ID A0A0L0DMC7_THETB Unreviewed; 1054 AA.
AC A0A0L0DMC7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=AGC/AKT protein kinase {ECO:0000313|EMBL:KNC53425.1};
GN ORFNames=AMSG_08933 {ECO:0000313|EMBL:KNC53425.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC53425.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC53425.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC53425.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349481; KNC53425.1; -; Genomic_DNA.
DR RefSeq; XP_013754462.1; XM_013899008.1.
DR AlphaFoldDB; A0A0L0DMC7; -.
DR STRING; 461836.A0A0L0DMC7; -.
DR EnsemblProtists; KNC53425; KNC53425; AMSG_08933.
DR GeneID; 25567509; -.
DR eggNOG; KOG0598; Eukaryota.
DR OMA; YAFIEER; -.
DR OrthoDB; 10768at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17043; RA; 1.
DR CDD; cd05123; STKc_AGC; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045270; STKc_AGC.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR PANTHER; PTHR24351:SF243; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00433; Pkinase_C; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KNC53425.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..198
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 619..705
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 727..983
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 984..1054
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT BINDING 765
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1054 AA; 111442 MW; 97C4DEF3CF06FAA1 CRC64;
MTGTPFAVFG VPLAQSLSNA GQAPNEVPAV VDAAITALLA LPSLPDGFSI SLSNDYQSVQ
NVRMQADDCE SPELSGLSAS ELVDVVRMFV SALPAALIPA DTAKAMILLT TTAPSTGRAD
KYRYLLGTLA PAERALLTRI LEAIRRMVKA PGVSMANAVA AFGPAFIRDP ESSTLSKLRL
DALQPLVAVL AGEYASLFST PVEGSVEYVS FGVTRATLVP FSSSFLAADA SDVVFIMRQA
GNAPLWYGES SSGAGHFPPA AVQVVGFLPP LHGSAAAAPR PKAVTSNATA LRGAPLTISI
GGKTVYNGAI QHSSAFKEAM ASASPSIAIT LVTGETTSLL AVGDNAVLEH KMRLVVEDSL
LHAVTAMDPA MPAGAALSIA VTTEAGPSTV LMYVPKGSKL VHVNGALATA FGVPAGLCET
TVGEVSSTTA GESDALQLEA DVPDAQFAFA VTGRAAAVEP AGASTATAAA GGSGTGAGAS
AAATGAGASA ANSTGASSSG ASAGGDGGDD GGEATYGGAP IILQIWFREG SYKKLKSTSE
TPCFEVVAKI ASNRAAKAEA YTLALVAAKS DTPFKYLGDE DLPSAVLKSK PGSRLMFVRK
LQRSGDAAVN VRELNRKSSV SIVQVFYEDH YSSFRCSPAT TAAELAEQVM RKPVFAGKDL
SAYALYEKVG ELQRQLEPSE LPSDLFTKYQ SEGVVVQFVL RHKTLELGEY AFIEERTRKE
KVKLEDFDLL KVIGRGGYGK VCQVQKKDTG GIYAMKIISK ASIVKEKDLL HTKEEQRILA
SIKHPFLLHL QYSFQTPEKL YLVMDYINGG ELFFHLSNEG FFPEEQAKFY TAELVLALDH
LHSHNILYRD LKPENVLLDA EGHVRLCDFG LCKATASTTG TLCGTAEYLA PEMLKGEGYG
PEVDWWEVGV LMYEMRTGAP PFVAEEGESQ VDLFRKVLYS NPPVDPAVFS DNAASLLLGL
MEKDPSQRLG SNSVEDIKSH PFFACYDWDA LYNRQIEPPF KPNVADASST ANVDEEFLNM
SVADTLVEPS ELSSVVQGSA FDGFSYVADS AFNN
//
