NAAVAVLGVL KDHEVGECSS AWRKISSSAA ADYDAFKAVF SRATDFAPYR ERLVHHRTNV
LERAADDGGD PTLPPTAVPY LGFHLEDLFD ADENNPDYTD DSLVNFQKCT LMASLIDFAL
AWRDTAPCFV PVDTIQDFIR DGQLSAVTTP WVPCTAGPLL TPSGAAGLGD PAFDHAVHDS
DDAISATDSD E
//
