ID A0A0L0DM72_THETB Unreviewed; 767 AA.
AC A0A0L0DM72;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=NhaC Na:H antiporter family protein {ECO:0000313|EMBL:KNC52488.1};
GN ORFNames=AMSG_08045 {ECO:0000313|EMBL:KNC52488.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC52488.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC52488.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC52488.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL349473; KNC52488.1; -; Genomic_DNA.
DR RefSeq; XP_013755285.1; XM_013899831.1.
DR AlphaFoldDB; A0A0L0DM72; -.
DR STRING; 461836.A0A0L0DM72; -.
DR EnsemblProtists; KNC52488; KNC52488; AMSG_08045.
DR GeneID; 25566826; -.
DR eggNOG; ENOG502QWQB; Eukaryota.
DR OMA; NTWNMSI; -.
DR OrthoDB; 36370at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR43478; NA+/H+ ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43478:SF1; NA_H_ANTIPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03553; Na_H_antiporter; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..767
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005537643"
FT TRANSMEM 137..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 282..358
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
FT DOMAIN 493..683
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
FT REGION 415..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 81593 MW; D311D110FDC60B00 CRC64;
MACLLLASAA WATKTVSCDQ GSGMLLPEVM LTHIRVKPQL VLTPYYNNSL WASNLTISQR
IHTPSHGWRP WVVGHVATEL ANGTRVLDHD VPSFVVNSAG MVRLEVIVRA AGSTDSLCGF
TTIRRVLPGW VSVLPPMLTT VVAIAFRQVL LALFSGVWLA AFLLNRLDPL EGLLRSADTY
WVQAIEGSGH PGVILFTFFL GGCIGIVSKM GGTLGLAKVV TKLTKSSFSA KVCTLAMGLV
IFFDDYSSIL IVGSTMKPIL SRLAVSPAKF AFLIHVMGAC LASFAPVSSW VGVEVGYIQT
QYEQLGLDGD AFVIFLQTIP YRFFPVLMIV FVWILTLMRR DFGPMLALEE DALAEQEAVS
RRRTDSSMSM ASSRRGMSIN SAKYALRSGE VGGGLGYSTT GDPILVRGLS SNETSMRVGD
EPRLLSGASS DSGSGDGAGA GDGGALAPKP GAPQRWFNAA IPFGIIIVVT FVGMYLDGYY
TLRGEKNPPP RTLVNIFSNA NSIDALLWAS LLGTMAALFL ALLQCILTLS EAMEAWVEGV
KDILEAIIIL LLAWALGGVI FDLQTAAFLS EICNGIPVGI LPLIITLTAF LMSFATGSAF
GTMGILFPLV VPLAYTLSTK STAHAASNVV LQSVSSVLSG AVFGNVIAPI ADNSVLACMV
SGADIPLHIS SMALYVGIVS VVSLLGGTIP CGLGWYPSWV GLLICTAILI GIVFVFGKVP
SVDRGMARIS ERTALLSGAV AESGGVDFYE TDVPQKRRIF CPCWRSK
//
