ID   A0A0L0FFD4_9EUKA        Unreviewed;       622 AA.
AC   A0A0L0FFD4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Cystathionine beta-synthase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SARC_12713 {ECO:0000313|EMBL:KNC74748.1};
OS   Sphaeroforma arctica JP610.
OC   Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX   NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC74748.1, ECO:0000313|Proteomes:UP000054560};
RN   [1] {ECO:0000313|EMBL:KNC74748.1, ECO:0000313|Proteomes:UP000054560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP610 {ECO:0000313|EMBL:KNC74748.1,
RC   ECO:0000313|Proteomes:UP000054560};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA   Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA   Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA   King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Sphaeroforma arctica JP610.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR   EMBL; KQ244120; KNC74748.1; -; Genomic_DNA.
DR   RefSeq; XP_014148650.1; XM_014293175.1.
DR   AlphaFoldDB; A0A0L0FFD4; -.
DR   STRING; 667725.A0A0L0FFD4; -.
DR   EnsemblProtists; KNC74748; KNC74748; SARC_12713.
DR   GeneID; 25913217; -.
DR   eggNOG; ENOG502SIPJ; Eukaryota.
DR   OrthoDB; 47438at2759; -.
DR   Proteomes; UP000054560; Unassembled WGS sequence.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR11808:SF15; CYSTATHIONINE GAMMA-LYASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   4: Predicted;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054560}.
SQ   SEQUENCE   622 AA;  66936 MW;  0178C5AC0E77E9FB CRC64;
     MNYSNKMRFL NRDLTSNHFK AVIPALLSNL PKDWYGTTFK NHDLLGRGKF GTNLSNLLLT
     KDHDAITSED LGALGNAEDY LRVSSNISTI LEAALAVERD LDVTEVFSFG STTMPVIAVL
     LTAAKPVHMY VGENGDAPFT STQMNTLKLL GCDLTVHQSL PSERSDTRVT ITNLQDSSLT
     EKVDGVIAPN VLYIINPETI LSNSILTIRK RMSTPVTTPV AIEMLRQYAG LPVQDSPKPT
     GEELAAFYAH LQTMSGTPAN ASANPACFTA GLPSIASLWV TLVGQGGADV LMASTAYGGS
     SQLTDLLCDK TEVMTKHTYD ITGSNDISAA IQGALTKLAG NAQNLHPRTV LFVEIPTNPD
     MKIPDMKALA EMLTKYREDT QKDVLLLMDT TFAPGSRVME LMSAHAPNLT MLTFISMSKS
     VSRGLTTAGA LVCGSSDASV ALLGKVKDTA QMLDVSAKRD QMRFLVGNHE GVEARCQKAY
     TNAVLAGNAL KEVVAEVRDG YEMGLNFVTE KQAALGFHTS TFSFNLPVVK NGTASENAAL
     AQKFTDLLQQ HDAVFKPCVS FGQDNGLVYA TVPATSTQGA IKEEDKAKQA VGGVQLCRLS
     FPPTIDMEKV CGIIRDAVRN VY
//