ID A0A0L0DK71_THETB Unreviewed; 162 AA.
AC A0A0L0DK71;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Phosphatidylglycerol/phosphatidylinositol transfer protein {ECO:0000313|EMBL:KNC52590.1};
GN ORFNames=AMSG_08453 {ECO:0000313|EMBL:KNC52590.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC52590.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC52590.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC52590.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC and phosphatidylinositol. {ECO:0000256|ARBA:ARBA00002053}.
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the NPC2 family.
CC {ECO:0000256|ARBA:ARBA00006370}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL349474; KNC52590.1; -; Genomic_DNA.
DR RefSeq; XP_013755149.1; XM_013899695.1.
DR AlphaFoldDB; A0A0L0DK71; -.
DR EnsemblProtists; KNC52590; KNC52590; AMSG_08453.
DR GeneID; 25567144; -.
DR eggNOG; KOG4680; Eukaryota.
DR OMA; TFDICNE; -.
DR OrthoDB; 7182at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0015918; P:sterol transport; IEA:InterPro.
DR Gene3D; 2.70.220.10; Ganglioside GM2 activator; 1.
DR InterPro; IPR036846; GM2-AP_sf.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306; NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED; 1.
DR PANTHER; PTHR11306:SF0; PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..162
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005537585"
FT DOMAIN 34..159
FT /note="MD-2-related lipid-recognition"
FT /evidence="ECO:0000259|SMART:SM00737"
SQ SEQUENCE 162 AA; 16988 MW; C044E91B14C67B15 CRC64;
MKLFVVLVLV ALAATAMASV PMCSSDPVPN SQGWCDCGAS TDDAQIESVT ISPSGGTVNK
GSNVTLTVTA SDTKTYPVDT GSTVTVQVKY GIITLLHHTY DLCTLLNDTP YKCPIAPFAS
KTLSISEMIP SEAPSGKYTG KATAVDQKNN EIACIEFAFS VQ
//
