ID A0A0L0DUL2_THETB Unreviewed; 838 AA.
AC A0A0L0DUL2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMSG_02036 {ECO:0000313|EMBL:KNC56024.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC56024.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC56024.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC56024.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586}.
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DR EMBL; GL349440; KNC56024.1; -; Genomic_DNA.
DR RefSeq; XP_013761068.1; XM_013905614.1.
DR AlphaFoldDB; A0A0L0DUL2; -.
DR STRING; 461836.A0A0L0DUL2; -.
DR EnsemblProtists; KNC56024; KNC56024; AMSG_02036.
DR GeneID; 25561747; -.
DR eggNOG; KOG3667; Eukaryota.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09919; SH2_STAT_family; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF43; SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999}.
FT DOMAIN 24..124
FT /note="STAT transcription factor protein interaction"
FT /evidence="ECO:0000259|Pfam:PF02865"
FT DOMAIN 174..321
FT /note="STAT transcription factor all-alpha"
FT /evidence="ECO:0000259|Pfam:PF01017"
FT DOMAIN 505..574
FT /note="Signal transducer and activator of transcription
FT linker"
FT /evidence="ECO:0000259|Pfam:PF21354"
FT REGION 125..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 90082 MW; 1CC0FD579C012C23 CRC64;
MDGETLWSYI QDNPEVVAVY AESNPHFPKE VRACCAGWIE SRDWSTPVRA EQAPALARGL
FDALTEVLQH LETVAASVPH ARFKLNRLTQ IGRTLREEYA GNDARLLEAL RVCMMAEAAV
LEGAEGEGGV GGGSAGVGAS SRAPQAMEDG GQSPREGEDV VSGRAGPLLR QYNGLAHEAR
GSEDELRSVQ ELQEEFRVQY LQNEDRIAAL AQGSGPNNPQ ARQQLHALYQ SLAQQSEQLI
GMRRSLRSAL AGEANMLRTL QATLGEMLGE WREKQFRKAV PEKILAAELR ELRQLLMRQA
AALFSLRERL EVLRFLRQQL PPAASADDDG EVSVPEAETL AAAADAMIEN LVLGSWVVVE
QPPSVVRRRV RTRVSIELLI GASHVVSLPM VSVQLLDAVT GEPASAQLLN ATKRAEATND
GRCVAVFSSL CIADIRHASL TKDKLSAECM YRLAVSCEAG LAHGTYSLIA VSNPITLTVS
RRQAALAAAT MFWHEAFADS FEAITAPETV FWSALAGALE ASFAASGREL GADVLAYFRS
KVVSSVPGDS SDIVSFEQFA KADMGKGFSF WAWLFAAREV LESSPHMRAL WADSLVAGFV
PKSGVGGMLS AYPSGSFLLR FADSLLGALS ISYVWDDSRG RQVVHLQPWT LTEFETISLA
DRIRQTEQLT LLYPTFQHRD EAFGAYYSPD EAVQAVDGYV TTGLKMTVEG GSESRQGGGE
SAFSFPLDLG PVSPLGEASN PFYTGMEPAE PAAGYSGMLL SPSLGAPAFG GEGPSSEGGG
RLPELSFNMG LEPLRFDEAP SLGSPPLQGS ASAEGGLFGF GGSRQRSLGG DELRDMLQ
//
