ID A0A0L0DM33_THETB Unreviewed; 1136 AA.
AC A0A0L0DM33;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=AMSG_12204 {ECO:0000313|EMBL:KNC53325.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC53325.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC53325.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC53325.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
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DR EMBL; GL349480; KNC53325.1; -; Genomic_DNA.
DR RefSeq; XP_013754603.1; XM_013899149.1.
DR AlphaFoldDB; A0A0L0DM33; -.
DR STRING; 461836.A0A0L0DM33; -.
DR EnsemblProtists; KNC53325; KNC53325; AMSG_12204.
DR GeneID; 25570119; -.
DR eggNOG; KOG0924; Eukaryota.
DR OMA; VDVMFHR; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT DOMAIN 399..553
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 575..750
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 64..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1085
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1136 AA; 123164 MW; 3A925405105914FF CRC64;
MGDERVAETF ALWMGNELNM PTTDARVGAA ALAAARAASS ADDLVARLSE FGKVSTETAQ
EMLDEIGQGS RRQPAGMGLK RRRSPEGGAA GERKRAKSGV APADARLLSF GNEQRGSRGD
ASRIRPRSAA SSAPAPAASM EDVEAEVLER EGDREWYNDD GGVYDPDADP WVVAAEAAPE
ARMEAGAHLA KQQVGSLTAK QAAYTSALDK WERDRMASSG VKGVRKVRTL LAGDDDESHL
RVHMLVTLSV PPFLDGRIKY TKQSSMVSCV KDPTSDMAVI ARKGSAALRE FRARAERLKA
EGQYWKLAGT QLGKLMRVSA AEENAQDDAR LSAIQRQLRA QKRAEESALE AAAQSGDTRA
ASQYGAGKTS TAGERATASE SLAATRKSLP IYTVRDKLLQ VIRENRVVVI IGETGSGKTL
SFRSGLKIGC TQPRRVAAMS VAKRVAEEVG VPLGAEVGYS IRFEDMTSPT TRIKYMTDGM
LLRESLRDSA LDGYSVLVLD EAHERSLNTD VLFGLLHRVL AQRLDLKVIV TSATMDADKF
SAFFGGVPIF SIPGRTYPVD VLFSKTVQED YVDAAVNQIL RIHLSQPVGD ILVFMTGQAE
VEAVCQLAME KLDELDTPAP LLMLPIYSQL PADMQSRVFE AAPPGFRKCV VATNIAETSL
TVDGIVYVVD CGYCKTKAFN PRIGMDALLV TPISQANANQ RSGRAGRTGP GTAYRLYTRS
QYELEMLSTG IPEIQRTNLG NVVLLLKSLG VDELMQFNFM DPPPEDTILS SMYQLWVLGA
LDNVGELTAT GRLMVEFPLD PQLSKMLVLS AELGCSAEVV IITAMLSVPN VFARPKSRET
EANAAREKFN VAESDHLTLL HVYQQWTANK CSSAWCTKHF VQMKALIRVR EVRAQLLDIM
KSQRLPVISC GSDWDVVRKT IAGAMFEKAA RIKGIDEYVN LLTAMPCHLH PSSALIGLGY
SADYVVYHEL VLTSKEYMRV VTAVDPHWLA EFGSAFYAVK DGIGSRASRA RELASRKADM
EEEMRLSRAL SRAPSSAVSA PPRSRAASVA IGVVSQRRHS APTPTGGIAP PPPPSSAPPP
PSSAAPLLET GVKGKDKAKK KKKKKKKDKL PSTADLIAAV HMQSAAAAKK RKRGRL
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