ID A0A0L0DKD4_THETB Unreviewed; 4815 AA.
AC A0A0L0DKD4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Dynein heavy chain domain-containing protein {ECO:0000313|EMBL:KNC52665.1};
GN ORFNames=AMSG_08535 {ECO:0000313|EMBL:KNC52665.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC52665.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC52665.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC52665.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349474; KNC52665.1; -; Genomic_DNA.
DR RefSeq; XP_013755215.1; XM_013899761.1.
DR STRING; 461836.A0A0L0DKD4; -.
DR EnsemblProtists; KNC52665; KNC52665; AMSG_08535.
DR GeneID; 25567210; -.
DR eggNOG; KOG3595; Eukaryota.
DR OMA; NENTIEW; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 2.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT DOMAIN 1360..1771
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1902..2236
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2527..2646
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2867..2933
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 3003..3261
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3279..3622
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3652..3693
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3761..3932
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 4182..4297
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4332..4469
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4517..4811
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 70..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 903..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2454..2495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2574..2610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3695..3752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4491..4521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3503..3575
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 250..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..393
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2464..2495
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3732..3752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4815 AA; 526622 MW; 6F8FE1622B14C5A4 CRC64;
MNTYEGVDPE RLTPLERTHF LALDRFVEHE SLRATEQLVR QRLGEPAGSV AMPPIGSWQV
GAADLASLNS RPDAQAGADG LALPSSGSSH SPAPLRGVEP RSAAPSLLGH ANSYLPRAEN
YATPGRASPS LVKTINTIGR EARVHRTPHV DAEDVRPYPG SVPAASSLSR LLSAADIDDS
TGVGNVTVVE RHLSFSADGA ELAASADRPI TLDDLDNAVS SSDQPSRARR LGPVRSRRGR
GRASRGSRGS GSRALRSRSL SRSLSRPSSL ARAQSRHAGQ ASLSRASVVR SNTTSLRKIM
AAARKTPTRA QSSMRLQPSP ALLEQGETVR ATSALAMTLS SPVCDASHHA TPSRLSPLPS
GSRMREAHRE SPLPPLPPPL QPLLTPQLAP TPTPNPARAE SSNDDDDDDS VPAGFFPLSF
FDDATFDELN EKLSLPNYAV SGLSKFFDVD GSWSWKPCLV VGYNADKALY QIEWLSNHSL
KWVSRLNLVF DGEDMSLFGA RLQAALVARR EAEAMLRYNV RIDLMPTDGL PELDDAAYAS
IVKRVGRDFP HAATLTDRQR AVAAAAVTAE LVARARAGAS DTGAGPSAAF EPTVAGTLFT
DAFEEAVRYH YKRTINQMEF DATLPYRAIN PAEPLPAPTP PVAIPQLGTL VLPHHDFAGH
FASLASAHFL ARPNLAAALR ASWSFLASVT DKPLLLSFLL KPKSRKPSKA VALASLTDFL
NDQTFYMRNT VRDVRYITIQ SLNNALDAGL SAHANAAPYD VVEPAALVRL VNLMLRDALA
IVLASSIDDY TATFVEYIDE LNRMHAACAE ALVAAAYADA DYEYEYDEEE SDPDESTHPV
ASSSASLAPA DSAPSLAGAA DAAADGASAS SGKSRKKRTK EEDLSALVSS YAENFVTGNA
SPAPDAALAP ASTPASRRPS AVSAKSDVPE DAPTFAATAS KTLPPSPSTT TALAPPKVKK
RRARTLTRAV VAASEPGVPP PAPMFQLFGV PGKYLPRKTP LFTVTLEVSP DSDGLLVYSP
SVEHVREVLH HLVDETVSAI QDLPTVQIDE FRPFEVPPLL APDHESSPGM VQARAALDKA
LDWSGAYMRG YLSRLERFHV LLAQTHTEYV ASFTAREPKP KPADYADEVR KVESLIVDIR
SLIDERVVMG MFEVRVVEVK AELERAAHRL RRALLKALRV DTQEYCQALD ERYAAINVKL
TTQPETPEEL TMLKKFIASL PKEKRKLGKR AAELSARFAL LESFGYEISD AIASAHYHIL
SWPRKLDTTM VETERLMGLV RINMTREIKE KLSNLEARAI DASIAIKSFD FADNLDDAET
LGEQAAALRT TLRDLVKEHA LYNKHERLFE FEPSPLPVLS EALAEFKPIY TLWSNAAAWF
TKQGTWLGQT FVTLSASAME KFILKTYKTN SKVLRQLRGQ HIAGATAATA LKEAIETFRA
HMPIIKKLRH PGIRRRHWAQ LNEKTGLNIS PQADWNLYYF VEQHLENHIE EVTKVADVAI
NEYNLETTLD KMIVGLKRES FEVLPYKGSD TFIIGAPDDL VTLLDDYTVS VATMLSSPFI
GPLEEATRKF SAKLKLVQAT IDKWLLVQRS WMYLNPIFSS DDINRALPRG SMLYDAVDAS
WRRTMNKVSR SPAVLSVCDN EDVLEVLIEC HDLLEQIMEL LQNYLDVKRS VFPRFYFLSN
DELLDILAKS TDPTRVQPYL RKCFENIDSL TMVDGAKSRT GRQLIDITAM NSAEGESIAF
SSAVSTLRDV EHWLLDVQSA MRTALAAQVR DSLADHAAAV REDWVLAWPG QIVLAVNQLV
FTQLVTRCLR DRDLRGLKIL QAKLVEQLNR LTELVCSPLT RLQQLTLGSL FVMDVHNRDT
VRELIAHKVV VESDFRWQAQ MRFYMEDDGE IEVRMVLATL AYGYEYLGNT SRLVITPLTD
RCYRTLMSAQ HLHLGGAPAG PAGTGKTETC KDLAKAVAKQ CVVFNCSEAL DYLQMGKFFK
GLASAGAWAC FDEFNRIEIE VLSVIASQIL AIQRGVAAGS KQLMFEGTLL DLDPTCTVFI
TMNPGYAGRT ELPNNLKALF RPVAMMKADY AFIGEILLYS EGFKSAPSLS RKMVNCFKLA
AEQLSSQDHY DFGMRTIKAV LSTAGGLMRA SRASLGRAMN DDDEALILYR ALSDCNVPKL
VADDIPLFTG ILSDLFPTAS PPVPDYGNLD DAILETLAAA NLQPAPAFIH KITQYYETLQ
VRHGVMLVGT AGTGKSAARS VLRDALTATG EPVEDHVINP KSITMGQLYG EVNEVTMEWS
DGILSHIVRG IVERLAEPPP ASAPNGAHPL QWIVFDGPVD SLWIESMNTV LDDNKLLCLP
NSERIKIPPR VSFVFEVRDL SQASPATVSR CGMVYVNENT IEWDHWAASW RARLVPHVAE
AFGSIIDRLM TSLVAPALSL VLRTELSLKT CTAGLMRSLL ILLDVLIPLV SPPESRVASE
SDDSSGSDDD DDADDDDDDF DIDGDGSDDD AADGGDELDE AALAAASLAS ADEAKRAFLE
PIGTAYSDVE LQSVFECVFA WAVAWSIGTI LESTDDRAAF DAIVREALSR KKKAPAPALD
PRESEMSGSN DGAGAGPVEG AETPAPPAVK TGPKLSKLMY PLPQEGTIFD YEFKLSVSEV
GWRAWSTKLN GFELDAAIPL SQVFVPTVES VSLGFVAELL IRSHQRILLA GTSGAGKTYG
LREVLLRKLD SRFVPTFVGF SATVHAGDVQ ALLASKVDRR RKGVFGPMPG KSLVVFVDDL
NMPTPEKYGA RPPIQLLRQV CDQGGWYDSE SLDKQFVELV DVQLAGALTL GSGKAPVSQR
LLRHFNVLYS PEYERESLEY IFSVILKTHL SKFLSDIRSL SSSVISATFD VYAAVIEHFK
PTPSKPHYVF NMRNLFKVFR GMLRASPEKM VHAAEWLLLW RHECTREFGD RLFGADAAVF
TGLVDTIGSS AFSRPVQAES EPLLFARFAH DDGAYSRVRD GQGLVERVEA AKTEYNSMHS
AQLDVVLFQN ALEHVVRLVR AIDQERGHAL LLGTPGGSGR KSLTRLAAAL CDYDLFTIEL
KSKYSRNEWH EDLRTVLKLA GAEGEPVVFL FDEAQAIDEA FLEDLDNILH NGDVPNLFGS
DDMEIISRSV TAALQAKGGA SATVGLTREA VYQEFVSRVG PTSILSSRLR DFPSLVTACT
LDWYGPWPIE ALHAVGTATL EHTPFRVGEG ERVPQAEAFG LLSSVVEVAV GMHSSMVQLA
EEYTLSQLYV TPSRFVELLK FARDSYMAAR QSLQNEVGRF RSGLAQLGKV EALVATLQED
LSTKLPVLSK TRTEVEALIE TLTVNQAEAK KTKAAVESEE VQAQAEQKVC EQMVERTEAE
LSEALPELEA AQRALQELRP SDIVEIRSMQ HPPPGMTIAI EAVCILLGHR PKMVAGPRPG
SKVPDYWPVA RSLMADGFVK KLLGFEPESI TAATVARLEP YITNPKFATA KMAKISVPCA
KMTDWVTSMY KFYFVNERVK PLRAEAEGAK VSLDETLARL EAARATLREV EERIDELTAE
YVAADERKSV LEAEVEECKL KIARAEELND GLGDEKVRWR ERVVELSAEF GSQLGDVLLA
AGVVVYLGEV GTQARREMVA KWRALVEGKN MMVSADWSVV KVFGDELQLL GWQILGLPRG
GYSAENAVIA SSTSKWPLLV DPQGQANSWI RRAAQAGPEP VGGTAPAPAS PSHGDDVSGS
NDEGESDGEP SSADLAGTSG TPGESAGTGG SGASLGSGLG LVVVKPSAPD LVRVVEAAIV
SGKTLLLEDV GEELPAVLNE LVRRAVVVKD GMRVVRLADK MVPYTESFQM YMTSRRSGGF
PPQLATQVTL VNFAVTRAGL EEQLLAVVVA KENQAIEAKK TTIIRENAAD MAALSALEDK
ILELLSSASG DILEDDVLIQ TLKNSKRTSI DIAKRLKEAA VTEKDIDAAR SQFKPVALRG
TELYFTSACL EKLDPMYQFS LRWFLNVYSG TIDATAHVAG QDMNGRLAAL NTALSSAFYV
NVCRSLFEEH KLLFSLHLAV TLNREQLDDD ELNFVQRGAG LVIAADQEKS VDIDEWLNDA
SWVQVCELTK LPAFAGLAES INGADADGWR GVYEAAVPEA AMWPGSWSSG LTTLQRMCIL
RCLRPDRMRT MLASLVEELL GREFVEPPPF SLASAFEDSR VNVPLIFILS PGVDPLKELY
KFGASRGMSS ERIVVISLGQ GQEARAVEQI EKGIDFGHWV VLQNCHLLLS WMPALEKIVA
ELPDENGRVH SKFRLWLTSK PSPRFPVSIL QIGVKITNEP PRGVRANMRR SYVSFSEDEH
FASDARRDPV AHKLTWMLTF FHALVQERRK FGPLGWNKAY EFSESDLLAS KEQLYLLLEA
NQDVPFYALN YLTGEIMYGG RITDDWDRRL CATLLGGLFS KKVLSSGWRY TSTGEYRAPG
AGPLSEYLDH IDALPEVDSA EVFGLHSNAE LSLAVVEGLK LCEGLVSLGS GGSGSAPAAA
AATDEAGESK ADENEADTEE SASFEAVVAE RVKELLALVP TGLDPRAVRA KYPLKHEDSM
ATVLYHDCTR YNSLLGVVEG SLTDLLAALQ GRIVMSAALD AVAQRVFDGL VPGAWGDAGY
LSEKALGPWM ADLRSRLEFL QRWFEDGPPV VYGLGKFFYP QAFLTGVLQN YARKYSVAID
GVVFRAHVMD EGAVLAEPPA DGAYVSGFFI EGARWDSVRG VLVEQRDKEL ISPMPPIWLE
PVVASGDGDG DEADEDPSAK NALYDCPVYK TLARYGQVST AGQSNNFVLA VGLPTDREPG
HWVRRSVAMF LELRE
//
