ID A0A0L0DUF7_THETB Unreviewed; 409 AA.
AC A0A0L0DUF7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cobalamin synthesis protein {ECO:0000313|EMBL:KNC55078.1};
GN ORFNames=AMSG_10677 {ECO:0000313|EMBL:KNC55078.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC55078.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC55078.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC55078.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; GL349495; KNC55078.1; -; Genomic_DNA.
DR RefSeq; XP_013753262.1; XM_013897808.1.
DR AlphaFoldDB; A0A0L0DUF7; -.
DR STRING; 461836.A0A0L0DUF7; -.
DR EnsemblProtists; KNC55078; KNC55078; AMSG_10677.
DR GeneID; 25568843; -.
DR eggNOG; KOG2743; Eukaryota.
DR OMA; DAAWEMV; -.
DR OrthoDB; 50694at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43603; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR PANTHER; PTHR43603:SF1; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408}.
FT DOMAIN 264..373
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
SQ SEQUENCE 409 AA; 44759 MW; BA14C7D46F4D86B0 CRC64;
MSRKHQNDSR IPVTVLSGFL GAGKTTTLNK LLSNKAGAKL AVIVNDMSEV NVDAMLVKQS
KDEMIELSNG CICCTLHGDL LDSIAAVVKE RSVDGLDGIV IESTGISEPL PVAQTLSLDP
AELGDDSLTS VADLVYVDTM VTVVDGPALL ARLAAGEDLI SLSMAENDDD DRTVADLLID
QIEFADVILV NKADVATKDE IDTVVALVRR LNRNARVITT IHGLVEPKAI FGTRRFNLDV
AETAPGWLQE LLGVHTPETE EYGISSFVYR SKTPFSTQRM FDLADADDTP FGQTVIRAKG
FLCSLLTRWL SALRHGLTWL IRLRSGTWPE DPIMRKEIKK NWDPRWGDRA TELVCIGVNM
DKAVITEALN ACLLTPDEMA LGPEAWADMA DPLEEWDDAT EAHGDNHQH
//
