ID A0A0L0DSR6_THETB Unreviewed; 816 AA.
AC A0A0L0DSR6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Uracil-DNA glycosylase {ECO:0000313|EMBL:KNC55394.1};
GN ORFNames=AMSG_11053 {ECO:0000313|EMBL:KNC55394.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC55394.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC55394.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC55394.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC UNG family. {ECO:0000256|ARBA:ARBA00008184}.
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DR EMBL; GL349500; KNC55394.1; -; Genomic_DNA.
DR RefSeq; XP_013753025.1; XM_013897571.1.
DR AlphaFoldDB; A0A0L0DSR6; -.
DR STRING; 461836.A0A0L0DSR6; -.
DR EnsemblProtists; KNC55394; KNC55394; AMSG_11053.
DR GeneID; 25569121; -.
DR eggNOG; KOG2994; Eukaryota.
DR OrthoDB; 11658at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR CDD; cd10027; UDG-F1-like; 1.
DR Gene3D; 1.10.8.50; -; 1.
DR Gene3D; 3.20.190.10; MutM-like, N-terminal; 1.
DR Gene3D; 3.40.470.10; Uracil-DNA glycosylase-like domain; 2.
DR InterPro; IPR012319; FPG_cat.
DR InterPro; IPR035937; MutM-like_N-ter.
DR InterPro; IPR010979; Ribosomal_uS13-like_H2TH.
DR InterPro; IPR002043; UDG_fam1.
DR InterPro; IPR018085; Ura-DNA_Glyclase_AS.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR PANTHER; PTHR11264; URACIL-DNA GLYCOSYLASE; 1.
DR PANTHER; PTHR11264:SF0; URACIL-DNA GLYCOSYLASE; 1.
DR Pfam; PF03167; UDG; 1.
DR SMART; SM00898; Fapy_DNA_glyco; 1.
DR SMART; SM00986; UDG; 1.
DR SMART; SM00987; UreE_C; 1.
DR SUPFAM; SSF46946; S13-like H2TH domain; 1.
DR SUPFAM; SSF52141; Uracil-DNA glycosylase-like; 1.
DR PROSITE; PS51068; FPG_CAT; 1.
DR PROSITE; PS00130; U_DNA_GLYCOSYLASE; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT DOMAIN 2..161
FT /note="Formamidopyrimidine-DNA glycosylase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51068"
FT REGION 664..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 400
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10072"
SQ SEQUENCE 816 AA; 85272 MW; 6F40E3C6DC480431 CRC64;
MPELPEIARY ARNISALPAT TRFTRVVSVA GGKVPPANLP FTAFSLSARA RGKELRLELR
PATAASTATG SSSHASACAL GSFALAPPVA RQDQAPVIWR CNHGLVGKWL VVRHGPADRA
GAGLGAHDGG GGGEAGAPQG TRLMILGESA SVYYVDTLNM GRIVEDGWSS GRSPCPYGEA
EAWEAHVAAA LAKTKRPAVF AKPLADALLD QKYFNGVGNY LRAELMYRLQ LDPHIPLVDA
LSGTGALAVL GRELRAIVAE VLDSIPPLDK YGSDEDKARF EAWLQIYNKG EFYKDGKGRK
VWWAPAVQTR TSLSDAPGAV SGSPPPPGQP LRLSFIPPME SSWAEALREV LQSGTIRELE
SFLASEVSAG KQVFPPREEV FSAFYATPLH AVRVVILGQD PYHDDGQAHG MSFSVKPGIN
VPPSLANIYR ELADDIDGFV AQTTGRGWEA LTHAAIAAVA ARLPHAVFLA WGSFAQKALR
KVDTARHAVI ATPHPSPLSA SRGFFGSRCF SAANAALVGF GLSPVDWRLP TVPTLTVPAA
ALPAPAASVD NELAAALAAL TIDDAAYEPV YTFERAIGLD MLLDAAIVVE AEADAKSDAA
PAAQAATGAG ARASVPSLKF ASTSTIPSAF ATKTSLAYSS FAVTSPTFKS AAERADELRR
KYAAMAKART SPRISPRASS PSALSPQLAP APGPVVGTGF VVKHQPRSLS PVGGPASTSP
RALSPQASTQ LISPASASIS PLAMSTGRPA FAAPGASTIA SASNPIAEYR AASEAKFSQL
RSKYVSSDVQ KRVRAVSPPG RTGAGPRSRS SSPQSR
//
