ID A0A0L0DKC8_THETB Unreviewed; 1106 AA.
AC A0A0L0DKC8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=AMSG_07899 {ECO:0000313|EMBL:KNC51818.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC51818.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC51818.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC51818.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; GL349470; KNC51818.1; -; Genomic_DNA.
DR RefSeq; XP_013755684.1; XM_013900230.1.
DR AlphaFoldDB; A0A0L0DKC8; -.
DR STRING; 461836.A0A0L0DKC8; -.
DR EnsemblProtists; KNC51818; KNC51818; AMSG_07899.
DR GeneID; 25566720; -.
DR eggNOG; KOG0973; Eukaryota.
DR OMA; PEMSKNR; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 11..44
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 152..183
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 209..250
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 251..292
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 904..1059
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 56..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..87
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1106 AA; 116393 MW; 72DB0CB51E559C63 CRC64;
MAVDLCKAKW VNHGGNPIFS IDIHPSATRF ATGGSDRNVK IWSMVPFVDA AAKLTGSATS
DSDDESDDSG VYTTSEDDDD DDDDAGYDDD GKSKGSGKKG SSKKAAGKAG KASRMDLLMG
SGATGFGSAA SQGSPPRAAS AVERQHRCLA TLPRHQGAIN AVRWCASGEF LASGADDKVI
IIWAQSDSPT QVFGSAKVNH EGWGFYRALR GHTADVTDLA WSCDDSYLAS CGVDGDILVW
DTTEFELLAT LKGHSEFVKG LAWDPVGKYL ASQSNDRSLK IWSTTEWRQV ASVAAPFEGS
PPHSFFRRCS WSPDGKWLTS AYAYNNTNPV ATVLARDTWE TAVEFVGHSE PVVVARYNPR
LFRIPEHFRA TAAAPPASEG ETQAQAQAPG AGAVADESKG ANSAEGDDED EASEAATPTK
DKKRRKKKSG SSSASPGSPS AGGNDDEYFV CCAIGSQDNS ISIWASFQDR PLLIATAMFE
HSVMDLSWSD DGTVLMACSY DGTVGCFVFD IESEHVLSQP VSEREHQRIL ADEYGEFLGK
TVHLQEYAET VSLQSISAPS MTLTPRTVSA VRAETEALRS GLDAVKGAHG IAGKMQQLAV
SEPVALPPVE QKESITKSGK RRVQPQLLST LPGAAAPAVL APRSTSQTGF ARPSMNPPVV
NTLIPRKRTA TRASLGGAGA SDPPGASMAP AAGGVSRAKR QRTLTMGEVE PAEPVARLVV
SAEDLYLDPP AVTPVKAVSF RVAPAPVLLG AGPSSPSGGD EAIEYALEAR GWKLSGPAEA
GPARGSSLSL SQSGELVWEA YVPGRVNAVA ASELLAVAAT FDDGGLHVFS AANGALLSPA
LVLGLPLVMV RVSADLPRIV ALSASGSLRV WEVVGPLARL GAPLGHGHGG GRAAASMVAR
KTLTVAPLLN SVVAGEASAA EVRVADVRSV GPESDVVVEL SNGYVYLHNA AADAWMRVAD
GSYVGSQYFA SSLGFARASL PSGELAAAQL RLVPRLAHQV APFLAALSLS QQRLVTVGYL
EHQVSAALAM GSSSEFEHWM REYVRRLVRD AAEAKLRNVA INLLSTTRAD LDGRSLLKAL
LPEIAQSPQL QKLTAWVTDA LRSEDE
//
