ID A0A0L0DX60_THETB Unreviewed; 790 AA.
AC A0A0L0DX60;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KNC56108.1};
GN ORFNames=AMSG_02123 {ECO:0000313|EMBL:KNC56108.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC56108.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC56108.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC56108.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL349440; KNC56108.1; -; Genomic_DNA.
DR RefSeq; XP_013761150.1; XM_013905696.1.
DR AlphaFoldDB; A0A0L0DX60; -.
DR STRING; 461836.A0A0L0DX60; -.
DR EnsemblProtists; KNC56108; KNC56108; AMSG_02123.
DR GeneID; 25561829; -.
DR eggNOG; KOG1703; Eukaryota.
DR eggNOG; KOG4424; Eukaryota.
DR OrthoDB; 370973at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08368; LIM; 2.
DR CDD; cd00821; PH; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24210; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24210:SF12; LIM DOMAIN-CONTAINING PROTEIN DDB_G0271356; 1.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00132; LIM; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..790
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005537516"
FT DOMAIN 62..119
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 120..180
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 434..615
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 653..753
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 365..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 85069 MW; 16554FC9632AEA53 CRC64;
MTRMLVPMVL VAGAVEAFGT RWHAEHMACK ECGLDLVVAE PFLDKTSGYV YCADHFNALH
HLTCQGCGDV IVGAHLYELD RHWHQACFVC TVCACAFTSS YHVHRNKPYC PEHYYTRLGY
ICSACTKPIT DGAHIRACDS MWHASCFVCS ACSAVLDHGY FRGPDSRPLC PECSQPSALR
NMALAGRSST LPTSARPAPP HTGVGRRSWS QLTAPVVNEH NASPEDHNEL LRHRLRVFVN
HLGARHYGEL RAAVLAVVKQ VHMLAAAVTA LQGFDSQDLV NAAVAFASKA RILFNGRNGM
TTTALDSVVQ SIVAAARNLT DAAARTVALH TSLSQLGSLL DVYPRPPSVH DALVGTEAEG
ASAADDALSI RTSSASESTE AVPSGDFDRD GPQVHGGKPG ETDQFVARVL LASDAEDGSS
GAANLVSLTP NDVRRLELVR ELIASEEKHV AQLATVTYDY LMPLRFLGAN TLAVDKREII
FCNVESLFAF HSEFLEALRA NSAESPTAAG LDSVLAGAMD DITSLYRTYG MNSALALGEL
TKVREAPGAH RAFLDFLSEA AARTEATVAY KSKLEQLLMV PLKRLAALTL LVTQLAAVAE
PGSLLPDHAA RLDALASEVH AAQTRMINWQ RVVMVKAAVR DCPFDISGNS ERVVRKEGPL
ERCGGSSGTS KKVETFYVFL FSDVMVWTKP SKKEGFFVFK GMATLVDIEA MYQDSGSSSG
FSIELNDGRT IHWLAASFNE MQAWLLALGP TLAEFQDELI GLVHASPAAD TAHAATPASA
SGPDPTSHYS
//
